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Search results 3301 to 3400 out of 202262 for *

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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF08038 | TOM7 family
Description: This family consists of TOM7 family of mitochondrial import receptors. TOM7 forms part of the translocase of the outer mitochondrial membrane (TOM) complex and it appears to function as a modulator of the dynamics of the mitochondrial protein transport machinery by promoting the dissociation of subunits of the outer membrane translocase [1].
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Ontology Term
PANTHER:PTHR10390 | HOMEOBOX PROTEIN SIX
 
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Ontology Term
PANTHER:PTHR24220 | IMPORT ATP-BINDING PROTEIN
 
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Ontology Term
PANTHER:PTHR24220:SF85 | ABC TRANSPORTER I FAMILY MEMBER 6, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF02922 | Carbohydrate-binding module 48 (Isoamylase N-terminal domain)
Description: This domain is found in a range of enzymes that act on branched substrates - isoamylase, pullulanase and branching enzyme. This family also contains the beta subunit of 5' AMP activated kinase.
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Ontology Term
PANTHER:PTHR10457:SF6 | GALACTURONOKINASE
 
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Ontology Term
PANTHER:PTHR10151 | ECTONUCLEOTIDE PYROPHOSPHATASE/PHOSPHODIESTERASE
 
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Ontology Term
Pfam:PF01663 | Type I phosphodiesterase / nucleotide pyrophosphatase
Description: This family consists of phosphodiesterases, including human plasma-cell membrane glycoprotein PC-1 / alkaline phosphodiesterase i / nucleotide pyrophosphatase (nppase). These enzymes catalyse the cleavage of phosphodiester and phosphosulfate bonds in NAD, deoxynucleotides and nucleotide sugars [1]. Also in this family is ATX an autotaxin, tumour cell motility-stimulating protein which exhibits type I phosphodiesterases activity [4]. The alignment encompasses the active site [3,4]. Also present with in this family is 60-kDa Ca2+-ATPase form F. odoratum [2].
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Ontology Term
PANTHER:PTHR11644 | CYTIDINE DEAMINASE
 
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Ontology Term
Pfam:PF00383 | Cytidine and deoxycytidylate deaminase zinc-binding region
Description: NULL
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Ontology Term
Pfam:PF08211 | Cytidine and deoxycytidylate deaminase zinc-binding region
Description: NULL
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Ontology Term
PANTHER:PTHR11034 | N-MYC DOWNSTREAM REGULATED
 
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Ontology Term
Pfam:PF03096 | Ndr family
Description: This family consists of proteins from different gene families: Ndr1/RTP/Drg1, Ndr2, and Ndr3. Their similarity was previously noted [1]. The precise molecular and cellular function of members of this family is still unknown. Yet, they are known to be involved in cellular differentiation events. The Ndr1 group was the first to be discovered. Their expression is repressed by the proto-oncogenes N-myc and c-myc, and in line with this observation, Ndr1 protein expression is down-regulated in neoplastic cells, and is reactivated when differentiation is induced by chemicals such as retinoic acid. Ndr2 and Ndr3 expression is not under the control of N-myc or c-myc. Ndr1 expression is also activated by several chemicals: tunicamycin and homocysteine induce Ndr1 in human umbilical endothelial cells; nickel induces Ndr1 in several cell types. Members of this family are found in wide variety of multicellular eukaryotes, including an Ndr1 type protein in Helianthus annuus (sunflower), known as Sf21 Swiss:O23969. Interestingly, the highest scoring matches in the noise are all alpha/beta hydrolases Pfam:PF00561, suggesting that this family may have an enzymatic function (Bateman A pers. obs.).
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Ontology Term
PANTHER:PTHR10804:SF17 | XAA-PRO DIPEPTIDASE
 
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Ontology Term
Pfam:PF05195 | Aminopeptidase P, N-terminal domain
Description: This domain is structurally very similar [1] to the creatinase N-terminal domain (Pfam:PF01321). However, little or no sequence similarity exists between the two families.
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Ontology Term
PANTHER:PTHR10956 | 60S RIBOSOMAL PROTEIN L31
 
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Ontology Term
Pfam:PF01198 | Ribosomal protein L31e
Description: NULL
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Ontology Term
PANTHER:PTHR22594:SF6 | ASPARAGINE--TRNA LIGASE, MITOCHONDRIAL-RELATED
 
