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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF03137 | Organic Anion Transporter Polypeptide (OATP) family
Description: This family consists of several eukaryotic Organic-Anion-Transporting Polypeptides (OATPs). Several have been identified mostly in human and rat. Different OATPs vary in tissue distribution and substrate specificity. Since the numbering of different OATPs in particular species was based originally on the order of discovery, similarly numbered OATPs in humans and rats did not necessarily correspond in function, tissue distribution and substrate specificity (in spite of the name, some OATPs also transport organic cations and neutral molecules). Thus, Tamai et al. [1] initiated the current scheme of using digits for rat OATPs and letters for human ones. Prostaglandin transporter (PGT) proteins (e.g. Swiss:Q92959) are also considered to be OATP family members. In addition, the methotrexate transporter OATK (Swiss:P70502) is closely related to OATPs. This family also includes several predicted proteins from Caenorhabditis elegans and Drosophila melanogaster. This similarity was not previously noted. Note: Members of this family are described (in the Swiss-Prot database) as belonging to the SLC21 family of transporters.
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Ontology Term
PANTHER:PTHR11732:SF8 | PROTEIN MEC-14
 
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Ontology Term
PANTHER:PTHR10835 | SQUALENE MONOOXYGENASE
 
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Ontology Term
PANTHER:PTHR10835:SF0 | SQUALENE MONOOXYGENASE
 
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Ontology Term
Pfam:PF01946 | Thi4 family
Description: This family includes Swiss:P32318 a putative thiamine biosynthetic enzyme.
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Ontology Term
Pfam:PF08491 | Squalene epoxidase
Description: This domain is found in squalene epoxidase (SE) and related proteins which are found in taxonomically diverse groups of eukaryotes and also in bacteria. SE was first cloned from Saccharomyces cerevisiae where it was named ERG1. It contains a putative FAD binding site and is a key enzyme in the sterol biosynthetic pathway [1]. Putative transmembrane regions are found to the protein's C-terminus.
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Ontology Term
PANTHER:PTHR12064 | METAL TRANSPORTER CNNM
 
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Ontology Term
Pfam:PF01595 | Cyclin M transmembrane N-terminal domain
Description: This transmembrane domain is found in metal transporter proteins such as cyclin M 1/2 (CNNM). CNNMs are integral membrane proteins that are conserved from bacteria to humans. CNNM family members influence metal ion homeostasis through mechanisms that may not involve direct membrane transport of the ions. Structurally, CNNMs are complex proteins that contain an extracellular N-terminal domain preceding a transmembrane domain, a 'Bateman module', which consists of two cystathionine- beta-synthase (CBS) domains Pfam:PF00571, and a C-terminal cNMP (cyclic nucleotide monophosphate) binding domain [1, 2, 3, 4]. This entry describes the CNNM transmembrane domain which contains four hydrophobic regions and forms a dimer through hydrophobic contacts between TM2 and TM3, in which each chain is composed of three transmembrane helices (TM1-3), a pair of short helices exposed on the intracellular side, and a juxtamembrane (JM) helix that forms a belt-like structure [2,5]. The homodimer adopts an inward-facing conformation with a negatively charged cavity containing a conserved pi-helical turn in TM3 that coordinates a Mg2 ion [5].
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Ontology Term
Pfam:PF02679 | (2R)-phospho-3-sulfolactate synthase (ComA)
Description: In methanobacteria (2R)-phospho-3-sulfolactate synthase (ComA) catalyses the first step of the biosynthesis of coenzyme M from phosphoenolpyruvate (P-enolpyruvate). This novel enzyme catalyses the stereospecific Michael addition of sulfite to P-enolpyruvate, forming L-2-phospho-3-sulfolactate (PSL). It is suggested that the ComA-catalysed reaction is analogous to those reactions catalysed by beta-elimination enzymes that proceed through an enolate intermediate [1].
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Ontology Term
Pfam:PF11326 | Protein of unknown function (DUF3128)
Description: This eukaryotic family of proteins has no known function.
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Ontology Term
Pfam:PF01363 | FYVE zinc finger
Description: The FYVE zinc finger is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1. The FYVE finger has been shown to bind two Zn++ ions [1]. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. We have included members which do not conserve these histidine residues but are clearly related.
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Ontology Term
PANTHER:PTHR31225 | OS04G0344100 PROTEIN-RELATED
 
