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Search results 1901 to 2000 out of 202262 for *

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Categories

Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF04032 | RNAse P Rpr2/Rpp21/SNM1 subunit domain
Description: This family contains a ribonuclease P subunit of humans and yeast. Other members of the family include the probable archaeal homologues. This family includes SNM1 [2]. It is a subunit of RNase MRP (mitochondrial RNA processing), a ribonucleoprotein endoribonuclease that has roles in both mitochondrial DNA replication and nuclear 5.8S rRNA processing. SNM1 is an RNA binding protein that binds the MRP RNA specifically [2]. This subunit possibly binds the precursor tRNA [1].
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Ontology Term
PANTHER:PTHR12505 | PHD FINGER TRANSCRIPTION FACTOR
 
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Ontology Term
Pfam:PF07500 | Transcription factor S-II (TFIIS), central domain
Description: Transcription elongation by RNA polymerase II is regulated by the general elongation factor TFIIS. This factor stimulates RNA polymerase II to transcribe through regions of DNA that promote the formation of stalled ternary complexes. TFIIS is composed of three structural domains, termed I, II, and III. The two C-terminal domains (II and III), this domain and Pfam:PF01096 are required for transcription activity [1].
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Ontology Term
PANTHER:PTHR12174 | SIGNAL PEPTIDE PEPTIDASE
 
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Ontology Term
PANTHER:PTHR24361:SF1 | SERINE/THREONINE-PROTEIN KINASE BCK1/SLK1/SSP31
 
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Ontology Term
PANTHER:PTHR31798 | HYDROXYPROLINE-RICH GLYCOPROTEIN-LIKE
 
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Ontology Term
PANTHER:PTHR31319:SF1 | ZINC FINGER PROTEIN CONSTANS-RELATED
 
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Ontology Term
PANTHER:PTHR31152 | PLAC8 FAMILY PROTEIN
 
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Ontology Term
PANTHER:PTHR23029 | PHOSPHOGLYCERATE MUTASE
 
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Ontology Term
Pfam:PF00300 | Histidine phosphatase superfamily (branch 1)
Description: The histidine phosphatase superfamily is so named because catalysis centres on a conserved His residue that is transiently phosphorylated during the catalytic cycle. Other conserved residues contribute to a 'phosphate pocket' and interact with the phospho group of substrate before, during and after its transfer to the His residue. Structure and sequence analyses show that different families contribute different additional residues to the 'phosphate pocket' and, more surprisingly, differ in the position, in sequence and in three dimensions, of a catalytically essential acidic residue. The superfamily may be divided into two main branches. The larger branch 1 contains a wide variety of catalytic functions, the best known being fructose 2,6-bisphosphatase (found in a bifunctional protein with 2-phosphofructokinase) and cofactor-dependent phosphoglycerate mutase. The latter is an unusual example of a mutase activity in the superfamily: the vast majority of members appear to be phosphatases. The bacterial regulatory protein phosphatase SixA is also in branch 1 and has a minimal, and possible ancestral-like structure, lacking the large domain insertions that contribute to binding of small molecules in branch 1 members.
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Ontology Term
Pfam:PF12680 | SnoaL-like domain
Description: This family contains a large number of proteins that share the SnoaL fold.
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Ontology Term
PANTHER:PTHR24055:SF10 | MITOGEN-ACTIVATED PROTEIN KINASE 14A-RELATED
 
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Ontology Term
PANTHER:PTHR12146 | 40S RIBOSOMAL PROTEIN S10
 
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Ontology Term
PANTHER:PTHR12146:SF0 | S10_PLECTIN DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF03501 | Plectin/S10 domain
Description: This presumed domain is found at the N-terminus of some isoforms of the cytoskeletal muscle protein plectin as well as the ribosomal S10 protein. This domain may be involved in RNA binding.
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Ontology Term
PANTHER:PTHR32125 | 2-C-METHYL-D-ERYTHRITOL 4-PHOSPHATE CYTIDYLYLTRANSFERASE, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF02542 | YgbB family
Description: The ygbB protein is a putative enzyme of deoxy-xylulose pathway (terpenoid biosynthesis) [1].
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Ontology Term
PANTHER:PTHR10848 | MEIOTIC RECOMBINATION PROTEIN SPO11
 
