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Search results 2201 to 2300 out of 202262 for *

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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF14510 | ABC-transporter N-terminal
Description: This domain is found at the N-terminus of ABC-transporter proteins from fungi, plants to higher eukaryotes. It is predicted to be an intracellular domain [1, 2, 3].
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Ontology Term
PANTHER:PTHR23074:SF19 | KATANIN P60 ATPASE-CONTAINING SUBUNIT A1
 
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Ontology Term
Pfam:PF09336 | Vps4 C terminal oligomerisation domain
Description: This domain is found at the C terminal of ATPase proteins involved in vacuolar sorting. It forms an alpha helix structure and is required for oligomerisation [1].
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Ontology Term
PANTHER:PTHR10285 | URIDINE KINASE
 
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Ontology Term
PANTHER:PTHR22767 | N-TERMINAL ACETYLTRANSFERASE-RELATED
 
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Ontology Term
PANTHER:PTHR22767:SF2 | N(ALPHA)-ACETYLTRANSFERASE 15/16, ISOFORM A
 
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Ontology Term
Pfam:PF12569 | N-terminal acetyltransferase A, auxiliary subunit
Description: This entry represents N-terminal acetyltransferase A (NatA) auxiliary subunit (also known as NMDA receptor-regulated protein 1 [1]), which is a non-catalytic component of the NatA N-terminal acetyltransferase that catalyses acetylation of proteins beginning with Met-Ser, Met-Gly and Met-Ala. N-terminal acetylation plays a role in normal eukaryotic translation and processing, protecting against proteolytic degradation and protein turnover. NAT1 anchors ARD1 and NAT5 to the ribosome, and may present the N terminus of nascent polypeptides for acetylation [2-4].
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Ontology Term
PANTHER:PTHR11370 | DNA-REPAIR PROTEIN XRCC1
 
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Ontology Term
PANTHER:PTHR16684 | CENTROMERE PROTEIN C
 
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Ontology Term
Pfam:PF01344 | Kelch motif
Description: The kelch motif was initially discovered in Kelch (Swiss:Q04652). In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase [1] for which a structure has been solved [2]. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in Pfam:PF00064, Pfam:PF00400 and Pfam:PF00415.
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Ontology Term
Pfam:PF09405 | CASC3/Barentsz eIF4AIII binding
Description: This domain is found on CASC3 (cancer susceptibility candidate gene 3 protein) which is also known as Barentsz (Btz). CASC3 is a component of the EJC (exon junction complex) which is a complex that is involved in post-transcriptional regulation of mRNA in metazoa. The complex is formed by the association of four proteins (eIF4AIII, Barentsz, Mago, and Y14), mRNA, and ATP. This domain wraps around eIF4AIII and stacks against the 5' nucleotide [1][2].
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Ontology Term
Pfam:PF08911 | NUP50 (Nucleoporin 50 kDa)
Description: Nucleoporin 50 kDa (NUP50) acts as a cofactor for the importin-alpha:importin-beta heterodimer, which in turn allows for transportation of many nuclear-targeted proteins through nuclear pore complexes. The C terminus of NUP50 binds importin-beta through RAN-GTP, the N terminus binds the C terminus of importin-alpha, while a central domain binds importin-beta. NUP50:importin-alpha:importin-beta then binds cargo and can stimulate nuclear import. The N-terminal domain of NUP50 is also able to actively displace nuclear localisation signals from importin-alpha [1].
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Ontology Term
PANTHER:PTHR19876:SF2 | COATOMER SUBUNIT BETA'
 
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Ontology Term
Pfam:PF04053 | Coatomer WD associated region
Description: This region is composed of WD40 repeats.
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Ontology Term
Pfam:PF01740 | STAS domain
Description: The STAS (after Sulphate Transporter and AntiSigma factor antagonist) domain is found in the C terminal region of Sulphate transporters and bacterial antisigma factor antagonists. It has been suggested that this domain may have a general NTP binding function [2].
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Ontology Term
PANTHER:PTHR31307 | TRIHELIX TRANSCRIPTION FACTOR ASIL2
 
