Search our database by keyword

- or -

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, pathways, authors, ontology terms, etc. (e.g. eve, embryo, zen, allele)
  • Use OR to search for either of two terms (e.g. fly OR drosophila) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. dros* for partial matches or fly AND NOT embryo to exclude a term

Search results 2401 to 2500 out of 202262 for *

Category restricted to OntologyTerm (x)

<< First    < Previous  |  Next >    Last >>
0.041s

Categories

Category: OntologyTerm
« show all
Type Details Score
Ontology Term
PANTHER:PTHR12537:SF12 | MATERNAL PROTEIN PUMILIO
 
•
•
•
•
•
Ontology Term
Pfam:PF00806 | Pumilio-family RNA binding repeat
Description: Puf repeats (aka PUM-HD, Pumilio homology domain) are necessary and sufficient for sequence specific RNA binding in fly Pumilio and worm FBF-1 and FBF-2. Both proteins function as translational repressors in early embryonic development by binding sequences in the 3' UTR of target mRNAs (e.g. the nanos response element (NRE) in fly Hunchback mRNA, or the point mutation element (PME) in worm fem-3 mRNA). Other proteins that contain Puf domains are also plausible RNA binding proteins. Swiss:P47135, for instance, appears to also contain a single RRM domain by HMM analysis. Puf domains usually occur as a tandem repeat of 8 domains. The Pfam model does not necessarily recognise all 8 repeats in all sequences; some sequences appear to have 5 or 6 repeats on initial analysis, but further analysis suggests the presence of additional divergent repeats. Structures of PUF repeat proteins show they consist of a two helix structure [3,4].
•
•
•
•
•
Ontology Term
PANTHER:PTHR11977 | VILLIN
 
•
•
•
•
•
Ontology Term
Pfam:PF00626 | Gelsolin repeat
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF02209 | Villin headpiece domain
Description: NULL
•
•
•
•
•
Ontology Term
PANTHER:PTHR11178 | IRON-SULFUR CLUSTER SCAFFOLD PROTEIN NFU-RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF01106 | NifU-like domain
Description: This is an alignment of the carboxy-terminal domain. This is the only common region between the NifU protein from nitrogen-fixing bacteria and rhodobacterial species. The biochemical function of NifU is unknown [1].
•
•
•
•
•
Ontology Term
Pfam:PF00152 | tRNA synthetases class II (D, K and N)
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF13426 | PAS domain
Description: This domain is found in many signalling proteins in which it functions as a sensor domain. It recognises FMN, Zn(II), FAD and riboflavin (MAtilla et. al., FEMS Microbiology Reviews, fuab043, 45, 2021, 1. https://doi.org/10.1093/femsre/fuab043).
•
•
•
•
•
Ontology Term
PANTHER:PTHR24420:SF527 | ADENINE NUCLEOTIDE ALPHA HYDROLASES-DOMAIN CONTAINING PROTEIN KINASE-RELATED
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR30615 | UNCHARACTERIZED PROTEIN YJBQ-RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF01894 | Uncharacterised protein family UPF0047
Description: This family has no known function. The alignment contains a conserved aspartate and histidine that may be functionally important.
•
•
•
•
•
Ontology Term
PANTHER:PTHR13321 | MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION, SUBUNIT 18
 
•
•
•
•
•
Ontology Term
Pfam:PF01218 | Coproporphyrinogen III oxidase
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF06480 | FtsH Extracellular
Description: This domain is found in the FtsH family of proteins. FtsH is the only membrane-bound ATP-dependent protease universally conserved in prokaryotes ([1]). It only efficiently degrades proteins that have a low thermodynamic stability - e.g. it lacks robust unfoldase activity. This feature may be key and implies that this could be a criterion for degrading a protein. In Oenococcus oeni FtsH is involved in protection against environmental stress ([2]), and shows increased expression under heat or osmotic stress. These two lines of evidence suggest that it is a fundamental prokaryotic self-protection mechanism that checks if proteins are correctly folded (personal obs: Yeats C). The precise function of this N-terminal region is unclear.
•
•
•
•
•
Ontology Term
PANTHER:PTHR10497 | 60S RIBOSOMAL PROTEIN L27
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR10497:SF0 | 60S RIBOSOMAL PROTEIN L27
 