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Ontology Term
Pfam:PF01397 | Terpene synthase, N-terminal domain
Description: It has been suggested that this gene family be designated tps (for terpene synthase) [1]. It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.
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Ontology Term
Pfam:PF03936 | Terpene synthase family, metal binding domain
Description: It has been suggested that this gene family be designated tps (for terpene synthase) [1]. It has been split into six subgroups on the basis of phylogeny, called tpsa-tpsf. tpsa includes vetispiridiene synthase Swiss:Q39979, 5-epi- aristolochene synthase, Swiss:Q40577 and (+)-delta-cadinene synthase Swiss:P93665. tpsb includes (-)-limonene synthase, Swiss:Q40322. tpsc includes kaurene synthase A, Swiss:O04408. tpsd includes taxadiene synthase, Swiss:Q41594, pinene synthase, Swiss:O24475 and myrcene synthase, Swiss:O24474. tpse includes kaurene synthase B. tpsf includes linalool synthase.
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Ontology Term
PANTHER:PTHR15907 | DUF614 FAMILY PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR15141 | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3
 
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Ontology Term
PANTHER:PTHR15141:SF14 | TRANSCRIPTION ELONGATION FACTOR B POLYPEPTIDE 3
 
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Ontology Term
Pfam:PF08711 | TFIIS helical bundle-like domain
Description: Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function [3]. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex [4]. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5 [5,6].
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Ontology Term
PANTHER:PTHR23125:SF17 | GRR1-LIKE PROTEIN 1-RELATED
 
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Ontology Term
PANTHER:PTHR22915 | NADH DEHYDROGENASE-RELATED
 
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Ontology Term
PANTHER:PTHR22915:SF4 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR13211 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR22749 | RIBOFLAVIN KINASE/FMN ADENYLYLTRANSFERASE
 
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Ontology Term
Pfam:PF01687 | Riboflavin kinase
Description: This family represents the C-terminal region of the bifunctional riboflavin biosynthesis protein known as RibC in Bacillus subtilis. The RibC protein from Bacillus subtilis has both flavokinase and flavin adenine dinucleotide synthetase (FAD-synthetase) activities. RibC plays an essential role in the flavin metabolism [1]. This domain is thought to have kinase activity [2].
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Ontology Term
PANTHER:PTHR13260 | ANAPHASE PROMOTING COMPLEX SUBUNIT 4 APC4
 
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Ontology Term
PANTHER:PTHR13260:SF0 | ANAPHASE-PROMOTING COMPLEX SUBUNIT 4
 
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Ontology Term
Pfam:PF12894 | Anaphase-promoting complex subunit 4 WD40 domain
Description: Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilise the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,
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Ontology Term
Pfam:PF12896 | Anaphase-promoting complex, cyclosome, subunit 4
Description: Apc4 is one of the larger of the subunits of the anaphase-promoting complex or cyclosome. This family represents the long domain downstream of the WD40 repeat/s that are present on the Apc4 subunits. The anaphase-promoting complex is a multiprotein subunit E3 ubiquitin ligase complex that controls segregation of chromosomes and exit from mitosis in eukaryotes [1,2]. Results in C.elegans show that the primary essential role of the spindle assembly checkpoint is not in the chromosome segregation process itself but rather in delaying anaphase onset until all chromosomes are properly attached to the spindle. the APC/C is likely to be required for all metaphase-to-anaphase transitions in a multicellular organism [3].
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Ontology Term
PANTHER:PTHR31713:SF1 | CALMODULIN BINDING PROTEIN-LIKE PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR12937 | VACUOLAR PROTEIN SORTING 28, ISOFORM 2 VPS28
 
