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Search results 2901 to 3000 out of 202262 for *

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Category: OntologyTerm
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Type Details Score
Ontology Term
PANTHER:PTHR24067:SF22 | UBIQUITIN-CONJUGATING ENZYME E2 O
 
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Ontology Term
Pfam:PF11779 | Small subunit of serine palmitoyltransferase-like
Description: Serine palmitoyltransferase (SPT) catalyzes the first committed step in sphingolipid biosynthesis. In mammals, two small subunits of serine palmitoyltransferase, ssSPTa and ssSPTb, substantially enhance the activity of SPT, conferring full enzyme activity upon it [1]. The 2 ssSPT isoforms share a conserved hydrophobic central domain, which is predicted to reside in the membrane.
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Ontology Term
Pfam:PF12041 | Transcriptional regulator DELLA protein N terminal
Description: Gibberellins are plant hormones which have great impact on growth signalling. DELLA proteins are transcriptional regulators of growth related proteins which are downregulated when gibberellins bind to their receptor GID1. GID1 forms a complex with DELLA proteins and signals them towards 26S proteasome. The N terminal of DELLA proteins contains conserved DELLA and VHYNP motifs which are important for GID1 binding and proteolysis of the DELLA proteins. [1]
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Ontology Term
PANTHER:PTHR11932:SF27 | CULLIN-4, ISOFORM A
 
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Ontology Term
PANTHER:PTHR11986:SF18 | ORNITHINE AMINOTRANSFERASE, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF03634 | TCP family transcription factor
Description: This is a family of TCP plant transcription factors. TCP proteins were named after the first characterised members (TB1, CYC and PCFs) and they are involved in multiple developmental control pathways [1][2][3]. This region contains a DNA binding basic-Helix-Loop-Helix (bHLP) structure [1][3].
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Ontology Term
PANTHER:PTHR12413 | DOLICHYL GLYCOSYLTRANSFERASE
 
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Ontology Term
Pfam:PF03155 | ALG6, ALG8 glycosyltransferase family
Description: N-linked (asparagine-linked) glycosylation of proteins is mediated by a highly conserved pathway in eukaryotes, in which a lipid (dolichol phosphate)-linked oligosaccharide is assembled at the endoplasmic reticulum membrane prior to the transfer of the oligosaccharide moiety to the target asparagine residues. This oligosaccharide is composed of Glc(3)Man(9)GlcNAc(2). The addition of the three glucose residues is the final series of steps in the synthesis of the oligosaccharide precursor. Alg6 transfers the first glucose residue, and Alg8 transfers the second one [1]. In the human alg6 gene, a C->T transition, which causes Ala333 to be replaced with Val, has been identified as the cause of a congenital disorder of glycosylation, designated as type Ic OMIM:603147 [2].
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Ontology Term
PANTHER:PTHR24343:SF66 | CBL-INTERACTING SERINE/THREONINE-PROTEIN KINASE 8
 
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Ontology Term
PANTHER:PTHR15835 | NUCLEAR-INTERACTING PARTNER OF ALK
 
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Ontology Term
Pfam:PF07967 | C3HC zinc finger-like
Description: This zinc-finger like domain is distributed throughout the eukaryotic kingdom in NIPA (Nuclear interacting partner of ALK) proteins. NIPA is implicate to perform some sort of antiapoptotic role in nucleophosmin-anaplastic lymphoma kinase (ALK) mediated signaling events [1]. The domain is often repeated, with the second domain usually containing a large insert (approximately 90 residues) after the first three cysteine residues. The Schizosaccharomyces pombe the protein containing this domain (Swiss:O94506) is involved in mRNA export from the nucleus [2].
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Ontology Term
PANTHER:PTHR12553:SF7 | METALLO-BETA-LACTAMASE DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR10965:SF0 | 60S RIBOSOMAL PROTEIN L38
 
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Ontology Term
Pfam:PF00337 | Galactoside-binding lectin
Description: This family contains galactoside binding lectins. The family also includes enzymes such as human eosinophil lysophospholipase (Swiss:Q05315, EC:3.1.1.5).
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Ontology Term
PANTHER:PTHR22536 | LUNG CANCER METASTASIS-RELATED LCMR1 PROTEIN
 
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Ontology Term
PANTHER:PTHR22536:SF1 | MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 19
 