•
•
•
•
•
Ontology Term
Pfam:PF01777 | Ribosomal L27e protein family
Description: The N-terminal region of the eukaryotic ribosomal L27 has the KOW motif. C-terminal region is represented by this family.
•
•
•
•
•
Ontology Term
PANTHER:PTHR24198 | ANKYRIN REPEAT AND PROTEIN KINASE DOMAIN-CONTAINING PROTEIN
 
•
•
•
•
•
Ontology Term
Pfam:PF12298 | Eukaryotic mitochondrial regulator protein
Description: This family of proteins is found in eukaryotes. Proteins in this family are typically between 168 and 381 amino acids in length. Bot1p localizes to the mitochondria in live cells and cofractionates with purified mitochondrial ribosomes. Bot1p has a novel function in the control of cell respiration by acting on the mitochondrial protein synthesis machinery. Observations also indicate that in fission yeast, alterations of mitochondrial function are linked to changes in cell cycle and cell morphology control mechanisms.
•
•
•
•
•
Ontology Term
PANTHER:PTHR12176 | SAM-DEPENDENT METHYLTRANSFERASE SUPERFAMILY PROTEIN
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR10739 | CYTIDYLYLTRANSFERASE
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR10739:SF13 | GH25855P-RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF01467 | Cytidylyltransferase-like
Description: This family includes: Cholinephosphate cytidylyltransferase Swiss:P49585; glycerol-3-phosphate cytidylyltransferase Swiss:P27623. It also includes putative adenylyltransferases, and FAD synthases.
•
•
•
•
•
Ontology Term
PANTHER:PTHR32494 | ALLANTOATE DEIMINASE-RELATED
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR32382 | FASCICLIN-LIKE ARABINOGALACTAN PROTEIN
 
•
•
•
•
•
Ontology Term
Pfam:PF02469 | Fasciclin domain
Description: This extracellular domain is found repeated four times in grasshopper fasciclin I as well as in proteins from mammals, sea urchins, plants, yeast and bacteria [1].
•
•
•
•
•
Ontology Term
PANTHER:PTHR21461 | UNCHARACTERIZED
 
•
•
•
•
•
Ontology Term
Pfam:PF01697 | Glycosyltransferase family 92
Description: Members of this family act as galactosyltransferases, belonging to glycosyltransferase family 92 [1,2,3]. The aligned region contains several conserved cysteine residues and several charged residues that may be catalytic residues. This is supported by the inclusion of this family in the GT-A glycosyl transferase superfamily.
•
•
•
•
•
Ontology Term
PANTHER:PTHR31376 | OS09G0467300 PROTEIN-RELATED
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR11630 | DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR11630:SF43 | DNA REPLICATION LICENSING FACTOR MCM6
 
•
•
•
•
•
Ontology Term
Pfam:PF00493 | MCM P-loop domain
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF14551 | MCM N-terminal domain
Description: This family contains the N-terminal domain of MCM proteins.
•
•
•
•
•
Ontology Term
PANTHER:PTHR22683 | SPORULATION PROTEIN RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF05558 | DREPP plasma membrane polypeptide
Description: This family contains several plant plasma membrane proteins termed DREPPs as they are developmentally regulated plasma membrane polypeptides [1].
•
•
•
•
•
Ontology Term
PANTHER:PTHR23336 | ZINC FINGER CW-TYPE COILED-COIL DOMAIN PROTEIN 3.
 