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Ontology Term
PANTHER:PTHR12937:SF0 | VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 28 HOMOLOG
 
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Ontology Term
Pfam:PF03997 | VPS28 protein
Description: NULL
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Ontology Term
Pfam:PF02265 | S1/P1 Nuclease
Description: This family contains both S1 and P1 nucleases (EC:3.1.30.1) which cleave RNA and single stranded DNA with no base specificity.
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Ontology Term
PANTHER:PTHR10687 | SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN SCAMP
 
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Ontology Term
PANTHER:PTHR10687:SF2 | SECRETORY CARRIER-ASSOCIATED MEMBRANE PROTEIN
 
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Ontology Term
Pfam:PF04144 | SCAMP family
Description: In vertebrates, secretory carrier membrane proteins (SCAMPs) 1-3 constitute a family of putative membrane-trafficking proteins composed of cytoplasmic N-terminal sequences with NPF repeats, four central transmembrane regions (TMRs), and a cytoplasmic tail. SCAMPs probably function in endocytosis by recruiting EH-domain proteins to the N-terminal NPF repeats but may have additional functions mediated by their other sequences [1].
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Ontology Term
PANTHER:PTHR31210 | OS06G0731900 PROTEIN
 
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Ontology Term
Pfam:PF05212 | Protein of unknown function (DUF707)
Description: This family consists of several uncharacterised proteins from Arabidopsis thaliana.
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Ontology Term
PANTHER:PTHR13317 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR13317:SF4 | TRANSMEMBRANE ANTERIOR POSTERIOR TRANSFORMATION PROTEIN 1 HOMOLOG
 
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Ontology Term
Pfam:PF05346 | Eukaryotic membrane protein family
Description: This family is a family of eukaryotic membrane proteins. It was previously annotated as including a putative receptor for human cytomegalovirus gH [1] but this has has since been disputed [2]. Analysis of the mouse Tapt1 protein (transmembrane anterior posterior transformation 1) has shown it to be involved in patterning of the vertebrate axial skeleton.
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Ontology Term
PANTHER:PTHR19845 | KATANIN P80 SUBUNIT
 
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Ontology Term
PANTHER:PTHR19845:SF0 | KATANIN P80 WD40 REPEAT-CONTAINING SUBUNIT B1
 
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Ontology Term
PANTHER:PTHR11802:SF8 | SERINE CARBOXYPEPTIDASE-LIKE 20-RELATED
 
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Ontology Term
PANTHER:PTHR31008 | COP1-INTERACTING PROTEIN-RELATED
 
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Ontology Term
Pfam:PF13676 | TIR domain
Description: This is a family of Toll-like receptors.
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Ontology Term
PANTHER:PTHR11474 | TYROSINASE FAMILY MEMBER
 
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Ontology Term
Pfam:PF00264 | Common central domain of tyrosinase
Description: This family also contains polyphenol oxidases and some hemocyanins. Binds two copper ions via two sets of three histidines. This family is related to Pfam:PF00372.
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Ontology Term
Pfam:PF12142 | Polyphenol oxidase middle domain
Description: This domain family is found in bacteria and eukaryotes, and is approximately 50 amino acids in length, and the family is found in association with Pfam:PF00264. Most members are annotated as being polyphenol oxidases, and many are from plants or plastids. There is a conserved DWL sequence motif which gives the family its name.
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Ontology Term
Pfam:PF12143 | Protein of unknown function (DUF_B2219)
Description: This domain family is found in eukaryotes, and is typically between 138 and 152 amino acids in length. and the family is found in association with Pfam:PF00264. Many members are plant or plastid polyphenol oxidases, and there is a highly conserved sequence motif: KFDV, from which the name derives. This is the C-terminal domain of these oxidases.
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Ontology Term
PANTHER:PTHR12428 | OXA1
 
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Ontology Term
Pfam:PF02096 | 60Kd inner membrane protein
Description: NULL
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Ontology Term
PANTHER:PTHR13115 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR13115:SF8 | RNA POLYMERASE-ASSOCIATED PROTEIN RTF1 HOMOLOG
 
