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Search results 41801 to 41900 out of 44733 for *

Category restricted to GOTerm (x)

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Categories

Category: GOTerm
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Type Details Score
GO Term
GO:0010884 | positive regulation of lipid storage
Description: Any process that increases the rate, frequency or extent of lipid storage. Lipid storage is the accumulation and maintenance in cells or tissues of lipids, compounds soluble in organic solvents but insoluble or sparingly soluble in aqueous solvents. Lipid reserves can be accumulated during early developmental stages for mobilization and utilization at later stages of development.
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GO Term
GO:0042974 | retinoic acid receptor binding
Description: Interacting selectively and non-covalently with the retinoic acid receptor, a ligand-regulated transcription factor belonging to the nuclear receptor superfamily.
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GO Term
GO:0045523 | interleukin-27 receptor binding
Description: Interacting selectively and non-covalently with the interleukin-27 receptor.
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GO Term
GO:0042129 | regulation of T cell proliferation
Description: Any process that modulates the frequency, rate or extent of T cell proliferation.
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GO Term
GO:0055074 | calcium ion homeostasis
Description: Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell.
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GO Term
GO:0007098 | centrosome cycle
Description: The cell cycle process in which centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle.
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GO Term
GO:0000725 | recombinational repair
Description: A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA.
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GO Term
GO:0031573 | intra-S DNA damage checkpoint
Description: A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.
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GO Term
GO:0005112 | Notch binding
Description: Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor.
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GO Term
GO:0019171 | 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity
Description: Catalysis of the reaction: a (3R)-3-hydroxyacyl-[acyl-carrier protein] = H2O + a trans-delta2-enoyl-acyl-[acyl-carrier protein].
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GO Term
GO:0030659 | cytoplasmic vesicle membrane
Description: The lipid bilayer surrounding a cytoplasmic vesicle.
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GO Term
GO:0008157 | protein phosphatase 1 binding
Description: Interacting selectively and non-covalently with the enzyme protein phosphatase 1.
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GO Term
GO:0071797 | LUBAC complex
Description: A ubiquitin ligase complex that catalyzes linear head-to-tail polyubiquitin conjugation on its targets. In human the complex consists of RBCK1, RNF31 and SHARPIN, and has an MW of approximately 600 kDa, suggesting a heteromultimeric assembly of its subunits. LUBAC stands for Linear Ubiquitin Chain Assembly Complex.
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GO Term
GO:0008746 | NAD(P)+ transhydrogenase activity
Description: Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+.
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GO Term
GO:0044010 | single-species biofilm formation
Description: A process in which planktonically growing microorganisms of the same species grow at a liquid-air interface or on a solid substrate under the flow of a liquid and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.
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GO Term
GO:0004035 | alkaline phosphatase activity
Description: Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum.
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GO Term
GO:0015221 | lipopolysaccharide transmembrane transporter activity
Description: Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide.
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GO Term
GO:0042882 | L-arabinose transmembrane transport
Description: The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other.
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GO Term
GO:0004793 | threonine aldolase activity
Description: Catalysis of the reaction: L-threonine = glycine + acetaldehyde.
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GO Term
GO:0031317 | tripartite ATP-independent periplasmic transporter complex
Description: A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients.
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GO Term
GO:0005041 | low-density lipoprotein particle receptor activity
Description: Combining with a low-density lipoprotein particle and delivering the low-density lipoprotein particle into the cell via endocytosis.
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GO Term
GO:0030307 | positive regulation of cell growth
Description: Any process that activates or increases the frequency, rate, extent or direction of cell growth.
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GO Term
GO:0030335 | positive regulation of cell migration
Description: Any process that activates or increases the frequency, rate or extent of cell migration.
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GO Term
GO:0034097 | response to cytokine
Description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokine stimulus.
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GO Term
GO:0034341 | response to interferon-gamma
Description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-gamma stimulus. Interferon-gamma is also known as type II interferon.
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GO Term
GO:0034612 | response to tumor necrosis factor
Description: Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a tumor necrosis factor stimulus.
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GO Term
GO:0048247 | lymphocyte chemotaxis
Description: The directed movement of a lymphocyte in response to an external stimulus.