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Ontology Term
PANTHER:PTHR12588 | MYOINOSITOL OXYGENASE
 
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Ontology Term
PANTHER:PTHR12588:SF0 | INOSITOL OXYGENASE
 
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Ontology Term
Pfam:PF05153 | Myo-inositol oxygenase
Description: MIOX is the enzyme myo-inositol oxygenase. It catalyses the first committed step in the glucuronate-xylulose pathway, It is a di-iron oxygenase with a key role in inositol metabolism. The structure reveals a monomeric, single-domain protein with a mostly helical fold that is distantly related to the diverse HD domain superfamily. The structural core is of five alpha-helices that contribute six ligands, four His and two Asp, to the di-iron centre where the two iron atoms are bridged by a putative hydroxide ion and one of the Asp ligands. The substrate is myo-inositol is bound in a terminal substrate-binding mode to a di-iron cluster [1]. Within the structure are two additional proteinous lids that cover and shield the enzyme's active site [2].
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Ontology Term
PANTHER:PTHR11753 | ADAPTOR COMPLEXES SMALL SUBUNIT FAMILY
 
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Ontology Term
PANTHER:PTHR10159 | DUAL SPECIFICITY PROTEIN PHOSPHATASE
 
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Ontology Term
PANTHER:PTHR10159:SF5 | MAP KINASE PHOSPHATASE-1
 
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Ontology Term
PANTHER:PTHR31317 | OS08G0163500 PROTEIN
 
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Ontology Term
Pfam:PF06219 | Protein of unknown function (DUF1005)
Description: Family of plant proteins with undetermined function.
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Ontology Term
PANTHER:PTHR11009 | DER1-LIKE PROTEIN, DERLIN
 
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Ontology Term
PANTHER:PTHR11009:SF0 | DERLIN-2.2
 
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Ontology Term
Pfam:PF04511 | Der1-like family
Description: The endoplasmic reticulum (ER) of the yeast Saccharomyces cerevisiae contains of proteolytic system able to selectively degrade misfolded lumenal secretory proteins. For examination of the components involved in this degradation process, mutants were isolated. They could be divided into four complementation groups. The mutations led to stabilisation of two different substrates for this process. The mutant classes were called 'der' for 'degradation in the ER'. DER1 was cloned by complementation of the der1-2 mutation. The DER1 gene codes for a novel, hydrophobic protein, that is localised to the ER. Deletion of DER1 abolished degradation of the substrate proteins. The function of the Der1 protein seems to be specifically required for the degradation process associated with the ER [1]. Interestingly this family seems distantly related to the Rhomboid family of membrane peptidases. Suggesting that this family may also mediate degradation of misfolded proteins (Bateman A pers. obs.).
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Ontology Term
PANTHER:PTHR11604:SF0 | PROFILIN
 
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Ontology Term
PANTHER:PTHR22981 | 3-HYDROXYISOBUTYRATE DEHYDROGENASE-RELATED
 
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Ontology Term
Pfam:PF03446 | NAD binding domain of 6-phosphogluconate dehydrogenase
Description: The NAD binding domain of 6-phosphogluconate dehydrogenase adopts a Rossmann fold.
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Ontology Term
Pfam:PF14833 | NAD-binding of NADP-dependent 3-hydroxyisobutyrate dehydrogenase
Description: 3-Hydroxyisobutyrate is a central metabolite in the valine catabolic pathway, and is reversibly oxidised to methylmalonate semi-aldehyde by a specific dehydrogenase belonging to the 3-hydroxyacid dehydrogenase family. The reaction is NADP-dependent and this region of the enzyme binds NAD. The NAD-binding domain of 6-phosphogluconate dehydrogenase adopts an alpha helical structure [1].
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Ontology Term
PANTHER:PTHR12029:SF7 | RRNA METHYLTRANSFERASE 1, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF08032 | RNA 2'-O ribose methyltransferase substrate binding
Description: This domain is a RNA 2'-O ribose methyltransferase substrate binding domain.
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Ontology Term
PANTHER:PTHR12726 | CERAMIDE GLUCOSYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR12726:SF0 | CERAMIDE GLUCOSYLTRANSFERASE
 