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Ontology Term
PANTHER:PTHR22100 | WINGS APART-LIKE PROTEIN HOMOLOG
 
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Ontology Term
Pfam:PF07814 | Wings apart-like protein regulation of heterochromatin
Description: This family contains sequences expressed in eukaryotic organisms bearing high similarity to the WAPL conserved region of D. melanogaster wings apart-like protein. This protein is involved in the regulation of heterochromatin structure [1]. hWAPL (Swiss:Q7Z5K2), the human homologue, is found to play a role in the development of cervical carcinogenesis, and is thought to have similar functions to Drosophila wapl protein [2]. Malfunction of the hWAPL pathway is thought to activate an apoptotic pathway that consequently leads to cell death [2].
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Ontology Term
PANTHER:PTHR13152 | TFIIH, POLYPEPTIDE 4
 
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Ontology Term
PANTHER:PTHR13152:SF0 | GENERAL TRANSCRIPTION FACTOR IIH SUBUNIT 4
 
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Ontology Term
PANTHER:PTHR11361:SF14 | DNA MISMATCH REPAIR PROTEIN MUTS, TYPE 2
 
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Ontology Term
Pfam:PF01713 | Smr domain
Description: This family includes the Smr (Small MutS Related) proteins, and the C-terminal region of the MutS2 protein. It has been suggested that this domain interacts with the MutS1 Swiss:P23909 protein in the case of Smr proteins and with the N-terminal MutS related region of MutS2 Swiss:P94545 [1]. This domain exhibits nicking endonuclease activity that might have a role in mismatch repair or genetic recombination. It shows no significant double strand cleavage or exonuclease activity [2]. The full-length Swiss:Q86UW6 also has the polynucleotide kinase activity.
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Ontology Term
PANTHER:PTHR10293:SF16 | GLUTAREDOXIN-RELATED PROTEIN 5, MITOCHONDRIAL
 
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Ontology Term
PANTHER:PTHR23078 | VESICULAR-FUSION PROTEIN NSF
 
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Ontology Term
Pfam:PF02933 | Cell division protein 48 (CDC48), domain 2
Description: This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the C-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate 185-residue recognition domain [1].
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Ontology Term
PANTHER:PTHR24015:SF46 | OS12G0181900 PROTEIN
 
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Ontology Term
PANTHER:PTHR21349 | 50S RIBOSOMAL PROTEIN L21
 
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Ontology Term
PANTHER:PTHR21349:SF0 | 39S RIBOSOMAL PROTEIN L21, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF00829 | Ribosomal prokaryotic L21 protein
Description: NULL
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Ontology Term
PANTHER:PTHR23257:SF81 | PROTEIN KINASE 6-LIKE PROTEIN
 
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Ontology Term
PANTHER:PTHR15696 | SMG-7 SUPPRESSOR WITH MORPHOLOGICAL EFFECT ON GENITALIA PROTEIN 7
 
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Ontology Term
PANTHER:PTHR15696:SF0 | TELOMERASE-BINDING PROTEIN EST1A
 
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Ontology Term
Pfam:PF10373 | Est1 DNA/RNA binding domain
Description: Est1 is a protein which recruits or activates telomerase at the site of polymerisation [1][2]. This is the DNA/RNA binding domain of EST1 [3][4].
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Ontology Term
Pfam:PF10374 | Telomerase activating protein Est1
Description: Est1 is a protein which recruits or activates telomerase at the site of polymerisation [1][2]. Structurally it resembles a TPR-like repeat.
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Ontology Term
Pfam:PF08576 | Eukaryotic protein of unknown function (DUF1764)
Description: This is a family of eukaryotic proteins of unknown function. This family contains many hypothetical proteins.
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Ontology Term
PANTHER:PTHR13303 | PREFOLDIN SUBUNIT 2
 