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Ontology Term
PANTHER:PTHR11472 | DNA REPAIR DEAD HELICASE RAD3/XP-D SUBFAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR11472:SF4 | PROTEIN RTEL1-TNFRSF6B
 
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Ontology Term
Pfam:PF06733 | DEAD_2
Description: This represents a conserved region within a number of RAD3-like DNA-binding helicases that are seemingly ubiquitous - members include proteins of eukaryotic, bacterial and archaeal origin. RAD3 is involved in nucleotide excision repair, and forms part of the transcription factor TFIIH in yeast [1].
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Ontology Term
Pfam:PF13307 | Helicase C-terminal domain
Description: This domain is found at the C-terminus of DEAD-box helicases.
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Ontology Term
Pfam:PF04782 | Protein of unknown function (DUF632)
Description: This plant protein may be a leucine zipper, but there is no experimental evidence for this.
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Ontology Term
PANTHER:PTHR23108 | METHYLTRANSFERASE-RELATED
 
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Ontology Term
PANTHER:PTHR23108:SF0 | METHYLTRANSFERASE-LIKE PROTEIN 22
 
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Ontology Term
PANTHER:PTHR12161 | IST1 FAMILY MEMBER
 
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Ontology Term
Pfam:PF03398 | Regulator of Vps4 activity in the MVB pathway
Description: ESCRT-I, -II, and -III are endosomal sorting complexes required for transporting proteins and carry out cargo sorting and vesicle formation in the multivesicular bodies, MVBs, pathway. These complexes are transiently recruited from the cytoplasm to the endosomal membrane where they bind transmembrane proteins previously marked for degradation by mono-ubiquitination. Assembly of ESCRT-III, a complex composed of at least four subunits (Vps2, Vps24, Vps20, Snf7), is intimately linked with MVB vesicle formation, its disassembly being an essential step in the MVB vesicle formation, a reaction that is carried out by Vps4, an AAA-type ATPase. The family Ist1 is a regulator of Vps4 activity; by interacting with Did2 and Vps4, Ist1 appears to regulate the recruitment and oligomerisation of Vps4. Together Ist1, Did2, and Vta1 form a network of interconnected regulatory proteins that modulate Vps4 activity, thereby regulating the flow of cargo through the MVB pathway [1].
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Ontology Term
PANTHER:PTHR23132 | D-ALANINE--D-ALANINE LIGASE
 
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Ontology Term
PANTHER:PTHR23132:SF0 | D-ALANINE-D-ALANINE LIGASE FAMILY
 
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Ontology Term
Pfam:PF01820 | D-ala D-ala ligase N-terminus
Description: This family represents the N-terminal region of the D-alanine--D-alanine ligase enzyme EC:6.3.2.4 which is thought to be involved in substrate binding [2]. D-Alanine is one of the central molecules of the cross-linking step of peptidoglycan assembly. There are three enzymes involved in the D-alanine branch of peptidoglycan biosynthesis: the pyridoxal phosphate-dependent D-alanine racemase (Alr), the ATP-dependent D-alanine:D-alanine ligase (Ddl), and the ATP-dependent D-alanine:D-alanine-adding enzyme (MurF) [3]. This domain is structurally related to the PreATP-grasp domain.
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Ontology Term
PANTHER:PTHR24115:SF0 | FI21273P1-RELATED
 
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Ontology Term
PANTHER:PTHR10768 | 60S RIBOSOMAL PROTEIN L37
 
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Ontology Term
Pfam:PF01907 | Ribosomal protein L37e
Description: This family includes ribosomal protein L37 from eukaryotes and archaebacteria. The family contains many conserved cysteines and histidines suggesting that this protein may bind to zinc.
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Ontology Term
PANTHER:PTHR18929 | PROTEIN DISULFIDE ISOMERASE
 
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Ontology Term
Pfam:PF13848 | Thioredoxin-like domain
Description: NULL
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Ontology Term
PANTHER:PTHR11886 | DYNEIN LIGHT CHAIN
 