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Ontology Term
PANTHER:PTHR22904:SF10 | PROTEIN SGT1 HOMOLOG A-RELATED
 
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Ontology Term
Pfam:PF04969 | CS domain
Description: The CS and CHORD (Pfam:PF04968) are fused into a single polypeptide chain in metazoans but are found in separate proteins in plants; this is thought to be indicative of an interaction between CS and CHORD [1]. It has been suggested that the CS domain is a binding module for HSP90, implying that CS domain-containing proteins are involved in recruiting heat shock proteins to multiprotein assemblies [2]. Two CS domains are found at the N-terminus of Ubiquitin carboxyl-terminal hydrolase 19 (USP19) (Swiss:O94966), these domains may play a role in the interaction of USP19 with cellular inhibitor of apoptosis 2 [3].
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Ontology Term
Pfam:PF05002 | SGS domain
Description: This domain was thought to be unique to the SGT1-like proteins [1], but is also found in calcyclin binding proteins.
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Ontology Term
PANTHER:PTHR10782 | ZINC FINGER MIZ DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR10782:SF4 | TONALLI, ISOFORM E
 
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Ontology Term
Pfam:PF02891 | MIZ/SP-RING zinc finger
Description: This domain has SUMO (small ubiquitin-like modifier) ligase activity and is involved in DNA repair and chromosome organisation [2][3].
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Ontology Term
PANTHER:PTHR31087 | FAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR31827 | EMB|CAB89363.1
 
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Ontology Term
PANTHER:PTHR12608 | TRANSMEMBRANE PROTEIN HTP-1 RELATED
 
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Ontology Term
Pfam:PF01169 | Uncharacterized protein family UPF0016
Description: This family contains integral membrane proteins of unknown function. Most members of the family contain two copies of a region that contains an EXGD motif. Each of these regions contains three predicted transmembrane regions. It has been suggested that these proteins are calcium transporters [1].
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Ontology Term
PANTHER:PTHR31071 | GB|AAF24581.1
 
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Ontology Term
PANTHER:PTHR11214 | BETA-1,3-N-ACETYLGLUCOSAMINYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR11214:SF7 | BETA-1,3-GALACTOSYLTRANSFERASE 11-RELATED
 
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Ontology Term
Pfam:PF01762 | Galactosyltransferase
Description: This family includes the galactosyltransferases UDP-galactose:2-acetamido-2-deoxy-D-glucose3beta-galactosyltransferas e Swiss:O43825 [1] and UDP-Gal:beta-GlcNAc beta 1,3-galactosyltranferase Swiss:O54904 [2]. Specific galactosyltransferases transfer galactose to GlcNAc terminal chains in the synthesis of the lacto-series oligosaccharides types 1 and 2 [1].
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Ontology Term
Pfam:PF13334 | Domain of unknown function (DUF4094)
Description: This domain is found in plant proteins that often carry a galactosyltransferase domain, Pfam:PF01762, at their C-terminus.
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Ontology Term
PANTHER:PTHR11246 | PRE-MRNA SPLICING FACTOR
 
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Ontology Term
PANTHER:PTHR11246:SF3 | CROOKED NECK-LIKE PROTEIN 1
 
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Ontology Term
Pfam:PF02184 | HAT (Half-A-TPR) repeat
Description: The HAT (Half A TPR) repeat is found in several RNA processing proteins [1].
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Ontology Term
PANTHER:PTHR11024 | NUCLEAR PORE COMPLEX PROTEIN SEC13 / SEH1 FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR31657 | ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF061
 
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Ontology Term
PANTHER:PTHR31657:SF0 | ETHYLENE-RESPONSIVE TRANSCRIPTION FACTOR ERF055-RELATED
 
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Ontology Term
PANTHER:PTHR24096 | LONG-CHAIN-FATTY-ACID--COA LIGASE
 
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Ontology Term
PANTHER:PTHR24096:SF46 | LONG-CHAIN-FATTY-ACID--COA LIGASE 1
 