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Ontology Term
Pfam:PF13506 | Glycosyl transferase family 21
Description: This is a family of ceramide beta-glucosyltransferases - EC:2.4.1.80.
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Ontology Term
PANTHER:PTHR21068 | SPARTIN
 
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Ontology Term
PANTHER:PTHR21068:SF5 | SENESCENCE/DEHYDRATION-ASSOCIATED PROTEIN-LIKE PROTEIN
 
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Ontology Term
PANTHER:PTHR31811 | TRNA A64-2'-O-RIBOSYLPHOSPHATE TRANSFERASE
 
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Ontology Term
Pfam:PF04179 | Rit1 DUSP-like domain
Description: This enzyme (EC:2.4.2.-) modifies exclusively the initiator tRNA in position 64 using 5'-phosphoribosyl-1'-pyrophosphate as the modification donor. As the initiator tRNA participates both in the initiation and elongation of translation, the 2'-O-ribosyl phosphate modification discriminates the initiator tRNAs from the elongator tRNAs [1]. This C-terminal domain shows similarity to dual specificity phosphatases [2].
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Ontology Term
Pfam:PF12678 | RING-H2 zinc finger domain
Description: There are 8 cysteine/ histidine residues which are proposed to be the conserved residues involved in zinc binding. The protein, of which this domain is the conserved region, participates in diverse functions relevant to chromosome metabolism and cell cycle control [1].
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Ontology Term
PANTHER:PTHR12315 | BICOID-INTERACTING PROTEIN RELATED
 
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Ontology Term
PANTHER:PTHR12315:SF0 | 7SK SNRNA METHYLPHOSPHATE CAPPING ENZYME
 
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Ontology Term
Pfam:PF06859 | Bicoid-interacting protein 3 (Bin3)
Description: This family represents a conserved region of approximately 120 residues within eukaryotic Bicoid-interacting protein 3 (Bin3). Bin3, which shows similarity to a number of protein methyltransferases that modify RNA-binding proteins, interacts with Bicoid, which itself directs pattern formation in the early Drosophila embryo. The interaction might allow Bicoid to switch between its dual roles in transcription and translation [1]. Note that family members contain a conserved HLN motif.
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Ontology Term
Pfam:PF10639 | Putative transmembrane family 234
Description: TMEM234 is a family of putative inner membrane proteins. Many bacterial members are annotated as putative L-Ara4N-phosphoundecaprenol flippase subunit ArnE, and as inner membrane proteins. They may be transporters of the multi-drug-resistant superfamily.
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Ontology Term
Pfam:PF03638 | Tesmin/TSO1-like CXC domain, cysteine-rich domain
Description: This family includes proteins that have two copies of a cysteine rich motif as follows: C-X-C-X4-C-X3-YC-X-C-X6-C-X3-C-X-C-X2-C. The family includes Tesmin Swiss:Q9Y4I5 [1] and TSO1 Swiss:Q9LE32 [2]. This family is called a CXC domain in [2].
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Ontology Term
PANTHER:PTHR24073:SF132 | DRAB5
 
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Ontology Term
PANTHER:PTHR31791 | FRIGIDA-LIKE PROTEIN 3-RELATED
 
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Ontology Term
Pfam:PF07899 | Frigida-like protein
Description: This family is composed of plant proteins that are similar to FRIGIDA protein expressed by Arabidopsis thaliana (Swiss:Q9FDW0). This protein is probably nuclear and is required for the regulation of flowering time in the late-flowering phenotype. It is known to increase RNA levels of flowering locus C. Allelic variation at the FRIGIDA locus is a major determinant of natural variation in flowering time [1].
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Ontology Term
PANTHER:PTHR32093 | LEUCINE-RICH REPEAT EXTENSIN-LIKE PROTEIN 3-RELATED
 
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Ontology Term
PANTHER:PTHR21736:SF17 | EMB|CAB52464.1
 
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Ontology Term
Pfam:PF00041 | Fibronectin type III domain
Description: NULL
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Ontology Term
PANTHER:PTHR11005 | LYSOSOMAL ACID LIPASE-RELATED
 
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Ontology Term
Pfam:PF04083 | Partial alpha/beta-hydrolase lipase region
Description: This family corresponds to a N-terminal part of an alpha/beta hydrolase domain.
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Ontology Term
PANTHER:PTHR12121 | CARBON CATABOLITE REPRESSOR PROTEIN 4
 
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Ontology Term
PANTHER:PTHR17224 | PEPTIDYL-TRNA HYDROLASE
 
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Ontology Term
Pfam:PF01195 | Peptidyl-tRNA hydrolase
Description: NULL
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Ontology Term
PANTHER:PTHR31874 | CCT MOTIF FAMILY PROTEIN, EXPRESSED
 
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Ontology Term
PANTHER:PTHR10759 | 60S RIBOSOMAL PROTEIN L34
 
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Ontology Term
PANTHER:PTHR10759:SF1 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF07891 | Protein of unknown function (DUF1666)
Description: These sequences are derived from hypothetical plant proteins of unknown function. The region in question is approximately 250 residues long.
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Ontology Term
PANTHER:PTHR31744 | PROTEIN CUP-SHAPED COTYLEDON 2-RELATED
 
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Ontology Term
Pfam:PF14304 | Transcription termination and cleavage factor C-terminal
Description: The C-terminal section of CSTF proteins is a discreet structure is crucial for mRNA 3'-end processing. This domain interacts with Pcf11 and possibly PC4, thus linking CstF2 to transcription, transcriptional termination, and cell growth.
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Ontology Term
PANTHER:PTHR12722 | XAP-5 PROTEIN-RELATED
 
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Ontology Term
Pfam:PF04921 | XAP5, circadian clock regulator
Description: This protein is found in a wide range of eukaryotes. It is a nuclear protein previously suggested to be DNA binding [1,2] but recent studies suggest that they play a role in the spliceosome complex [3]. In plants, this family is essential for correct circadian clock functioning by acting as a light-quality regulator coordinating the activities of blue and red light signalling pathways during plant growth - inhibiting growth in red light but promoting growth in blue light [4].
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Ontology Term
Pfam:PF00203 | Ribosomal protein S19
Description: NULL
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Ontology Term
PANTHER:PTHR11476 | HISTIDYL-TRNA SYNTHETASE
 
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Ontology Term
Pfam:PF00221 | Aromatic amino acid lyase
Description: This family includes proteins with phenylalanine ammonia-lyase, EC:4.3.1.24, histidine ammonia-lyase, EC:4.3.1.3, and tyrosine aminomutase, EC:5.4.3.6, activities [1-3].
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Ontology Term
PANTHER:PTHR23153 | UBX-RELATED
 
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Ontology Term
Pfam:PF00789 | UBX domain
Description: This domain is present in ubiquitin-regulatory proteins and is a general Cdc48-interacting module [2].
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Ontology Term
PANTHER:PTHR11587 | ARGININOSUCCINATE SYNTHASE
 
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Ontology Term
Pfam:PF00764 | Arginosuccinate synthase
Description: This family contains a PP-loop motif [1].
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Ontology Term
PANTHER:PTHR10849 | NADH DEHYDROGENASE UBIQUINONE IRON-SULFUR PROTEIN 8, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF12838 | 4Fe-4S dicluster domain
Description: Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members include bacterial ferredoxins, various dehydrogenases, and various reductases. Structure of the domain is an alpha-antiparallel beta sandwich. Domain contains two 4Fe4S clusters.
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Ontology Term
PANTHER:PTHR31426 | GROUP II INTRON SPLICING FACTOR CRS1-LIKE
 
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Ontology Term
PANTHER:PTHR22594:SF5 | ASPARTATE--TRNA LIGASE, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF02878 | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain I
Description: NULL
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Ontology Term
Pfam:PF02880 | Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III
Description: NULL
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Ontology Term
Pfam:PF14380 | Wall-associated receptor kinase C-terminal
Description: This WAK_assoc domain is cysteine-rich and lies C-terminal to the binding domain, GUB_WAK_bind, Pfam:PF13947.
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Ontology Term
PANTHER:PTHR31042 | CORE-2/I-BRANCHING BETA-1,6-N-ACETYLGLUCOSAMINYLTRANSFERASE FAMILY PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR22781 | DELTA ADAPTIN-RELATED
 