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GO Term
GO:0043825 | succinylornithine transaminase activity
Description: Catalysis of the reaction: 2-oxoglutarate + N(2)-succinyl-L-ornithine = N-succinyl-L-glutamate 5-semialdehyde + L-glutamate.
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GO Term
GO:0006593 | ornithine catabolic process
Description: The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.
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GO Term
GO:0052837 | thiazole biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of a thiazole, a five-membered heterocyclic ring structure containing a sulfur in the 1-position and a nitrogen in the 3-position.
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GO Term
GO:0019531 | oxalate transmembrane transporter activity
Description: Enables the transfer of oxalate from one side of a membrane to the other. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
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GO Term
GO:0019532 | oxalate transport
Description: The directed movement of oxalate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oxalate, or ethanedioic acid, occurs in many plants and is highly toxic to animals.
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GO Term
GO:0002094 | polyprenyltransferase activity
Description: Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor).
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GO Term
GO:0046474 | glycerophospholipid biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue.
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GO Term
GO:0018240 | protein S-linked glycosylation via cysteine
Description: The glycosylation of protein via the sulfur atom of peptidyl-cysteine, forming S-glycosyl-L-cysteine.
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GO Term
GO:0080048 | GDP-D-glucose phosphorylase activity
Description: Catalysis of the reaction: GDP-D-glucose + phosphate = D-glucose-1-P + GDP.
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GO Term
GO:0005879 | axonemal microtubule
Description: A microtubule in the axoneme of a eukaryotic cilium or flagellum; an axoneme contains nine modified doublet microtubules, which may or may not surround a pair of single microtubules.
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GO Term
GO:0047936 | glucose 1-dehydrogenase [NAD(P)] activity
Description: Catalysis of the reaction: beta-D-glucose + NAD(P)+ = D-glucono-1,5-lactone + NAD(P)H.
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GO Term
GO:0034979 | NAD-dependent protein deacetylase activity
Description: Catalysis of the removal of one or more acetyl groups from a protein, requiring NAD.
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GO Term
GO:0019216 | regulation of lipid metabolic process
Description: Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving lipids.
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GO Term
GO:0070328 | triglyceride homeostasis
Description: Any process involved in the maintenance of an internal steady state of triglyceride within an organism or cell.
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GO Term
GO:0007140 | male meiotic nuclear division
Description: A cell cycle process by which the cell nucleus divides as part of a meiotic cell cycle in the male germline.
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GO Term
GO:0010569 | regulation of double-strand break repair via homologous recombination
Description: Any process that modulates the frequency, rate or extent of the error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences.
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GO Term
GO:0008476 | protein-tyrosine sulfotransferase activity
Description: Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate.
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GO Term
GO:0006478 | peptidyl-tyrosine sulfation
Description: The sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine.
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GO Term
GO:0070193 | synaptonemal complex organization
Description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a synaptonemal complex. A synaptonemal complex is a proteinaceous scaffold formed between homologous chromosomes during meiosis.
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GO Term
GO:0048011 | neurotrophin TRK receptor signaling pathway
Description: A series of molecular signals initiated by the binding of a neurotrophin to a receptor on the surface of the target cell where the receptor possesses tyrosine kinase activity, and ending with regulation of a downstream cellular process, e.g. transcription.
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GO Term
GO:0070286 | axonemal dynein complex assembly
Description: The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein complex, a dynein complex found in eukaryotic cilia and flagella, in which the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion.
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GO Term
GO:0043984 | histone H4-K16 acetylation
Description: The modification of histone H4 by the addition of an acetyl group to a lysine residue at position 16 of the histone.
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GO Term
GO:0072487 | MSL complex
Description: A histone acetyltransferase complex that catalyzes the acetylation of a histone H4 lysine residue at position 16. In human, it contains the catalytic subunit MOF, and MSL1, MSL2 and MSL3.
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GO Term
GO:0014065 | phosphatidylinositol 3-kinase signaling
Description: A series of reactions within the signal-receiving cell, mediated by the intracellular phosphatidylinositol 3-kinase (PI3K). Many cell surface receptor linked signaling pathways signal through PI3K to regulate numerous cellular functions.
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GO Term
GO:0048812 | neuron projection morphogenesis
Description: The process in which the anatomical structures of a neuron projection are generated and organized. A neuron projection is any process extending from a neural cell, such as axons or dendrites.