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Ontology Term
Pfam:PF00501 | AMP-binding enzyme
Description: NULL
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Ontology Term
PANTHER:PTHR13513 | E3 UBIQUITIN-PROTEIN LIGASE UBR7
 
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Ontology Term
PANTHER:PTHR13513:SF9 | E3 UBIQUITIN-PROTEIN LIGASE UBR7-RELATED
 
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Ontology Term
PANTHER:PTHR10366:SF39 | UDP-GLUCOSE 4-EPIMERASE
 
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Ontology Term
PANTHER:PTHR11566 | DYNAMIN
 
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Ontology Term
PANTHER:PTHR11566:SF12 | DYNAMIN-LIKE 120 KDA PROTEIN, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF00350 | Dynamin family
Description: NULL
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Ontology Term
Pfam:PF01031 | Dynamin central region
Description: This is the stalk region which lies between the GTPase domain, see Pfam:PF00350, and the pleckstrin homology (PH) domain, see Pfam:PF00169. This region dimerises in a cross-like fashion forming a dynamin dimer in which the two G-domains are oriented in opposite directions [1].
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Ontology Term
Pfam:PF02212 | Dynamin GTPase effector domain
Description: NULL
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Ontology Term
PANTHER:PTHR31479 | ALPHA/BETA-HYDROLASES SUPERFAMILY PROTEIN
 
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Ontology Term
PANTHER:PTHR10666 | UBIQUITIN
 
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Ontology Term
PANTHER:PTHR12953 | MEMBRANE PROTEIN CH1 RELATED
 
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Ontology Term
PANTHER:PTHR12953:SF0 | SUN DOMAIN-CONTAINING OSSIFICATION FACTOR
 
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Ontology Term
Pfam:PF07738 | Sad1 / UNC-like C-terminal
Description: The C. elegans UNC-84 protein is a nuclear envelope protein that is involved in nuclear anchoring and migration during development. The S. pombe Sad1 protein localises at the spindle pole body. UNC-84 and and Sad1 share a common C-terminal region, that is often termed the SUN (Sad1 and UNC) domain [1-2]. In mammals, the SUN domain is present in two proteins, Sun1 and Sun2 [1]. The SUN domain of Sun2 has been demonstrated to be in the periplasm [2].
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Ontology Term
PANTHER:PTHR24290 | FAMILY NOT NAMED
 
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Ontology Term
Pfam:PF01078 | Magnesium chelatase, subunit ChlI
Description: Magnesium-chelatase is a three-component enzyme that catalyses the insertion of Mg2+ into protoporphyrin IX. This is the first unique step in the synthesis of (bacterio)chlorophyll. Due to this, it is thought that Mg-chelatase has an important role in channelling inter- mediates into the (bacterio)chlorophyll branch in response to conditions suitable for photosynthetic growth. ChlI and BchD have molecular weight between 38-42 kDa.
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Ontology Term
PANTHER:PTHR13452 | THUMP DOMAIN CONTAINING PROTEIN 1-RELATED
 
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Ontology Term
Pfam:PF02926 | THUMP domain
Description: The THUMP domain is named after after thiouridine synthases, methylases and PSUSs [1]. The THUMP domain consists of about 110 amino acid residues. The structure of ThiI reveals that the THUMP has a fold unlike that of previously characterised RNA-binding domains [2]. It is predicted that this domain is an RNA-binding domain The THUMP domain probably functions by delivering a variety of RNA modification enzymes to their targets [1].
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Ontology Term
PANTHER:PTHR19443 | HEXOKINASE
 
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Ontology Term
Pfam:PF03727 | Hexokinase
Description: Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF00349. Some members of the family have two copies of each of these domains.
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Ontology Term
PANTHER:PTHR19443:SF0 | HEXOKINASE A, ISOFORM A-RELATED
 
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Ontology Term
Pfam:PF00349 | Hexokinase
Description: Hexokinase (EC:2.7.1.1) contains two structurally similar domains represented by this family and Pfam:PF03727. Some members of the family have two copies of each of these domains.
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Ontology Term
PANTHER:PTHR11134 | ADAPTOR COMPLEX SUBUNIT BETA FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR11134:SF3 | AP COMPLEX SUBUNIT BETA
 