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Ontology Term
PANTHER:PTHR15315 | RING FINGER PROTEIN 41, 151
 
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Ontology Term
PANTHER:PTHR31623 | F21J9.9
 
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Ontology Term
Pfam:PF08492 | SRP72 RNA-binding domain
Description: This region has been identified as the binding site of the SRP72 protein to SRP RNA [1].
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Ontology Term
PANTHER:PTHR24312 | FAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR24312:SF0 | CARBONYL REDUCTASE FAMILY MEMBER 4
 
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Ontology Term
PANTHER:PTHR13710 | DNA HELICASE RECQ FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR13710:SF1 | ATP-DEPENDENT DNA HELICASE Q4
 
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Ontology Term
PANTHER:PTHR31446 | ACID PHOSPHATASE/VANADIUM-DEPENDENT HALOPEROXIDASE-RELATED PROTEIN
 
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Ontology Term
Pfam:PF02681 | Divergent PAP2 family
Description: This family is related to the Pfam:PF01569 family (personal obs: C Yeats).
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Ontology Term
PANTHER:PTHR24056:SF107 | CYCLIN-DEPENDENT KINASE 11A-RELATED
 
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Ontology Term
PANTHER:PTHR31963 | RAS GUANINE NUCLEOTIDE EXCHANGE FACTOR K
 
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Ontology Term
Pfam:PF12056 | Protein of unknown function (DUF3537)
Description: This family of transmembrane proteins are functionally uncharacterised. This protein is found in eukaryotes. Proteins in this family are typically between 427 to 453 amino acids in length.
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Ontology Term
Pfam:PF00449 | Urease alpha-subunit, N-terminal domain
Description: The N-terminal domain is a composite domain and plays a major trimer stabilising role by contacting the catalytic domain of the symmetry related alpha-subunit.
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Ontology Term
Pfam:PF00547 | Urease, gamma subunit
Description: Urease is a nickel-binding enzyme that catalyses the hydrolysis of urea to carbon dioxide and ammonia.
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Ontology Term
Pfam:PF00699 | Urease beta subunit
Description: This subunit is known as alpha in Heliobacter.
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Ontology Term
Pfam:PF01979 | Amidohydrolase family
Description: This family of enzymes are a a large metal dependent hydrolase superfamily [1]. The family includes Adenine deaminase EC:3.5.4.2 that hydrolyses adenine to form hypoxanthine and ammonia. Adenine deaminases reaction is important for adenine utilisation as a purine and also as a nitrogen source [2]. This family also includes dihydroorotase and N-acetylglucosamine-6-phosphate deacetylases, EC:3.5.1.25 These enzymes catalyse the reaction N-acetyl-D-glucosamine 6-phosphate + H2O <=> D-glucosamine 6-phosphate + acetate. This family includes the catalytic domain of urease alpha subunit [3]. Dihydroorotases (EC:3.5.2.3) are also included [4-5].
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Ontology Term
Pfam:PF00346 | Respiratory-chain NADH dehydrogenase, 49 Kd subunit
Description: NULL
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Ontology Term
PANTHER:PTHR22849:SF0 | WD REPEAT, SAM AND U-BOX DOMAIN-CONTAINING PROTEIN 1
 
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Ontology Term
PANTHER:PTHR10412 | MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE
 
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Ontology Term
PANTHER:PTHR10412:SF1 | MANNOSYL-OLIGOSACCHARIDE GLUCOSIDASE
 
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Ontology Term
Pfam:PF03200 | Glycosyl hydrolase family 63 C-terminal domain
Description: This is a family of eukaryotic enzymes belonging to glycosyl hydrolase family 63. They catalyse the specific cleavage of the non-reducing terminal glucose residue from Glc(3)Man(9)GlcNAc(2). Mannosyl oligosaccharide glucosidase EC:3.2.1.106 is the first enzyme in the N-linked oligosaccharide processing pathway. This family represents the C-terminal catalytic domain [1].
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Ontology Term
PANTHER:PTHR12147 | METALLOPEPTIDASE M28 FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR12147:SF6 | ENDOPLASMIC RETICULUM METALLOPEPTIDASE 1
 
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Ontology Term
Pfam:PF04389 | Peptidase family M28
Description: NULL
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Ontology Term
PANTHER:PTHR26379 | BTB/POZ AND MATH DOMAIN-CONTAINING PROTEIN 1
 