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GO Term
GO:0007051 | spindle organization
Description: A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart.
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GO Term
GO:0007340 | acrosome reaction
Description: The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida of the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the zona pellucida.
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GO Term
GO:0040001 | establishment of mitotic spindle localization
Description: The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.
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GO Term
GO:0000940 | condensed chromosome outer kinetochore
Description: The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions.
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GO Term
GO:0043332 | mating projection tip
Description: The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
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GO Term
GO:2000431 | regulation of cytokinesis, actomyosin contractile ring assembly
Description: Any process that modulates the frequency, rate or extent of cytokinesis, actomyosin contractile ring assembly.
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GO Term
GO:0070772 | PAS complex
Description: A class III phosphatidylinositol 3-kinase complex that contains a phosphatidylinositol-3-phosphate 5-kinase subunit (Fab1p in yeast; PIKfyve in mammals), a kinase activator, and a phosphatase, and may also contain additional proteins; it is involved in regulating the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate. In mammals the complex is composed of PIKFYVE, FIG4 and VAC14. In yeast it is composed of Atg18p, Fig4p, Fab1p, Vac14p and Vac7p.
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GO Term
GO:0001540 | amyloid-beta binding
Description: Interacting selectively and non-covalently with amyloid-beta peptide/protein and/or its precursor.
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GO Term
GO:0042988 | X11-like protein binding
Description: Interacting selectively and non-covalently with X11-like protein, a neuron-specific adaptor protein.
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GO Term
GO:0047570 | 3-oxoadipate enol-lactonase activity
Description: Catalysis of the reaction: 3-oxoadipate enol-lactone + H2O = 3-oxoadipate.
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GO Term
GO:0042952 | beta-ketoadipate pathway
Description: A pathway of aromatic compound degradation by ortho-cleavage; one branch converts protocatechuate, derived from phenolic compounds, to beta-ketoadipate, and the other branch converts catechol, generated from various aromatic hydrocarbons, amino aromatics, and lignin monomers, also to beta-ketoadipate. Two additional steps accomplish the conversion of beta-ketoadipate to tricarboxylic acid cycle intermediates.
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GO Term
GO:0045505 | dynein intermediate chain binding
Description: Interacting selectively and non-covalently with an intermediate chain of the dynein complex.
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GO Term
GO:0051959 | dynein light intermediate chain binding
Description: Interacting selectively and non-covalently with a light intermediate chain of the dynein complex.
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GO Term
GO:0019992 | diacylglycerol binding
Description: Interacting selectively and non-covalently with diacylglycerol, a diester of glycerol and two fatty acids.
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GO Term
GO:0043001 | Golgi to plasma membrane protein transport
Description: The directed movement of proteins from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane.
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GO Term
GO:0017080 | sodium channel regulator activity
Description: Modulates the activity of a sodium channel.
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GO Term
GO:0001817 | regulation of cytokine production
Description: Any process that modulates the frequency, rate, or extent of production of a cytokine.
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GO Term
GO:0008063 | Toll signaling pathway
Description: A series of molecular signals initiated by the binding of an extracellular ligand to the receptor Toll on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription.
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GO Term
GO:0032088 | negative regulation of NF-kappaB transcription factor activity
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.
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GO Term
GO:0050688 | regulation of defense response to virus
Description: Any process that modulates the frequency, rate or extent of the antiviral response of a cell or organism.
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GO Term
GO:0006896 | Golgi to vacuole transport
Description: The directed movement of substances from the Golgi to the vacuole.
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GO Term
GO:0030215 | semaphorin receptor binding
Description: Interacting selectively and non-covalently with semaphorin receptors.
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GO Term
GO:0030837 | negative regulation of actin filament polymerization
Description: Any process that stops, prevents, or reduces the frequency, rate or extent of actin polymerization.
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GO Term
GO:0007254 | JNK cascade
Description: An intracellular protein kinase cascade containing at least a JNK (a MAPK), a JNKK (a MAPKK) and a JUN3K (a MAP3K). The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.
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GO Term
GO:0051092 | positive regulation of NF-kappaB transcription factor activity
Description: Any process that activates or increases the frequency, rate or extent of activity of the transcription factor NF-kappaB.
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GO Term
GO:0030214 | hyaluronan catabolic process
Description: The chemical reactions and pathways resulting in the breakdown of hyaluronan, the naturally occurring anionic form of hyaluronic acid, any member of a group of glycosaminoglycans, the repeat units of which consist of beta-1,4 linked D-glucuronyl-beta-(1,3)-N-acetyl-D-glucosamine.
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GO Term
GO:0038093 | Fc receptor signaling pathway
Description: A series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a signal-receiving cell, and ending with regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.
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GO Term
GO:0038109 | Kit signaling pathway
Description: A series of molecular signals that starts with the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a cell, and ends with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.
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GO Term
GO:0004699 | calcium-independent protein kinase C activity
Description: Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein. This reaction requires diacylglycerol but not calcium.
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GO Term
GO:0004754 | saccharopine dehydrogenase (NAD+, L-lysine-forming) activity
Description: Catalysis of the reaction: L-saccharopine + H(2)O + NAD(+) = 2-oxoglutarate + L-lysine + H(+) + NADH.
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GO Term
GO:0008116 | prostaglandin-I synthase activity
Description: Catalysis of the reaction: prostaglandin H(2) = prostaglandin I(2).
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GO Term
GO:0001516 | prostaglandin biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring.
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GO Term
GO:0005019 | platelet-derived growth factor beta-receptor activity
Description: Combining with platelet-derived growth factor isoform PDGF-BB or PDGF-AB to initiate a change in cell activity.
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GO Term
GO:0048008 | platelet-derived growth factor receptor signaling pathway
Description: The series of molecular signals generated as a consequence of a platelet-derived growth factor receptor binding to one of its physiological ligands.
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GO Term
GO:0005018 | platelet-derived growth factor alpha-receptor activity
Description: Combining with platelet-derived growth factor isoform PDGF-AA, PDGF-BB or PDGF-AB to initiate a change in cell activity.
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GO Term
GO:0003912 | DNA nucleotidylexotransferase activity
Description: Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1).
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GO Term
GO:0019187 | beta-1,4-mannosyltransferase activity
Description: Catalysis of the transfer of a mannose residue to an oligosaccharide, forming a beta-(1->4) linkage.
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GO Term
GO:0005802 | trans-Golgi network
Description: The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination.
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GO Term
GO:0070681 | glutaminyl-tRNAGln biosynthesis via transamidation
Description: A tRNA aminoacylation process in which glutaminyl-tRNAGln is formed by a tRNA-dependent two-step pathway. In the first step a non-discriminating glutamyl-tRNAGlx synthetase generates the misacylated L-glutamyl-tRNAGln species, and in the second step it is amidated to the correctly charged L-glutaminyl-tRNAGln by a glutamyl-tRNAGln amidotransferase.
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GO Term
GO:0005055 | laminin receptor activity
Description: Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity.
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GO Term
GO:0006167 | AMP biosynthetic process
Description: The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate.
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GO Term
GO:0032865 | ERMES complex
Description: A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles. The complex is also associated with actively replicating mitochondrial DNA nucleoids, and may further coordinate mitochondrial genome replication and membrane growth.
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GO Term
GO:0045703 | ketoreductase activity
Description: Catalysis of the reduction of a ketone group to form the corresponding alcohol.
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GO Term
GO:0030497 | fatty acid elongation
Description: The elongation of a fatty acid chain by the sequential addition of two-carbon units.
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GO Term
GO:0000096 | sulfur amino acid metabolic process
Description: The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine.
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GO Term
GO:0015446 | ATPase-coupled arsenite transmembrane transporter activity
Description: Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + arsenite(in) = ADP + phosphate + arsenite(out).
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GO Term
GO:0071722 | detoxification of arsenic-containing substance
Description: Any process that reduces or removes the toxicity of compounds containing arsenic, including arsenates, arsenites, and arsenides. These include transport of such compounds away from sensitive areas and to compartments or complexes whose purpose is sequestration of arsenic or arsenic-containing compounds.
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GO Term
GO:0004502 | kynurenine 3-monooxygenase activity
Description: Catalysis of the reaction: L-kynurenine + H(+) + NADPH + O(2) = 3-hydroxy-L-kynurenine + H(2)O + NADP(+).
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