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Ontology Term
Pfam:PF01920 | Prefoldin subunit
Description: This family includes prefoldin subunits that are not detected by Pfam:PF02996.
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Ontology Term
Pfam:PF05605 | Drought induced 19 protein (Di19), zinc-binding
Description: This family consists of several drought induced 19 (Di19) like proteins. Di19 has been found to be strongly expressed in both the roots and leaves of Arabidopsis thaliana during progressive drought [1]. This domain is a zinc-binding domain.
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Ontology Term
PANTHER:PTHR31472 | OS05G0244600 PROTEIN
 
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Ontology Term
Pfam:PF02791 | DDT domain
Description: The DDT domain is named after (DNA binding homeobox and Different Transcription factors) and is approximately 60 residues in length [1]. Along with the WHIM motifs, it comprises an entirely alpha helical module found in diverse eukaryotic chromatin proteins [2]. Based on the structure of Ioc3, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [2][3]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes [2]. In particular, the DDT domain, in combination with the WHIM1 and WHIM2 motifs form the SLIDE domain binding pocket [2].
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Ontology Term
Pfam:PF05066 | HB1, ASXL, restriction endonuclease HTH domain
Description: A winged helix-turn-helix domain present in the plant HB1, vertebrate ASXL, the H. pylori restriction endonuclease HpyAIII(HgrA), the RNA polymerase delta subunit(RpoE) of Gram positive bacteria and several restriction endonucleases [1]. The domain is distinguished by the presence of a conserved one-turn helix between helix-3 and the preceding conserved turn. Its diverse architectures in eukaryotic species with extensive gene body methylation is suggestive of a chromatin function. The genetic interaction of the HARE-HTH containing ASXL with the methyl cytosine hydroxylating Tet2 protein is suggestive of a role for the domain in discriminating sequences with DNA modifications such as hmC [1]. Bacterial versions include fusions to diverse restriction endonucleases, and a DNA glycosylase where it may play a similar role in detecting modified DNA. Certain bacterial version of the HARE-HTH domain show fusions to the helix-hairpin-helix domain of the RNA polymerase alpha subunit and the HTH domains found in regions 3 and 4 of the sigma factors [1]. These versions are predicted to function as a novel inhibitor of the binding of RNA polymerase to transcription start sites, similar to the Bacillus delta protein [2,3].
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Ontology Term
Pfam:PF15612 | WSTF, HB1, Itc1p, MBD9 motif 1
Description: A conserved alpha helical motif that along with the WHIM2 and WHIM3 motifs, and the DDT domain comprise an alpha helical module found in diverse eukaryotic chromatin proteins [1].Based on the Ioc3 structure, this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [1][2]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes [2]. The conserved basic residue in WHIM1 is involved in packing with the DDT motif. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognising and DNA binding domains, some of which discriminate methylated DNA [1].
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Ontology Term
Pfam:PF15613 | Williams-Beuren syndrome DDT (WSD), D-TOX E motif
Description: This family represents the combined alpha-helical module found in diverse eukaryotic chromatin proteins [1]. Based on the Ioc3 structure, the N-terminus of this module is inferred to interact with nucleosomal linker DNA and the SLIDE domain of ISWI proteins [1,2]. The resulting complex forms a protein ruler that measures out the spacing between two adjacent nucleosomes [2]. The acidic residue from the GxD signature at the N-terminus is a major determinant of the interaction between the ISWI and WHIM motifs. The N-terminal portion also contacts the inter-nucleosomal linker DNA. The module shows a great domain architectural diversity and is often combined with other modified histone peptide recognizing and DNA binding domains, some of which discriminate methylated DNA. The WSD module constitutes the inter-nucleosomal linker DNA binding site in the major groove of DNA [1], and was first identified as WSD [3], the D-TOX E motif of plant homeodomains homologous with the mutant transcription factor causing Williams-Beuren syndrome in association with the DDT-domain.
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Ontology Term
PANTHER:PTHR31621 | PROTEIN DMP3
 
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Ontology Term
PANTHER:PTHR31621:SF0 | PROTEIN DMP6
 