•
•
•
•
•
Ontology Term
Pfam:PF07496 | CW-type Zinc Finger
Description: This domain appears to be a zinc finger. The alignment shows four conserved cysteine residues and a conserved tryptophan. It was first identified by [1], and is predicted to be a "highly specialised mononuclear four-cysteine zinc finger...that plays a role in DNA binding and/or promoting protein-protein interactions in complicated eukaryotic processes including ...chromatin methylation status and early embryonic development." Weak homology to Pfam:PF00628 further evidences these predictions (personal obs: C Yeats). Twelve different CW-domain-containing protein subfamilies are described, with different subfamilies being characteristic of vertebrates, higher plants and other animals in which these domain is found [1].
•
•
•
•
•
Ontology Term
PANTHER:PTHR11932 | CULLIN
 
•
•
•
•
•
Ontology Term
Pfam:PF00888 | Cullin family
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF10557 | Cullin protein neddylation domain
Description: This is the neddylation site of cullin proteins which are a family of structurally related proteins containing an evolutionarily conserved cullin domain. With the exception of APC2, each member of the cullin family is modified by Nedd8 and several cullins function in Ubiquitin-dependent proteolysis, a process in which the 26S proteasome recognises and subsequently degrades a target protein tagged with K48-linked poly-ubiquitin chains. Cullins are molecular scaffolds responsible for assembling the ROC1/Rbx1 RING-based E3 ubiquitin ligases, of which several play a direct role in tumorigenesis. Nedd8/Rub1 is a small ubiquitin-like protein, which was originally found to be conjugated to Cdc53, a cullin component of the SCF (Skp1-Cdc53/CUL1-F-box protein) E3 Ub ligase complex in Saccharomyces cerevisiae, and Nedd8 modification has now emerged as a regulatory pathway of fundamental importance for cell cycle control and for embryogenesis in metazoans. The only identified Nedd8 substrates are cullins. Neddylation results in covalent conjugation of a Nedd8 moiety onto a conserved cullin lysine residue [1].
•
•
•
•
•
Ontology Term
PANTHER:PTHR24089:SF59 | MITOCHONDRIAL THIAMINE PYROPHOSPHATE CARRIER
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR10442 | 40S RIBOSOMAL PROTEIN S21
 
•
•
•
•
•
Ontology Term
Pfam:PF01249 | Ribosomal protein S21e
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF03073 | TspO/MBR family
Description: Tryptophan-rich sensory protein (TspO) is an integral membrane protein that acts as a negative regulator of the expression of specific photosynthesis genes in response to oxygen/light [1]. It is involved in the efflux of porphyrin intermediates from the cell. This reduces the activity of coproporphyrinogen III oxidase, which is thought to lead to the accumulation of a putative repressor molecule that inhibits the expression of specific photosynthesis genes. Several conserved aromatic residues are necessary for TspO function: they are thought to be involved in binding porphyrin intermediates [3]. In [2], the rat mitochondrial peripheral benzodiazepine receptor (MBR) was shown to not only retain its structure within a bacterial outer membrane, but also to be able to functionally substitute for TspO in TspO- mutants, and to act in a similar manner to TspO in its in situ location: the outer mitochondrial membrane. The biological significance of MBR remains unclear, however. It is thought to be involved in a variety of cellular functions, including cholesterol transport in steroidogenic tissues.
•
•
•
•
•
Ontology Term
PANTHER:PTHR31311 | XYLOGLUCAN 6-XYLOSYLTRANSFERASE 5-RELATED-RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF05637 | galactosyl transferase GMA12/MNN10 family
Description: This family contains a number of glycosyltransferase enzymes that contain a DXD motif. This family includes a number of C. elegans homologues where the DXD is replaced by DXH. Some members of this family are included in glycosyltransferase family 34.
•
•
•
•
•
Ontology Term
PANTHER:PTHR11006 | PROTEIN ARGININE N-METHYLTRANSFERASE
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR11006:SF10 | HISTONE-ARGININE METHYLTRANSFERASE CARMER-RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF05185 | PRMT5 arginine-N-methyltransferase
Description: The human homologue of yeast Skb1 (Shk1 kinase-binding protein 1) is PRMT5, an arginine-N-methyltransferase [3][4]. These proteins appear to be key mitotic regulators. They play a role in Jak signalling in higher eukaryotes.
•
•
•
•
•
Ontology Term
PANTHER:PTHR21567 | CLASP
 