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Ontology Term
PANTHER:PTHR11886:SF22 | DYNEIN LIGHT CHAIN TYPE 1-LIKE PROTEIN
 
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Ontology Term
PANTHER:PTHR10996 | 2-HYDROXYACID DEHYDROGENASE-RELATED
 
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Ontology Term
Pfam:PF00389 | D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain
Description: This family represents the largest portion of the catalytic domain of 2-hydroxyacid dehydrogenases as the NAD binding domain is inserted within the structural domain.
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Ontology Term
Pfam:PF02826 | D-isomer specific 2-hydroxyacid dehydrogenase, NAD binding domain
Description: This domain is inserted into the catalytic domain, the large dehydrogenase and D-lactate dehydrogenase families in SCOP. N-terminal portion of which is represented by family Pfam:PF00389.
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Ontology Term
Pfam:PF03244 | Photosystem I reaction centre subunit VI
Description: Photosystem I (PSI) is an integral membrane protein complex that uses light energy to mediate electron transfer from plastocyanin to ferredoxin.
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Ontology Term
PANTHER:PTHR10744 | 40S RIBOSOMAL PROTEIN S11 FAMILY MEMBER
 
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Ontology Term
Pfam:PF00366 | Ribosomal protein S17
Description: NULL
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Ontology Term
PANTHER:PTHR24015:SF130 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF12325 | TATA element modulatory factor 1 TATA binding
Description: This is the C-terminal conserved coiled coil region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes [1]. The proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMF1_TATA_bd is the most conserved part of the TMFs [2]. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal [3] and plant cells. The Rab6-binding domain appears to be the same region as this C-terminal family [3].
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Ontology Term
Pfam:PF12329 | TATA element modulatory factor 1 DNA binding
Description: This is the middle region of a family of TATA element modulatory factor 1 proteins conserved in eukaryotes that contains at its N-terminal section a number of leucine zippers that could potentially form coiled coil structures.[1]. The whole proteins bind to the TATA element of some RNA polymerase II promoters and repress their activity. by competing with the binding of TATA binding protein. TMFs are evolutionarily conserved golgins that bind Rab6, a ubiquitous ras-like GTP-binding Golgi protein, and contribute to Golgi organisation in animal [3] and plant [4] cells.
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Ontology Term
PANTHER:PTHR11654:SF58 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR10926 | CELL CYCLE CONTROL PROTEIN 50
 
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Ontology Term
PANTHER:PTHR10926:SF0 | CELL CYCLE CONTROL PROTEIN 50A
 
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Ontology Term
Pfam:PF03381 | LEM3 (ligand-effect modulator 3) family / CDC50 family
Description: Members of this family have been predicted to contain transmembrane helices. The family member LEM3 (Swiss:P42838) is a ligand-effect modulator, mutation of which increases glucocorticoid receptor activity in response to dexamethasone and also confers increased activity on other intracellular receptors including the progesterone, oestrogen and mineralocorticoid receptors. LEM3 is thought to affect a downstream step in the glucocorticoid receptor pathway. Factors that modulate ligand responsiveness are likely to contribute to the context-specific actions of the glucocorticoid receptor in mammalian cells [1]. The products of genes YNR048w (Swiss:P53740), YNL323w (Swiss:P42838) and YCR094w (Swiss:P25656) (CDC50) show redundancy of function and are involved in regulation of transcription via CDC39 [2]. CDC39 (also known as NOT1) is normally a negative regulator of transcription either by affecting the general RNA polymerase II machinery or by altering chromatin structure [4]. One function of CDC39 is to block activation of the mating response pathway in the absence of pheromone, and mutation causes arrest in G1 by activation of the pathway [3]. It may be that the cold-sensitive arrest in G1 noticed in CDC50 mutants [2] may be due to inactivation of CDC39. The effects of LEM3 on glucocorticoid receptor activity may also be due to effects on transcription via CDC39.
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Ontology Term
PANTHER:PTHR12553 | ZINC PHOSPHODIESTERASE ELAC PROTEIN 2
 