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Ontology Term
Pfam:PF02883 | Adaptin C-terminal domain
Description: Alpha adaptin is a heterotetramer which regulates clathrin-bud formation. The carboxyl-terminal appendage of the alpha subunit regulates translocation of endocytic accessory proteins to the bud site. This ig-fold domain is found in alpha, beta and gamma adaptins.
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Ontology Term
Pfam:PF09066 | Beta2-adaptin appendage, C-terminal sub-domain
Description: Members of this family adopt a structure consisting of a 5 stranded beta-sheet, flanked by one alpha helix on the outer side, and by two alpha helices on the inner side. This domain is required for binding to clathrin, and its subsequent polymerisation. Furthermore, a hydrophobic patch present in the domain also binds to a subset of D-phi-F/W motif-containing proteins that are bound by the alpha-adaptin appendage domain (epsin, AP180, eps15) [1].
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Ontology Term
PANTHER:PTHR22904:SF145 | TETRATRICOPEPTIDE REPEAT-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR24009 | RNA-BINDING (RRM/RBD/RNP MOTIFS)
 
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Ontology Term
PANTHER:PTHR24009:SF0 | ZINC FINGER (CCCH-TYPE) FAMILY PROTEIN / RNA RECOGNITION MOTIF (RRM)-CONTAINING PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR23139 | RNA-BINDING PROTEIN
 
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Ontology Term
PANTHER:PTHR11557 | PORPHOBILINOGEN DEAMINASE
 
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Ontology Term
PANTHER:PTHR11557:SF0 | PORPHOBILINOGEN DEAMINASE
 
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Ontology Term
Pfam:PF01379 | Porphobilinogen deaminase, dipyromethane cofactor binding domain
Description: NULL
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Ontology Term
Pfam:PF03900 | Porphobilinogen deaminase, C-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR11097 | EXOSOME COMPLEX EXONUCLEASE RIBOSOMAL RNA PROCESSING PROTEIN
 
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Ontology Term
PANTHER:PTHR11097:SF8 | EXOSOME COMPLEX COMPONENT RRP42
 
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Ontology Term
Pfam:PF03725 | 3' exoribonuclease family, domain 2
Description: This family includes 3'-5' exoribonucleases. Ribonuclease PH contains a single copy of this domain, and removes nucleotide residues following the -CCA terminus of tRNA. Polyribonucleotide nucleotidyltransferase (PNPase) contains two tandem copies of the domain. PNPase is involved in mRNA degradation in a 3'-5' direction. The exosome is a 3'-5' exoribonuclease complex that is required for 3' processing of the 5.8S rRNA. Three of its five protein components, Swiss:P46948 Swiss:Q12277 and Swiss:P25359 contain a copy of this domain [1]. Swiss:Q10205, a hypothetical protein from S. pombe appears to belong to an uncharacterised subfamily. This subfamily is found in both eukaryotes and archaebacteria.
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Ontology Term
PANTHER:PTHR24322:SF31 | DEHYDROGENASE/REDUCTASE SDR FAMILY MEMBER 7
 
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Ontology Term
PANTHER:PTHR12548 | TRANSCRIPTION FACTOR DP
 
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Ontology Term
Pfam:PF02319 | E2F/DP family winged-helix DNA-binding domain
Description: This family contains the transcription factor E2F and its dimerisation partners TDP1 and TDP2, which stimulate E2F-dependent transcription. E2F binds to DNA as a homodimer or as a heterodimer in association with TDP1/2, the heterodimer having increased binding efficiency. The crystal structure of an E2F4-DP2-DNA complex shows that the DNA-binding domains of the E2F and DP proteins both have a fold related to the winged-helix DNA-binding motif. Recognition of the central c/gGCGCg/c sequence of the consensus DNA-binding site is symmetric, and amino acids that contact these bases are conserved among all known E2F and DP proteins.
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Ontology Term
Pfam:PF08781 | Transcription factor DP
Description: DP forms a heterodimer with E2F and regulates genes involved in cell cycle progression. The transcriptional activity of E2F is inhibited by the retinoblastoma protein which binds to the E2F-DP heterodimer [2] and negatively regulates the G1-S transition.
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Ontology Term
PANTHER:PTHR14270 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR12477 | SYNOVIOLIN-RELATED
 