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Ontology Term
PANTHER:PTHR21319 | RING FINGER AND CHY ZINC FINGER DOMAIN-CONTAINING PROTEIN 1
 
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Ontology Term
Pfam:PF01814 | Hemerythrin HHE cation binding domain
Description: Iteration of the HHE family ([2]) found it to be related to Hemerythrin. It also demonstrated that what has been described as a single domain ([1]) in fact consists of two cation binding domains. Members of this family occur all across nature and are involved in a variety of processes. For instance, in Nereis diversicolor Swiss:P80255 binds Cadmium so as to protect the organism from toxicity ([3]). However Hemerythrin is classically described as Oxygen-binding through two attached Fe2+ ions. And the bacterial Swiss:Q7WX96 is a regulator of response to NO, which suggests yet another set-up for its metal ligands ([4]). In Staphylococcus aureus P72360 has been noted to be important when the organism switches to living in environments with low oxygen concentrations ([4]); perhaps this protein acts as an oxygen store or scavenger. This domain can bind oxygen (Matilla et.al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043)
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Ontology Term
Pfam:PF05495 | CHY zinc finger
Description: This family of domains are likely to bind to zinc ions. They contain many conserved cysteine and histidine residues. We have named this domain after the N-terminal motif CXHY. This domain can be found in isolation in some proteins, but is also often associated with Pfam:PF00097. One of the proteins in this family (Swiss:P36078) is a mitochondrial intermembrane space protein called Hot13. This protein is involved in the assembly of small TIM complexes [1].
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Ontology Term
Pfam:PF14599 | Zinc-ribbon
Description: This is a typical zinc-ribbon finger, with each pair of zinc-ligands coming from more-or-less either side of two knuckles. It is found in eukaryotes.
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Ontology Term
Pfam:PF07797 | Protein of unknown function (DUF1639)
Description: This approximately 50 residue region is found in a number of sequences derived from hypothetical plant proteins. This region features a highly basic 5 amino-acid stretch towards its centre.
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Ontology Term
PANTHER:PTHR12096 | NUCLEAR PROTEIN SKIP-RELATED
 
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Ontology Term
PANTHER:PTHR12096:SF0 | SNW DOMAIN-CONTAINING PROTEIN 1
 
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Ontology Term
Pfam:PF02731 | SKIP/SNW domain
Description: This domain is found in chromatin proteins.
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Ontology Term
Pfam:PF08969 | USP8 dimerisation domain
Description: This domain is predominantly found in the amino terminal region of Ubiquitin carboxyl-terminal hydrolase 8 (USP8). It forms a five helical bundle that dimerises [1].
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Ontology Term
Pfam:PF13398 | Peptidase M50B-like
Description: This is a family of bacterial and plant peptidases in the same family as MEROPS:M50B.
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Ontology Term
PANTHER:PTHR11278 | 40S RIBOSOMAL PROTEIN S7
 
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Ontology Term
Pfam:PF01251 | Ribosomal protein S7e
Description: NULL
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Ontology Term
PANTHER:PTHR12629 | DIPHOSPHOINOSITOL POLYPHOSPHATE PHOSPHOHYDROLASE
 
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Ontology Term
PANTHER:PTHR12629:SF0 | NUDIX HYDROLASE DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR16023 | TAX1 BINDING PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR16023:SF0 | PROTEIN VAC14 HOMOLOG
 
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Ontology Term
Pfam:PF11916 | Vacuolar protein 14 C-terminal Fig4p binding
Description: Vac14 is a scaffold for the Fab1 kinase complex, a complex that allows for the dynamic interconversion of PI3P and PI(3,5)P2p (phosphoinositide phosphate (PIP) lipids, that are generated transiently on the cytoplasmic face of selected intracellular membranes). This interconversion is regulated by at least five proteins in yeast: the lipid kinase Fab1p, lipid phosphatase Fig4p, the Fab1p activator Vac7p, the Fab1p inhibitor Atg18p, and Vac14p, a protein required for the activity of both Fab1p and Fig4p. The C-terminal region of Vac14 binds to Fig4p. The full length Vac14 in yeasts is likely to be a protein carrying a succession of HEAT repeats, most of which have now degenerated. This regulatory system is crucial for the proper functioning of the mammalian nervous system.
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