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Ontology Term
Pfam:PF12706 | Beta-lactamase superfamily domain
Description: This family is part of the beta-lactamase superfamily and is related to Pfam:PF00753.
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Ontology Term
Pfam:PF13691 | tRNase Z endonuclease
Description: This is family of tRNase Z enzymes, that are closely related structurally to the Lactamase_B family members. tRNase Z is the endonuclease that is involved in tRNA 3'-end maturation through removal of the 3'-trailer sequences from tRNA precursors. The fission yeast Schizosaccharomyces pombe contains two candidate tRNase Zs encoded by two essential genes. The first, Swiss:Q10155, is targeted to the nucleus and has an SV40 nuclear localisation signal at its N-terminus, consisting of four consecutive arginine and lysine residues between residues 208 and 211 (KKRK) that is critical for the NLS function. The second, Swiss:P87168, is targeted to the mitochondria, with an N-terminal mitochondrial targeting signal within the first 38 residues [1].
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Ontology Term
PANTHER:PTHR23426 | FERREDOXIN/ADRENODOXIN
 
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Ontology Term
PANTHER:PTHR13360 | ACTIVATING SIGNAL COINTEGRATOR 1 COMPLEX SUBUNIT 1
 
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Ontology Term
Pfam:PF10469 | AKAP7 2'5' RNA ligase-like domain
Description: AKAP7_NLS is the N-terminal domain of the cyclic AMP-dependent protein kinase A, PKA, anchor protein AKAP7. This protein anchors PKA for its role in regulating PKA-mediated gene transcription in both somatic cells and oocytes [1]. AKAP7_NLS carries the nuclear localisation signal (NLS) KKRKK, that indicates the cellular destiny of this anchor protein [2]. Binding to the regulatory subunits RI and RII of PKA is mediated via the family AKAP7_RIRII_bdg. at the C-terminus. This family represents a region that contains two 2'5' RNA ligase like domains Pfam:PF02834. Presumably this domain carried out some as yet unknown enzymatic function.
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Ontology Term
PANTHER:PTHR21514 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR24177 | CASKIN
 
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Ontology Term
PANTHER:PTHR24177:SF1 | PROTEIN C46H3.2, ISOFORM A
 
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Ontology Term
PANTHER:PTHR23076 | METALLOPROTEASE M41 FTSH
 
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Ontology Term
Pfam:PF01434 | Peptidase family M41
Description: NULL
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Ontology Term
Pfam:PF05172 | Nup53/35/40-type RNA recognition motif
Description: Members of this family belong to the nucleor pore complex, NPC, the only gateway between the nucleus and the cytoplasm. The NPC consists of several subcomplexes each one of which is made up of multiple copies of several individual Nup, Nic or Sec protein subunits. In yeast, this Nup or nucleoporin subunit is numbered Nup53, Nup40 in Schizo. pombe and in vertebrates as Nup35. This subunit forms part of the inner ring within the membrane and interacts directly with Nup-Ndc1, considered to be an anchor for the NPC in the pore membrane [1]. This region of the Nup is the RNA-recognition region [2].
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Ontology Term
PANTHER:PTHR23406 | MALIC ENZYME-RELATED
 
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Ontology Term
PANTHER:PTHR23406:SF2 | NAD-DEPENDENT MALIC ENZYME, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF00390 | Malic enzyme, N-terminal domain
Description: NULL
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Ontology Term
Pfam:PF03949 | Malic enzyme, NAD binding domain
Description: NULL
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Ontology Term
PANTHER:PTHR12891 | DNA REPAIR/TRANSCRIPTION PROTEIN MET18/MMS19
 
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Ontology Term
PANTHER:PTHR12891:SF0 | MMS19 NUCLEOTIDE EXCISION REPAIR PROTEIN HOMOLOG
 