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Ontology Term
Pfam:PF00195 | Chalcone and stilbene synthases, N-terminal domain
Description: The C-terminal domain of Chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in this N-terminal domain.
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Ontology Term
Pfam:PF02797 | Chalcone and stilbene synthases, C-terminal domain
Description: This domain of chalcone synthase is reported to be structurally similar to domains in thiolase and beta-ketoacyl synthase. The differences in activity are accounted for by differences in the N-terminal domain.
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Ontology Term
PANTHER:PTHR11223 | EXPORTIN 1/5
 
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Ontology Term
Pfam:PF03810 | Importin-beta N-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR17204 | PRE-MRNA PROCESSING PROTEIN PRP39-RELATED
 
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Ontology Term
PANTHER:PTHR21262 | GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE
 
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Ontology Term
Pfam:PF13328 | HD domain
Description: HD domains are metal dependent phosphohydrolases.
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Ontology Term
Pfam:PF04607 | Region found in RelA / SpoT proteins
Description: This region of unknown function is found in RelA and SpoT of Escherichia coli, and their homologues in plants and in other eubacteria. RelA is a guanosine 3',5'-bis-pyrophosphate (ppGpp) synthetase (EC:2.7.6.5) while SpoT is thought to be a bifunctional enzyme catalysing both ppGpp synthesis and degradation (ppGpp 3'-pyrophosphohydrolase, (EC:3.1.7.2)) [1]. This region is often found in association with HD (Pfam:PF01966), a metal-dependent phosphohydrolase, TGS (Pfam:PF02824) which is a possible nucleotide-binding region, and the ACT regulatory domain (Pfam:PF01842).
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Ontology Term
PANTHER:PTHR13348 | RIBONUCLEASE P SUBUNIT P29
 
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Ontology Term
Pfam:PF01868 | Ribonuclease P/MRP, subunit p29
Description: This family consists of several archaeal and eukaryotic proteins. The archaeal proteins are found to be expressed within ribosomal operons and several of the sequences are described as ribonuclease P protein subunit p29 proteins [1,2]. The structure of the RNase P subunit, Rpp29, from Methanobacterium thermoautotrophicum has been determined. Mth Rpp29 is a member of the oligonucleotide/oligosaccharide binding fold family. It contains a structured beta-barrel core and unstructured N- and C-terminal extensions bearing several highly conserved amino acid residues that could be involved in RNA contacts in the protein-RNA complex [2]. Rpp29 catalyses the endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor. It interacts with the Rpp25 and Pop5 subunits.
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Ontology Term
PANTHER:PTHR24031:SF25 | ATP-DEPENDENT RNA HELICASE DDX46-RELATED
 
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Ontology Term
PANTHER:PTHR14212 | U4/U6-ASSOCIATED RNA SPLICING FACTOR-RELATED
 
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Ontology Term
PANTHER:PTHR14212:SF0 | U4/U6 SMALL NUCLEAR RIBONUCLEOPROTEIN PRP3
 
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Ontology Term
Pfam:PF06544 | Protein of unknown function (DUF1115)
Description: This family represents the C-terminus of hypothetical eukaryotic proteins of unknown function.
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Ontology Term
Pfam:PF08572 | pre-mRNA processing factor 3 (PRP3)
Description: Pre-mRNA processing factor 3 (PRP3) is a U4/U6-associated splicing factor. The human PRP3 has been implicated in autosomal retinitis pigmentosa [2].
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Ontology Term
Pfam:PF02434 | Fringe-like
Description: The drosophila protein fringe (FNG) is a glucosaminyltransferase that controls the response of the Notch receptor to specific ligands [1]. FNG is localised to the Golgi apparatus [1] (not secreted as previously thought). Modification of Notch occurs through glycosylation by FNG. The xenopus homologue, lunatic fringe, has been implicated in a variety of functions.
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