•
•
•
•
•
Ontology Term
Pfam:PF12348 | CLASP N terminal
Description: This region is found at the N terminal of CLIP-associated proteins (CLASPs). CLASPs are widely conserved microtubule plus-end-tracking proteins that regulate the stability of dynamic microtubules [1][2]. In yeast, Drosophila, and Xenopus, a single CLASP orthologue is present. In mammals, a second paralogue (CLASP2) exists which has some functional overlap with CLASP1 [2].
•
•
•
•
•
Ontology Term
Pfam:PF02902 | Ulp1 protease family, C-terminal catalytic domain
Description: This domain contains the catalytic triad Cys-His-Asn.
•
•
•
•
•
Ontology Term
PANTHER:PTHR14222 | CONDENSIN
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR11991 | TRANSLATIONALLY CONTROLLED TUMOR PROTEIN-RELATED
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR11991:SF0 | TRANSLATIONALLY-CONTROLLED TUMOR PROTEIN
 
•
•
•
•
•
Ontology Term
Pfam:PF00838 | Translationally controlled tumour protein
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF12717 | non-SMC mitotic condensation complex subunit 1
Description: The three non-SMC (structural maintenance of chromosomes) subunits of the mitotic condensation complex are Cnd1-3. The whole complex is essential for viability and the condensing of chromosomes in mitosis.
•
•
•
•
•
Ontology Term
Pfam:PF09320 | Domain of unknown function (DUF1977)
Description: Members of this family of functionally uncharacterised domains are predominantly found in dnaj-like proteins.
•
•
•
•
•
Ontology Term
PANTHER:PTHR19923 | WD40 REPEAT PROTEINPRL1/PRL2-RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF01190 | Pollen protein Ole e 1 like
Description: NULL
•
•
•
•
•
Ontology Term
PANTHER:PTHR10791 | RAG1-ACTIVATING PROTEIN 1
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR10791:SF6 | MEDIATOR OF RNA POLYMERASE II TRANSCRIPTION SUBUNIT 13
 
•
•
•
•
•
Ontology Term
Pfam:PF03083 | Sugar efflux transporter for intercellular exchange
Description: This family includes proteins such as drosophila saliva [1], MtN3 involved in root nodule development [3] and a protein involved in activation and expression of recombination activation genes (RAGs) [2]. Although the molecular function of these proteins is unknown, they are almost certainly transmembrane proteins. This family contains a region of two transmembrane helices that is found in two copies in most members of the family. This family also contains specific sugar efflux transporters that are essential for the maintenance of animal blood glucose levels, plant nectar production, and plant seed and pollen development. In many organisims it meditaes gluose transport; in Arabidopsis it is necessary for pollen viability; and two of the rice homologues are specifically exploited by bacterial pathogens for virulence by means of direct binding of a bacterial effector to the SWEET promoter [4].
•
•
•
•
•
Ontology Term
PANTHER:PTHR22774 | UNCHARACTERIZED
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR13803 | SEC24-RELATED PROTEIN
 
•
•
•
•
•
Ontology Term
Pfam:PF08033 | Sec23/Sec24 beta-sandwich domain
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF00441 | Acyl-CoA dehydrogenase, C-terminal domain
Description: C-terminal domain of Acyl-CoA dehydrogenase is an all-alpha, four helical up-and-down bundle.
•
•
•
•
•
Ontology Term
Pfam:PF02770 | Acyl-CoA dehydrogenase, middle domain
Description: Central domain of Acyl-CoA dehydrogenase has a beta-barrel fold.
•
•
•
•
•
Ontology Term
Pfam:PF02771 | Acyl-CoA dehydrogenase, N-terminal domain
Description: The N-terminal domain of Acyl-CoA dehydrogenase is an all-alpha domain.
•
•
•
•
•
Ontology Term
Pfam:PF00787 | PX domain
Description: PX domains bind to phosphoinositides.
•
•
•
•
•
Ontology Term
PANTHER:PTHR21493 | CGI-141-RELATED/LIPASE CONTAINING PROTEIN
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR21493:SF2 | LIPASE CLASS 3 FAMILY PROTEIN
 