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Ontology Term
PANTHER:PTHR13202 | MICROSOMAL SIGNAL PEPTIDASE 12 KDA SUBUNIT
 
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Ontology Term
PANTHER:PTHR13202:SF0 | SIGNAL PEPTIDASE COMPLEX SUBUNIT 1
 
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Ontology Term
Pfam:PF06645 | Microsomal signal peptidase 12 kDa subunit (SPC12)
Description: This family consists of several microsomal signal peptidase 12 kDa subunit proteins. Translocation of polypeptide chains across the endoplasmic reticulum (ER) membrane is triggered by signal sequences. Subsequently, signal recognition particle interacts with its membrane receptor and the ribosome-bound nascent chain is targeted to the ER where it is transferred into a protein-conducting channel. At some point, a second signal sequence recognition event takes place in the membrane and translocation of the nascent chain through the membrane occurs. The signal sequence of most secretory and membrane proteins is cleaved off at this stage. Cleavage occurs by the signal peptidase complex (SPC) as soon as the lumenal domain of the translocating polypeptide is large enough to expose its cleavage site to the enzyme. The signal peptidase complex is possibly also involved in proteolytic events in the ER membrane other than the processing of the signal sequence, for example the further digestion of the cleaved signal peptide or the degradation of membrane proteins. Mammalian signal peptidase is as a complex of five different polypeptide chains. This family represents the 12 kDa subunit (SPC12).
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Ontology Term
PANTHER:PTHR11593 | 60S RIBOSOMAL PROTEIN L17
 
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Ontology Term
Pfam:PF00237 | Ribosomal protein L22p/L17e
Description: This family includes L22 from prokaryotes and chloroplasts and L17 from eukaryotes.
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Ontology Term
PANTHER:PTHR15601 | STRESS ASSOCIATED ENDOPLASMIC RETICULUM PROTEIN SERP1/RAMP4
 
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Ontology Term
Pfam:PF06624 | Ribosome associated membrane protein RAMP4
Description: This family consists of several ribosome associated membrane protein RAMP4 (or SERP1) sequences. Stabilisation of membrane proteins in response to stress involves the concerted action of a rescue unit in the ER membrane comprised of SERP1/RAMP4, other components of the translocon, and molecular chaperones in the ER [1].
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Ontology Term
PANTHER:PTHR12612 | NUCLEAR TRANSPORT FACTOR 2
 
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Ontology Term
Pfam:PF11820 | Protein of unknown function (DUF3339)
Description: This family of proteins are functionally uncharacterised. This family is found in eukaryotes. Proteins in this family are about 70 amino acids in length.
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Ontology Term
Pfam:PF00319 | SRF-type transcription factor (DNA-binding and dimerisation domain)
Description: NULL
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Ontology Term
PANTHER:PTHR22950:SF60 | PROTEIN Y18D10A.23
 
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Ontology Term
PANTHER:PTHR10980 | RHO GDP-DISSOCIATION INHIBITOR
 
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Ontology Term
Pfam:PF02115 | RHO protein GDP dissociation inhibitor
Description: NULL
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Ontology Term
PANTHER:PTHR10553 | SMALL NUCLEAR RIBONUCLEOPROTEIN
 
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Ontology Term
PANTHER:PTHR11895:SF8 | AMIDASE FAMILY PROTEIN
 
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Ontology Term
Pfam:PF04278 | Tic22-like family
Description: The preprotein translocation at the inner envelope membrane of chloroplasts so far involves five proteins: Tic110, Tic55, Tic40, Tic22 (this family) and Tic20. The molecular function of these proteins has not yet been established [1].
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Ontology Term
PANTHER:PTHR21499 | ASPARTATE KINASE
 
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Ontology Term
PANTHER:PTHR21499:SF1 | HOMOSERINE DEHYDROGENASE
 
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Ontology Term
Pfam:PF03447 | Homoserine dehydrogenase, NAD binding domain
Description: This domain adopts a Rossmann NAD binding fold. The C-terminal domain of homoserine dehydrogenase contributes a single helix to this structural domain, which is not included in the Pfam model.
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Ontology Term
Pfam:PF13840 | ACT domain
Description: The ACT domain is a structural motif of 70-90 amino acids that functions in the control of metabolism, solute transport and signal transduction. They are thus found in a variety of different proteins in a variety of different arrangements [1]. In mammalian phenylalanine hydroxylase the domain forms no contacts but promotes an allosteric effect despite the apparent lack of ligand binding [2].
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Ontology Term
PANTHER:PTHR23300 | METHANETHIOL OXIDASE
 