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Ontology Term
Pfam:PF05078 | Protein of unknown function (DUF679)
Description: This family includes members such as plant proteins AtDMPs 1-10 (Arabidopsis thaliana DUF679 domain membrane proteins 1 -10) [1]. The AtDMP proteins are predicted to have four transmembrane spans, with cytosolic amino- and carboxy-termini. DMP1 is a membrane protein that may be involved in membrane fission during breakdown of the ER and the tonoplast during leaf senescence and in membrane fusion during vacuole biogenesis in roots [2]. Several DMP proteins are expressed in senescing organs (DMP1, -3, -4) or tissues that will stall later in development (DMP1, -2, -4, -7). These expression patterns strongly suggest involvement of several DMPs in various programmed cell death processes, e.g. senescence, dehiscence and abscission [1]. AtDMP8 and AtDMP9 however, have been shown to facilitate gamete fusion during double fertilisation in flowering plants [3].
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Ontology Term
PANTHER:PTHR31079 | NAC DOMAIN-CONTAINING PROTEIN 73
 
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Ontology Term
PANTHER:PTHR23308 | NUCLEAR INHIBITOR OF PROTEIN PHOSPHATASE-1
 
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Ontology Term
PANTHER:PTHR10751 | GUANYLATE BINDING PROTEIN
 
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Ontology Term
PANTHER:PTHR10751:SF2 | GB1/RHD3-TYPE G DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF02263 | Guanylate-binding protein, N-terminal domain
Description: Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.
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Ontology Term
Pfam:PF02841 | Guanylate-binding protein, C-terminal domain
Description: Transcription of the anti-viral guanylate-binding protein (GBP) is induced by interferon-gamma during macrophage induction. This family contains GBP1 and GPB2, both GTPases capable of binding GTP, GDP and GMP.
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Ontology Term
PANTHER:PTHR11746 | O-METHYLTRANSFERASE
 
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Ontology Term
Pfam:PF00891 | O-methyltransferase domain
Description: This family includes a range of O-methyltransferases. These enzymes utilise S-adenosyl methionine.
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Ontology Term
Pfam:PF08100 | Dimerisation domain
Description: This domain is found at the N-terminus of a variety of plant O-methyltransferases. It has been shown to mediate dimerisation of these proteins [1].
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Ontology Term
PANTHER:PTHR24073:SF87 | DRAB11
 
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Ontology Term
Pfam:PF05918 | Apoptosis inhibitory protein 5 (API5)
Description: This family consists of apoptosis inhibitory protein 5 (API5) sequences from several organisms. Apoptosis or programmed cell death is a physiological form of cell death that occurs in embryonic development and organ formation. It is characterised by biochemical and morphological changes such as DNA fragmentation and cell volume shrinkage. API5 is an anti apoptosis gene located in human chromosome 11, whose expression prevents the programmed cell death that occurs upon the deprivation of growth factors [1,2] and is up-regulated in various cancer cells. This protein has an elongated all alpha-helical structure, in which the N-terminal half is similar to the HEAT repeat and the C-terminal half is similar to the ARM (Armadillo-like) repeat. This suggests that API5 is involved in protein-protein interactions and may act as a scaffold for multiprotein complexes [3].
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Ontology Term
PANTHER:PTHR12992 | NUDIX HYDROLASE
 
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Ontology Term
PANTHER:PTHR10859 | GLYCOSYL TRANSFERASE
 
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Ontology Term
PANTHER:PTHR10859:SF37 | DOLICHOL-PHOSPHATE MANNOSYLTRANSFERASE
 
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Ontology Term
Pfam:PF00535 | Glycosyl transferase family 2
Description: Diverse family, transferring sugar from UDP-glucose, UDP-N-acetyl- galactosamine, GDP-mannose or CDP-abequose, to a range of substrates including cellulose, dolichol phosphate and teichoic acids.
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Ontology Term
PANTHER:PTHR13191 | RIBOSOMAL RNA PROCESSING PROTEIN 7-RELATED
 
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