•
•
•
•
•
Ontology Term
Pfam:PF03893 | Lipase 3 N-terminal region
Description: N terminal region to Pfam:PF01764, found on a subset of Lipase 3 containing proteins.
•
•
•
•
•
Ontology Term
PANTHER:PTHR11736 | MELANOMA-ASSOCIATED ANTIGEN MAGE ANTIGEN
 
•
•
•
•
•
Ontology Term
Pfam:PF01454 | MAGE homology domain
Description: The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex [2-3]. Nse3 has been demonstrated to be important for meiosis[3].
•
•
•
•
•
Ontology Term
Pfam:PF00407 | Pathogenesis-related protein Bet v 1 family
Description: This family is named after Bet v 1, the major birch pollen allergen. This protein belongs to family 10 of plant pathogenesis-related proteins (PR-10), cytoplasmic proteins of 15-17 kd that are wide-spread among dicotyledonous plants [1]. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified. A classification by sequence similarity yielded several subfamilies related to PR-10 [2]: - Pathogenesis-related proteins PR-10: These proteins were identified as major tree pollen allergens in birch and related species (hazel, alder), as plant food allergens expressed in high levels in fruits, vegetables and seeds (apple, celery, hazelnut), and as pathogenesis-related proteins whose expression is induced by pathogen infection, wounding, or abiotic stress. Hyp-1 (Swiss:Q8H1L1), an enzyme involved in the synthesis of the bioactive naphthodianthrone hypericin in St. John's wort (Hypericum perforatum) also belongs to this family. Most of these proteins were found in dicotyledonous plants. In addition, related sequences were identified in monocots and conifers. - Cytokinin-specific binding proteins: These legume proteins bind cytokinin plant hormones [3]. - (S)-Norcoclaurine synthases are enzymes catalysing the condensation of dopamine and 4-hydroxyphenylacetaldehyde to (S)-norcoclaurine, the first committed step in the biosynthesis of benzylisoquinoline alkaloids such as morphine [4]. -Major latex proteins and ripening-related proteins are proteins of unknown biological function that were first discovered in the latex of opium poppy (Papaver somniferum) and later found to be upregulated during ripening of fruits such as strawberry and cucumber [4]. The occurrence of Bet v 1-related proteins is confined to seed plants with the exception of a cytokinin-binding protein from the moss Physcomitrella patens (Swiss:Q9AXI3).
•
•
•
•
•
Ontology Term
PANTHER:PTHR31343 | T15D22.8
 
•
•
•
•
•
Ontology Term
Pfam:PF05623 | Protein of unknown function (DUF789)
Description: This family consists of several plant proteins of unknown function.
•
•
•
•
•
Ontology Term
PANTHER:PTHR31875 | PROTEIN DEHYDRATION-INDUCED 19
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR31875:SF0 | PROTEIN DEHYDRATION-INDUCED 19-RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF14571 | Stress-induced protein Di19, C-terminal
Description: C-terminal domain of Di19, a protein that increases the sensitivity of plants to environmental stress, such as salinity, drought, osmotic stress and cold. the protein is also induced by an increased supply of stress-related hormones such as abscisic acid ABA and ethylene [1]. There is a zinc-finger at the N-terminus, zf-Di19, Pfam:PF05605.
•
•
•
•
•
Ontology Term
Pfam:PF04667 | cAMP-regulated phosphoprotein/endosulfine conserved region
Description: Conserved region found in both cAMP-regulated phosphoprotein 19 (ARPP-19) and Alpha/Beta endosulfine. No function has yet been assigned to ARPP-19. Endosulfine is the endogenous ligand for the ATP-dependent potassium (K ATP) channels which occupy a key position in the control of insulin release from the pancreatic beta cell by coupling cell polarity to metabolism. In both cases the region occupies the majority of the protein [1,2].
•
•
•
•
•
Ontology Term
PANTHER:PTHR30620 | PERIPLASMIC BETA-GLUCOSIDASE-RELATED
 