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Ontology Term
Pfam:PF12460 | RNAPII transcription regulator C-terminal
Description: MMS19 is required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription [1]. This C-terminal domain, along with the N-terminal, MMS19_N, form part of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly [2]. This domain has a HEAT-like repeat structure [3].
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Ontology Term
Pfam:PF14500 | Dos2-interacting transcription regulator of RNA-Pol-II
Description: This domain, along with the C-terminal part, Pfam:PF12460 [1], is an essential component of a silencing complex in fission yeast that contains Dos2, Rik1, Mms19 and Cdc20 (the catalytic subunit of DNA polymerase-epsilon). This complex regulates RNA polymerase II (RNA Pol II) activity in heterochromatin and is required for DNA replication and heterochromatin assembly [2].
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Ontology Term
Pfam:PF02668 | Taurine catabolism dioxygenase TauD, TfdA family
Description: This family consists of taurine catabolism dioxygenases of the TauD, TfdA family. TauD from E. coli Swiss:P37610 is a alpha-ketoglutarate-dependent taurine dioxygenase [1]. This enzyme catalyses the oxygenolytic release of sulfite from taurine [1]. TfdA from Burkholderia sp. Swiss:Q45423 is a 2,4-dichlorophenoxyacetic acid/alpha-ketoglutarate dioxygenase [2]. TfdA from Alcaligenes eutrophus JMP134 Swiss:P10088 is a 2,4-dichlorophenoxyacetate monooxygenase [3]. Also included are gamma-Butyrobetaine hydroxylase enzymes EC:1.14.11.1 [4].
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Ontology Term
PANTHER:PTHR24420:SF272 | CHITIN ELICITOR RECEPTOR KINASE 1
 
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Ontology Term
PANTHER:PTHR11851:SF49 | MITOCHONDRIAL-PROCESSING PEPTIDASE SUBUNIT ALPHA
 
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Ontology Term
PANTHER:PTHR32472 | DNA REPAIR PROTEIN RADA
 
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Ontology Term
Pfam:PF13481 | AAA domain
Description: This AAA domain is found in a wide variety of presumed DNA repair proteins.
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Ontology Term
Pfam:PF13541 | Subunit ChlI of Mg-chelatase
Description: NULL
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Ontology Term
PANTHER:PTHR31342 | PROTEIN CHUP1, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF01546 | Peptidase family M20/M25/M40
Description: This family includes a range of zinc metallopeptidases belonging to several families in the peptidase classification [1]. Family M20 are Glutamate carboxypeptidases. Peptidase family M25 contains X-His dipeptidases.
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Ontology Term
PANTHER:PTHR32212 | CYCLIN-LIKE F-BOX
 
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Ontology Term
PANTHER:PTHR10476 | CHARGED MULTIVESICULAR BODY PROTEIN
 
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Ontology Term
PANTHER:PTHR10476:SF2 | CHARGED MULTIVESICULAR BODY PROTEIN 1B
 
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Ontology Term
Pfam:PF03357 | Snf7
Description: This family of proteins are involved in protein sorting and transport from the endosome to the vacuole/lysosome in eukaryotic cells. Vacuoles/lysosomes play an important role in the degradation of both lipids and cellular proteins. In order to perform this degradative function, vacuoles/lysosomes contain numerous hydrolases which have been transported in the form of inactive precursors via the biosynthetic pathway and are proteolytically activated upon delivery to the vacuole/lysosome. The delivery of transmembrane proteins, such as activated cell surface receptors to the lumen of the vacuole/lysosome, either for degradation/downregulation, or in the case of hydrolases, for proper localisation, requires the formation of multivesicular bodies (MVBs). These late endosomal structures are formed by invaginating and budding of the limiting membrane into the lumen of the compartment. During this process, a subset of the endosomal membrane proteins is sorted into the forming vesicles. Mature MVBs fuse with the vacuole/lysosome, thereby releasing cargo containing vesicles into its hydrolytic lumen for degradation. Endosomal proteins that are not sorted into the intralumenal MVB vesicles are either recycled back to the plasma membrane or Golgi complex, or remain in the limiting membrane of the MVB and are thereby transported to the limiting membrane of the vacuole/lysosome as a consequence of fusion. Therefore, the MVB sorting pathway plays a critical role in the decision between recycling and degradation of membrane proteins [1]. A few archaeal sequences are also present within this family.
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Ontology Term
PANTHER:PTHR10544 | 60S RIBOSOMAL PROTEIN L28
 
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Ontology Term
PANTHER:PTHR10544:SF0 | 60S RIBOSOMAL PROTEIN L28
 
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Ontology Term
Pfam:PF01778 | Ribosomal L28e protein family
Description: NULL
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Ontology Term
PANTHER:PTHR11871 | PROTEIN PHOSPHATASE PP2A REGULATORY SUBUNIT B
 
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Ontology Term
Pfam:PF04718 | Mitochondrial ATP synthase g subunit
Description: The Fo sector of the ATP synthase is a membrane bound complex which mediates proton transport. It is composed of nine different polypeptide subunits (a, b, c, d, e, f, g F6, A6L). The function of subunit g is currently unknown. The conserved region covers all but the very N-terminus of the member sequences. No prokaryotic members have been identified thus far [1].
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Ontology Term
PANTHER:PTHR20889 | PHOSPHATASE, ORPHAN 1, 2
 
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Ontology Term
Pfam:PF06888 | Putative Phosphatase
Description: This family contains a number of putative eukaryotic acid phosphatases. Some family members represent the products of the PSI14 phosphatase family in Lycopersicon esculentum (Tomato) [1].
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Ontology Term
PANTHER:PTHR20889:SF0 | INORGANIC PYROPHOSPHATASE 1-RELATED
 
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Ontology Term
PANTHER:PTHR22850 | WD40 REPEAT FAMILY
 
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Ontology Term
Pfam:PF05879 | Root hair defective 3 GTP-binding protein (RHD3) GTPase domain
Description: This is the GTPase domain of several eukaryotic root hair defective 3 (RHD3) like GTP-binding proteins, including RHD3 from Arabidopsis and Sey1 from yeast [1,2,3], which are involved in homotypic membrane fusion of the endoplasmic reticulum [3]. This domain binds GTP and forms dimers with other molecule for membrane tethering [3].
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Ontology Term
PANTHER:PTHR11552 | GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE
 
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Ontology Term
PANTHER:PTHR24420:SF443 | PROTEIN KINASE FAMILY PROTEIN
 
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Ontology Term
PANTHER:PTHR12459 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR24075 | SEC63 DOMAIN-CONTAINING
 
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Ontology Term
Pfam:PF02889 | Sec63 Brl domain
Description: This domain (also known as the Brl domain) is required for assembly of functional endoplasmic reticulum translocons [2].
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Ontology Term
PANTHER:PTHR22970 | AT-RICH INTERACTIVE DOMAIN-CONTAINING PROTEIN 2
 
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Ontology Term
PANTHER:PTHR11685 | RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING
 
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Ontology Term
Pfam:PF00097 | Zinc finger, C3HC4 type (RING finger)
Description: The C3HC4 type zinc-finger (RING finger) is a cysteine-rich domain of 40 to 60 residues that coordinates two zinc ions, and has the consensus sequence: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C where X is any amino acid [1]. Many proteins containing a RING finger play a key role in the ubiquitination pathway [2].
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Ontology Term
Pfam:PF01485 | IBR domain, a half RING-finger domain
Description: The IBR (In Between Ring fingers) domain is often found to occur between pairs of ring fingers (Pfam:PF00097). This domain has also been called the C6HC domain and DRIL (for double RING finger linked) domain [2]. Proteins that contain two Ring fingers and an IBR domain (these proteins are also termed RBR family proteins) are thought to exist in all eukaryotic organisms. RBR family members play roles in protein quality control and can indirectly regulate transcription [3]. Evidence suggests that RBR proteins are often parts of cullin-containing ubiquitin ligase complexes. The ubiquitin ligase Parkin is an RBR family protein whose mutations are involved in forms of familial Parkinson's disease [3][4].
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Ontology Term
PANTHER:PTHR12765 | RED PROTEIN IK FACTOR CYTOKINE IK
 
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USDA
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