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Ontology Term
PANTHER:PTHR23300:SF0 | METHANETHIOL OXIDASE
 
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Ontology Term
Pfam:PF05694 | 56kDa selenium binding protein (SBP56)
Description: This family consists of several eukaryotic selenium binding proteins as well as three sequences from archaea. The exact function of this protein is unknown although it is thought that SBP56 participates in late stages of intra-Golgi protein transport [1]. The Lotus japonicus homologue of SBP56, LjSBP is thought to have more than one physiological role and can be implicated in controlling the oxidation/reduction status of target proteins, in vesicular Golgi transport [2].
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Ontology Term
PANTHER:PTHR15327 | MICROFIBRIL-ASSOCIATED PROTEIN
 
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Ontology Term
Pfam:PF06991 | Microfibril-associated/Pre-mRNA processing
Description: MFAP1 was first named for proteins associated with microfibrils which are an important component of the extracellular matrix (ECM) of many tissues. For example, MFAP1 has been shown to be associated with elastin-like fibres at the base of Schlemm's canal endothelium cells, in the juxtacanalicular tissue, and in the uveal region [3]. Based on its role in the ECM and the proximity of the MFAP1 gene to FBN1 it was hypothesised that mutations in MFAP1 contributed to heritable diseases affecting microfibrils, Marfan syndrome [1] but this has now been shown not to be the case. MFAP1 has also been shown to interact directly with certain pre-mRNA processing factor proteins, Prps, which are also spliceosome components and is thus required for pre-mRNA processing. MAFP1 bound to Pr38 of yeast is necessary for cells in vivo to progress from G2 to M phase [2].
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Ontology Term
PANTHER:PTHR19411 | PROTEIN BUD31-RELATED
 
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Ontology Term
PANTHER:PTHR19411:SF0 | PROTEIN BUD31 HOMOLOG
 
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Ontology Term
Pfam:PF01125 | G10 protein
Description: NULL
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Ontology Term
PANTHER:PTHR23420 | ADENOSYLHOMOCYSTEINASE
 
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Ontology Term
PANTHER:PTHR23420:SF0 | ADENOSYLHOMOCYSTEINASE
 
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Ontology Term
Pfam:PF00670 | S-adenosyl-L-homocysteine hydrolase, NAD binding domain
Description: NULL
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Ontology Term
Pfam:PF05221 | S-adenosyl-L-homocysteine hydrolase
Description: NULL
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Ontology Term
PANTHER:PTHR10795:SF3 | SUBTILASE FAMILY PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR12570 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF05653 | Magnesium transporter NIPA
Description: NIPA (nonimprinted in Prader-Willi/Angelman syndrome) is a family of integral membrane proteins which function as magnesium transporters [1,2].
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Ontology Term
Pfam:PF00630 | Filamin/ABP280 repeat
Description: NULL
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Ontology Term
PANTHER:PTHR11774 | GERANYLGERANYL TRANSFERASE TYPE BETA SUBUNIT
 
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Ontology Term
Pfam:PF00432 | Prenyltransferase and squalene oxidase repeat
Description: NULL
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Ontology Term
PANTHER:PTHR32387 | WU:FJ29H11
 
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Ontology Term
PANTHER:PTHR32387:SF0 | WU:FJ29H11
 
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Ontology Term
Pfam:PF13020 | Protein NO VEIN, C-terminal
Description: This domain of unknown function is found at the C-terminal of Protein NO VEIN from Arabidopsis, a protein essential for cell fate determination during embryogenesis [2]. It mediates this process through an auxin-dependent pathway [3]. This domain is also found in some restriction endonucleases.
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Ontology Term
PANTHER:PTHR22629 | ARP2/3 COMPLEX 20 KD SUBUNIT
 
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Ontology Term
PANTHER:PTHR22629:SF0 | ACTIN-RELATED PROTEIN 2/3 COMPLEX SUBUNIT 4
 
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Ontology Term
Pfam:PF05856 | ARP2/3 complex 20 kDa subunit (ARPC4)
Description: This family consists of several eukaryotic ARP2/3 complex 20 kDa subunit (P20-ARC) proteins. The Arp2/3 protein complex has been implicated in the control of actin polymerisation in cells. The human complex consists of seven subunits which include the actin related proteins Arp2 and Arp3 it has been suggested that the complex promotes actin assembly in lamellipodia and may participate in lamellipodial protrusion [1].
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Ontology Term
PANTHER:PTHR22957:SF27 | TBC1 DOMAIN FAMILY MEMBER 13
 
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Ontology Term
PANTHER:PTHR10562 | SMALL UBIQUITIN-RELATED MODIFIER
 
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Ontology Term
Pfam:PF11976 | Ubiquitin-2 like Rad60 SUMO-like
Description: The small ubiquitin-related modifier SUMO-1 is a Ub/Ubl family member, and although SUMO-1 shares structural similarity to Ub, SUMO's cellular functions remain distinct insomuch as SUMO modification alters protein function through changes in activity, cellular localisation, or by protecting substrates from ubiquitination [1]. Rad60 family members contain functionally enigmatic, integral SUMO-like domains (SLDs). Despite their divergence from SUMO, each Rad60 SLD interacts with a subset of SUMO pathway enzymes: SLD2 specifically binds the SUMO E2 conjugating enzyme (Ubc9)), whereas SLD1 binds the SUMO E1 (Fub2, also called Uba2) activating and E3 (Pli1, also called Siz1 and Siz2) specificity enzymes. Structural analysis of PDB:2uyz reveals a mechanistic basis for the near-synonymous roles of Rad60 and SUMO in survival of genotoxic stress and suggest unprecedented DNA-damage-response functions for SLDs in regulating SUMOylation [2]. The Rad60 branch of this family is also known as RENi (Rad60-Esc2-Nip45), and biologically it should be two distinct families SUMO and RENi (Rad60-Esc2-Nip45).
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Ontology Term
PANTHER:PTHR15157 | UV RADIATION RESISTANCE-ASSOCIATED GENE PROTEIN
 
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Ontology Term
Pfam:PF09409 | PUB domain
Description: The PUB (also known as PUG) domain is found in peptide N-glycanase where it functions as a AAA ATPase binding domain [1]. This domain is also found on other proteins linked to the ubiquitin-proteasome system.
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Ontology Term
PANTHER:PTHR24015:SF239 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR11668:SF21 | SERINE/THREONINE-PROTEIN PHOSPHATASE 2A CATALYTIC SUBUNIT BETA ISOFORM
 
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Ontology Term
PANTHER:PTHR22572:SF8 | TRANSLATION INITIATION FACTOR EIF-2B SUBUNIT GAMMA
 
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Ontology Term
PANTHER:PTHR24095:SF46 | ACETOACETYL-COA SYNTHETASE
 
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Ontology Term
PANTHER:PTHR21266 | IRON-SULFUR DOMAIN CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF00355 | Rieske [2Fe-2S] domain
Description: The rieske domain has a [2Fe-2S] centre. Two conserved cysteines coordinate one Fe ion, while the other Fe ion is coordinated by two conserved histidines. In hyperthermophilic archaea there is a SKTPCX(2-3)C motif at the C-terminus. The cysteines in this motif form a disulphide bridge, which stabilises the protein [4].
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Ontology Term
Pfam:PF08417 | Pheophorbide a oxygenase
Description: This domain is found in bacterial and plant proteins to the C-terminus of a Rieske 2Fe-2S domain (Pfam:PF00355). One of the proteins the domain is found in is Pheophorbide a oxygenase (PaO) which seems to be a key regulator of chlorophyll catabolism. Arabidopsis PaO (AtPaO) is a Rieske-type 2Fe-2S enzyme that is identical to Arabidopsis accelerated cell death 1 and homologous to lethal leaf spot 1 (LLS1) of maize [1], in which the domain described here is also found.
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Ontology Term
PANTHER:PTHR23413 | 60S RIBOSOMAL PROTEIN L32 AND DNA-DIRECTED RNA POLYMERASE II, SUBUNIT N
 
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Ontology Term
Pfam:PF01655 | Ribosomal protein L32
Description: This family includes ribosomal protein L32 from eukaryotes and archaebacteria.
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Ontology Term
PANTHER:PTHR24089:SF39 | MITOCHONDRIAL DICARBOXYLATE CARRIER
 
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