•
•
•
•
•
Ontology Term
Pfam:PF00933 | Glycosyl hydrolase family 3 N terminal domain
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF01915 | Glycosyl hydrolase family 3 C-terminal domain
Description: This domain is involved in catalysis and may be involved in binding beta-glucan [1]. This domain is found associated with Pfam:PF00933.
•
•
•
•
•
Ontology Term
Pfam:PF14310 | Fibronectin type III-like domain
Description: This domain has a fibronectin type III-like structure [1]. It is often found in association with Pfam:PF00933 and Pfam:PF01915. Its function is unknown.
•
•
•
•
•
Ontology Term
PANTHER:PTHR23335 | CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR CAMTA
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR23335:SF0 | CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR, ISOFORM F
 
•
•
•
•
•
Ontology Term
Pfam:PF03859 | CG-1 domain
Description: CG-1 domains are highly conserved domains of about 130 amino-acid residues containing a predicted bipartite NLS and named after a partial cDNA clone isolated from parsley encoding a sequence-specific DNA-binding protein [1]. CG-1 domains are associated with CAMTA proteins (for CAlModulin -binding Transcription Activator) that are transcription factors containing a calmodulin -binding domain and ankyrins (ANK) motifs [2].
•
•
•
•
•
Ontology Term
PANTHER:PTHR12884 | 60S RIBOSOMAL PROTEIN L29
 
•
•
•
•
•
Ontology Term
Pfam:PF01779 | Ribosomal L29e protein family
Description: NULL
•
•
•
•
•
Ontology Term
Pfam:PF02852 | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Description: This family includes both class I and class II oxidoreductases and also NADH oxidases and peroxidases.
•
•
•
•
•
Ontology Term
PANTHER:PTHR23318 | ATP SYNTHASE GAMMA-RELATED
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR23318:SF0 | SERINE/THREONINE-PROTEIN PHOSPHATASE 4 REGULATORY SUBUNIT 3
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR15371 | TIM23
 
•
•
•
•
•
Ontology Term
PANTHER:PTHR15371:SF0 | MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM23
 
•
•
•
•
•
Ontology Term
Pfam:PF02466 | Tim17/Tim22/Tim23/Pmp24 family
Description: The pre-protein translocase of the mitochondrial outer membrane (Tom) allows the import of pre-proteins from the cytoplasm. Tom forms a complex with a number of proteins, including Tim17 [1, 2, 3]. Tim17, Tim22, and Tim23, are the central components of the widely conserved multi-subunit protein translocases, TIM23 and TIM22, which mediate protein transport across and into the inner mitochondrial membrane, respectively [4]. In addition, several Tim17 family proteins occupy the inner and outer membranes of plastids. This family also includes Pmp24 a peroxisomal protein. The involvement of this domain in the targeting of PMP24 remains to be proved. PMP24 was known as Pmp27 [3]. Family members are suggested to be exclusive to eukaryotes, where the distribution in the eukaryotic subgroups of the mitochondrial Tim17, Tim22 and Tim23 proteins, as well as the peroxisomal Tim17 family proteins, suggests that they all likely to be present in the last eukaryotic common ancestor (LECA) [4].
•
•
•
•
•
Ontology Term
PANTHER:PTHR11239 | DNA-DIRECTED RNA POLYMERASE
 
•
•
•
•
•
Ontology Term
Pfam:PF01096 | Transcription factor S-II (TFIIS)
Description: NULL
•
•
•
•
•
USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom