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Search results 3701 to 3800 out of 202262 for *

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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF01493 | GXGXG motif
Description: This domain is found in glutamate synthase, tungsten formylmethanofuran dehydrogenase subunit c (FwdC) and molybdenum formylmethanofuran dehydrogenase subunit c (FmdC). A repeated G-XX-G-XXX-G motif is seen in the alignment.
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Ontology Term
Pfam:PF01645 | Conserved region in glutamate synthase
Description: This family represents a region of the glutamate synthase protein. This region is expressed as a separate subunit in the glutamate synthase alpha subunit from archaebacteria, or part of a large multidomain enzyme in other organisms. The aligned region of these proteins contains a putative FMN binding site and Fe-S cluster.
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Ontology Term
Pfam:PF11900 | Domain of unknown function (DUF3420)
Description: This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is about 50 amino acids in length. This domain is found associated with Pfam:PF00023.
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Ontology Term
PANTHER:PTHR11645 | PYRROLINE-5-CARBOXYLATE REDUCTASE
 
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Ontology Term
Pfam:PF03807 | NADP oxidoreductase coenzyme F420-dependent
Description: NULL
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Ontology Term
Pfam:PF14748 | Pyrroline-5-carboxylate reductase dimerisation
Description: Pyrroline-5-carboxylate reductase consists of two domains, an N-terminal catalytic domain (Pfam:PF03807) and a C-terminal dimerisation domain. This is the dimerisation domain [1].
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Ontology Term
PANTHER:PTHR10920 | RIBOSOMAL RNA METHYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR13247 | TETRATRICOPEPTIDE REPEAT PROTEIN 11 TPR REPEAT PROTEIN 11
 
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Ontology Term
PANTHER:PTHR13247:SF0 | MITOCHONDRIAL FISSION 1 PROTEIN
 
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Ontology Term
Pfam:PF14852 | Fis1 N-terminal tetratricopeptide repeat
Description: The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the N-terminal tetratricopeptide repeat [1-2]
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Ontology Term
Pfam:PF14853 | Fis1 C-terminal tetratricopeptide repeat
Description: The mitochondrial fission protein Fis1 consists of two tetratricopeptide repeats. This domain is the C-terminal tetratricopeptide repeat [1-2]
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Ontology Term
PANTHER:PTHR11808 | TRANS-SULFURATION ENZYME FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR11808:SF18 | CYSTATHIONINE BETA-LYASE
 
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Ontology Term
Pfam:PF01053 | Cys/Met metabolism PLP-dependent enzyme
Description: This family includes enzymes involved in cysteine and methionine metabolism. The following are members: Cystathionine gamma-lyase, Cystathionine gamma-synthase, Cystathionine beta-lyase, Methionine gamma-lyase, OAH/OAS sulfhydrylase, O-succinylhomoserine sulfhydrylase All of these members participate is slightly different reactions. All these enzymes use PLP (pyridoxal-5'-phosphate) as a cofactor.
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Ontology Term
Pfam:PF03088 | Strictosidine synthase
Description: Strictosidine synthase (E.C. 4.3.3.2) is a key enzyme in alkaloid biosynthesis. It catalyses the condensation of tryptamine with secologanin to form strictosidine.
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Ontology Term
Pfam:PF00175 | Oxidoreductase NAD-binding domain
Description: Xanthine dehydrogenases, that also bind FAD/NAD, have essentially no similarity.
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Ontology Term
PANTHER:PTHR13935 | ACHAETE-SCUTE TRANSCRIPTION FACTOR-RELATED
 
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Ontology Term
PANTHER:PTHR11711:SF67 | LIPASE 4-RELATED
 
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Ontology Term
Pfam:PF11815 | Domain of unknown function (DUF3336)
Description: This family of proteins are functionally uncharacterised. This family is found in bacteria and eukaryotes. This presumed domain is typically between 143 to 227 amino acids in length.
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Ontology Term
Pfam:PF07839 | Plant calmodulin-binding domain
Description: The sequences featured in this family are found repeated in a number of plant calmodulin-binding proteins (such as Swiss:Q8W235, Swiss:Q84ZT8 and Swiss:Q8H6X1), and are thought to constitute the calmodulin-binding domains [1,2]. Binding of the proteins to calmodulin depends on the presence of calcium ions [1,2]. These proteins are thought to be involved in various processes, such as plant defence responses [1] and stolonisation or tuberization [2].
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Ontology Term
Pfam:PF00194 | Eukaryotic-type carbonic anhydrase
Description: NULL
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Ontology Term
Pfam:PF02704 | Gibberellin regulated protein
Description: This is the GASA gibberellin regulated cysteine rich protein family. The expression of these proteins is up-regulated by the plant hormone gibberellin, most of these proteins have some role in plant development. There are 12 cysteine residues conserved within the alignment giving the potential for these proteins to posses 6 disulphide bonds.
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Ontology Term
PANTHER:PTHR21329 | PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q-RELATED
 
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Ontology Term
PANTHER:PTHR21329:SF3 | PHOSPHATIDYLINOSITOL N-ACETYLGLUCOSAMINYLTRANSFERASE SUBUNIT Q
 
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Ontology Term
Pfam:PF05024 | N-acetylglucosaminyl transferase component (Gpi1)
Description: Glycosylphosphatidylinositol (GPI) represents an important anchoring molecule for cell surface proteins.The first step in its synthesis is the transfer of N-acetylglucosamine (GlcNAc) from UDP-N-acetylglucosamine to phosphatidylinositol (PI). This chemically simple step is genetically complex because three or four genes are required in both yeast (GPI1, GPI2 and GPI3) and mammals (GPI1, PIG A, PIG H and PIG C), respectively [1].
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Ontology Term
PANTHER:PTHR11089 | GTP-BINDING PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR11089:SF3 | PROTEIN Y48E1B.2, ISOFORM A
 
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Ontology Term
PANTHER:PTHR23196 | PAX TRANSCRIPTION ACTIVATION DOMAIN INTERACTING PROTEIN
 
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Ontology Term
PANTHER:PTHR12668 | TRANSMEMBRANE PROTEIN 14, 15
 
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Ontology Term
Pfam:PF03647 | Transmembrane proteins 14C
Description: This family of short membrane proteins are as yet uncharacterised.
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Ontology Term
Pfam:PF09265 | Cytokinin dehydrogenase 1, FAD and cytokinin binding
Description: Members of this family adopt an alpha+beta sandwich structure with an antiparallel beta-sheet, in a ferredoxin-like fold. They are predominantly found in plant cytokinin dehydrogenase 1, where they are capable of binding both FAD and cytokinin substrates. The substrate displays a 'plug-into-socket' binding mode that seals the catalytic site and precisely positions the carbon atom undergoing oxidation in close contact with the reactive locus of the flavin [1].
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Ontology Term
Pfam:PF13181 | Tetratricopeptide repeat
Description: NULL
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Ontology Term
PANTHER:PTHR18952 | CARBONIC ANHYDRASE
 
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Ontology Term
PANTHER:PTHR10799:SF213 | DNA HELICASE INO80
 
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Ontology Term
Pfam:PF13892 | DNA-binding domain
Description: DBINO is a DNA-binding domain found on global transcription activator SNF2L1 proteins and chromatin re-modelling proteins.
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Ontology Term
PANTHER:PTHR11728 | GLYCEROL-3-PHOSPHATE DEHYDROGENASE
 
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Ontology Term
Pfam:PF01210 | NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus
Description: NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the N-terminal NAD-binding domain [2].
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Ontology Term
Pfam:PF07479 | NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus
Description: NAD-dependent glycerol-3-phosphate dehydrogenase (GPDH) catalyses the interconversion of dihydroxyacetone phosphate and L-glycerol-3-phosphate. This family represents the C-terminal substrate-binding domain [2].
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Ontology Term
Pfam:PF07498 | Rho termination factor, N-terminal domain
Description: The Rho termination factor disengages newly transcribed RNA from its DNA template at certain, specific transcripts. It it thought that two copies of Rho bind to RNA and that Rho functions as a hexamer of protomers [1]. This domain is found to the N-terminus of the RNA binding domain (Pfam:PF07497).
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Ontology Term
PANTHER:PTHR31879 | DET1- AND DDB1-ASSOCIATED PROTEIN 1
 
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Ontology Term
Pfam:PF10172 | Det1 complexing ubiquitin ligase
Description: DDA1 (De-etiolated 1, Damaged DNA binding protein 1 associated 1) protein binds strongly with DDB1 and Det1 forming a DDD complex which is part of the ubiquitin conjugation system [1].
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Ontology Term
PANTHER:PTHR20961:SF0 | GLYCOSYLTRANSFERASE-LIKE DOMAIN-CONTAINING PROTEIN 2
 
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Ontology Term
PANTHER:PTHR11089:SF4 | MITOCHONDRIAL GTPASE 1
 
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Ontology Term
PANTHER:PTHR11266 | PEROXISOMAL MEMBRANE PROTEIN 2, PXMP2 MPV17
 
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Ontology Term
Pfam:PF04117 | Mpv17 / PMP22 family
Description: The 22-kDa peroxisomal membrane protein (PMP22) is a major component of peroxisomal membranes. PMP22 seems to be involved in pore forming activity and may contribute to the unspecific permeability of the organelle membrane. PMP22 is synthesised on free cytosolic ribosomes and then directed to the peroxisome membrane by specific targeting information [1]. Mpv17 is a closely related peroxisomal protein. In mouse, the Mpv17 protein is involved in the development of early-onset glomerulosclerosis [2]. More recently a homolog of Mpv17 in S. cerevisiae has been been found to be an integral membrane protein of the inner mitochondrial membrane where it has been proposed to have a role in ethanol metabolism and tolerance during heat-shock [3]. Defects in MPV17 is associated with mitochondrial DNA depletion syndrome (MDDS) and Navajo neurohepatopathy (NNH) [4][5]. MDDS is a clinically heterogeneous group of disorders characterised by a reduction in mitochondrial DNA (mtDNA) copy number. Primary mtDNA depletion is inherited as an autosomal recessive trait and may affect single organs, typically muscle or liver, or multiple tissues. Individuals with the hepatocerebral form of mitochondrial DNA depletion syndrome have early progressive liver failure and neurologic abnormalities, hypoglycemia, and increased lactate in body fluids. NNH is an autosomal recessive disease that is prevalent among Navajo children in the South Western states of America. The major clinical features are hepatopathy, peripheral neuropathy, corneal anesthesia and scarring, acral mutilation, cerebral leukoencephalopathy, failure to thrive, and recurrent metabolic acidosis with intercurrent infections. Infantile, childhood, and classic forms of NNH have been described. Mitochondrial DNA depletion was detected in the livers of patients, suggesting a primary defect in mtDNA maintenance [5].
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Ontology Term
PANTHER:PTHR12151 | ELECTRON TRANSPORT PROTIN SCO1/SENC FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR12151:SF0 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF02630 | SCO1/SenC
Description: This family is involved in biogenesis of respiratory and photosynthetic systems. SCO1 (Swiss:P23833) is required for a post-translational step in the accumulation of subunits COXI and COXII of cytochrome c oxidase [1]. SenC (Swiss:Q52720) is required for optimal cytochrome c oxidase activity and maximal induction of genes encoding the light-harvesting and reaction centre complexes of R. capsulatus [2].
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Ontology Term
PANTHER:PTHR19229 | ATP-BINDING CASSETTE TRANSPORTER SUBFAMILY A ABCA
 
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Ontology Term
Pfam:PF12698 | ABC-2 family transporter protein
Description: This family is related to the ABC-2 membrane transporter family Pfam:PF01061 [1].
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Ontology Term
PANTHER:PTHR21392 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF03942 | DTW domain
Description: This presumed domain is found in bacterial and eukaryotic proteins. Its function is unknown. The domain contains multiple conserved motifs including a DTXW motif that this domain has been named after.
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Ontology Term
PANTHER:PTHR20882 | CYTOPLASMIC TRNA 2-THIOLATION PROTEIN 2
 
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Ontology Term
Pfam:PF10288 | Cytoplasmic tRNA 2-thiolation protein 2
Description: CTU2 is a family of proteins necessary for the formation of the wobble nucleoside 5-methoxycarbonylmethyl-2-thiouridine in Saccharomyces cerevisiae. The family is conserved from plants to humans ]1]. It plays a central role in the 2-thiolation of 5-methoxycarbonylmethyl-2-thiouridine, or the wobble nucleoside [2]. This wobble modification in tRNAs, 5-methoxycarbonylmethyl-2-thiouridine (mcm(5)s(2)U), is required for the proper decoding of NNR codons in eukaryotes. The 2-thio group gives rigidity by largely fixing the C3'-endo ribose puckering, ensuring stable and accurate codon-anticodon pairing [3].
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Ontology Term
Pfam:PF02514 | CobN/Magnesium Chelatase
Description: This family contains a domain common to the cobN protein and to magnesium protoporphyrin chelatase. CobN is implicated in the conversion of hydrogenobyrinic acid a,c-diamide to cobyrinic acid [1]. Magnesium protoporphyrin chelatase is involved in chlorophyll biosynthesis [2].
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Ontology Term
Pfam:PF11965 | Domain of unknown function (DUF3479)
Description: This presumed domain is functionally uncharacterised. This domain is found in bacteria, archaea and eukaryotes. This domain is about 160 amino acids in length. This domain is found associated with Pfam:PF02514.
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Ontology Term
PANTHER:PTHR12444:SF0 | PROTEIN EFR3 HOMOLOG CMP44E
 
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Ontology Term
PANTHER:PTHR14677 | ARSENITE INDUCUBLE RNA ASSOCIATED PROTEIN AIP-1-RELATED
 
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Ontology Term
PANTHER:PTHR31268 | FAMILY NOT NAMED
 
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Ontology Term
Pfam:PF05691 | Raffinose synthase or seed imbibition protein Sip1
Description: This family consists of several raffinose synthase proteins, also known as seed imbibition (Sip1) proteins. Raffinose (O-alpha- D-galactopyranosyl- (1-->6)- O-alpha- D-glucopyranosyl-(1<-->2)- O-beta- D-fructofuranoside) is a widespread oligosaccharide in plant seeds and other tissues. Raffinose synthase (EC:2.4.1.82) is the key enzyme that channels sucrose into the raffinose oligosaccharide pathway [1]. Raffinose family oligosaccharides (RFOs) are ubiquitous in plant seeds and are thought to play critical roles in the acquisition of tolerance to desiccation and seed longevity. Raffinose synthases are alkaline alpha-galactosidases and are solely responsible for RFO breakdown in germinating maize seeds, whereas acidic galactosidases appear to have other functions [2]. Glycoside hydrolase family 36 can be split into 11 families, GH36A to GH36K [3]. This family includes enzymes from GH36C.
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Ontology Term
PANTHER:PTHR23117 | GUANYLATE KINASE-RELATED
 
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Ontology Term
Pfam:PF00625 | Guanylate kinase
Description: NULL
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Ontology Term
PANTHER:PTHR24015:SF116 | OS04G0602600 PROTEIN
 
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Ontology Term
PANTHER:PTHR11846 | ADENYLOSUCCINATE SYNTHETASE
 
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Ontology Term
Pfam:PF00709 | Adenylosuccinate synthetase
Description: NULL
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Ontology Term
PANTHER:PTHR10634:SF5 | AN1-TYPE ZINC FINGER PROTEIN 3
 
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Ontology Term
PANTHER:PTHR11075 | PEPTIDE CHAIN RELEASE FACTOR
 
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Ontology Term
PANTHER:PTHR11075:SF6 | CLASS I PEPTIDE CHAIN RELEASE FACTOR
 
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Ontology Term
Pfam:PF00472 | RF-1 domain
Description: This domain is found in peptide chain release factors such as RF-1 (Swiss:P07011) and RF-2 (Swiss:P07012), and a number of smaller proteins of unknown function such as Swiss:P40711. This domain contains the peptidyl-tRNA hydrolase activity. The domain contains a highly conserved motif GGQ, where the glutamine is thought to coordinate the water that mediates the hydrolysis.
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Ontology Term
Pfam:PF03462 | PCRF domain
Description: This domain is found in peptide chain release factors.
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Ontology Term
PANTHER:PTHR31593 | FAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR21227 | TRNA-SPLICING ENDONUCLEASE SUBUNIT SEN2
 
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Ontology Term
Pfam:PF01974 | tRNA intron endonuclease, catalytic C-terminal domain
Description: Members of this family cleave pre tRNA at the 5' and 3' splice sites to release the intron EC:3.1.27.9.
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Ontology Term
PANTHER:PTHR13617 | PROTEIN ABHD18
 
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Ontology Term
Pfam:PF09752 | Alpha/beta hydrolase domain containing 18
Description: This entry represents alpha/beta hydrolase domain-containing protein 18 (ABHD18). Its function is not clear.
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Ontology Term
Pfam:PF13589 | Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Description: This family represents, additionally, the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
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Ontology Term
Pfam:PF14144 | Seed dormancy control
Description: This family of plant proteins appears to be a highly specific controller seed dormancy.
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Ontology Term
PANTHER:PTHR16052 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR16052:SF0 | TBCC DOMAIN-CONTAINING PROTEIN 1
 
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Ontology Term
Pfam:PF07986 | Tubulin binding cofactor C
Description: Members of this family are involved in the folding pathway of tubulins and form a beta helix structure [2].
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Ontology Term
PANTHER:PTHR14110 | MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22
 
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Ontology Term
PANTHER:PTHR14110:SF0 | MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM22
 
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Ontology Term
PANTHER:PTHR16140 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF08743 | Nse4 C-terminal
Description: Nse4 is the kleisin component of the Smc5/6 DNA repair complex. It bridges the heads of Smc5 and Smc6 [1,2,3,4]. This is the C-terminal domain of Nse4 that interacts with the head domain of Smc5 [4].
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Ontology Term
PANTHER:PTHR10288:SF5 | ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 36-RELATED
 
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Ontology Term
Pfam:PF14608 | RNA-binding, Nab2-type zinc finger
Description: This is an unusual zinc-finger family, and is represented by fingers 5-7 of Nab2. Nab2 ZnF5-7 are zinc-fingers of the type C-x8-C-x5-C-x3-H. Nab2 ZnFs function in the generation of export-competent mRNPs. Mab2 is a conserved polyadenosine-RNA-binding Zn finger protein required for both mRNA export and polyadenylation regulation and becomes attached to the mRNP after splicing and during or immediately after polyadenylation. The three ZnFs, 5-7, have almost identical folds and, most unusually, associate with one another to form a single coherent structural unit. ZnF5-7 bind to eight consecutive adenines, and chemical shift perturbations identify residues on each finger that interact with RNA [1].
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Ontology Term
Pfam:PF03760 | Late embryogenesis abundant (LEA) group 1
Description: Family members are conserved along the entire coding region, especially within the hydrophobic internal 20 amino acid motif, which may be repeated.
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Ontology Term
PANTHER:PTHR10416 | DNA POLYMERASE DELTA SUBUNIT 2
 
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Ontology Term
Pfam:PF04042 | DNA polymerase alpha/epsilon subunit B
Description: This family contains a number of DNA polymerase subunits. The B subunit of the DNA polymerase alpha plays an essential role at the initial stage of DNA replication in S. cerevisiae and is phosphorylated in a cell cycle-dependent manner. DNA polymerase epsilon is essential for cell viability and chromosomal DNA replication in budding yeast. In addition, DNA polymerase epsilon may be involved in DNA repair and cell-cycle checkpoint control. The enzyme consists of at least four subunits in mammalian cells as well as in yeast. The largest subunit of DNA polymerase epsilon is responsible for polymerase epsilon is responsible for polymerase activity. In mouse, the DNA polymerase epsilon subunit B is the second largest subunit of the DNA polymerase. A part of the N-terminal was found to be responsible for the interaction with SAP18. Experimental evidence suggests that this subunit may recruit histone deacetylase to the replication fork to modify the chromatin structure [1].
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Ontology Term
PANTHER:PTHR22769 | MUTT/NUDIX HYDROLASE
 
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Ontology Term
Pfam:PF14803 | Nudix N-terminal
Description: Ths domain occurs at the N-terminus of several Nudix (Nucleoside Diphosphate linked to X) hydrolases.
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Ontology Term
PANTHER:PTHR11562 | CATION EFFLUX PROTEIN/ ZINC TRANSPORTER
 
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Ontology Term
Pfam:PF01545 | Cation efflux family
Description: Members of this family are integral membrane proteins, that are found to increase tolerance to divalent metal ions such as cadmium, zinc, and cobalt. These proteins are thought to be efflux pumps that remove these ions from cells.
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Ontology Term
PANTHER:PTHR32410 | CYSTEINE/HISTIDINE-RICH C1 DOMAIN FAMILY PROTEIN
 
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Ontology Term
Pfam:PF03107 | C1 domain
Description: This short domain is rich in cysteines and histidines. The pattern of conservation is similar to that found in Pfam:PF00130, therefore we have termed this domain DC1 for divergent C1 domain. This domain probably also binds to two zinc ions. The function of proteins with this domain is uncertain, however this domain may bind to molecules such as diacylglycerol (A Bateman pers. obs.). This family are found in plant proteins.
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Ontology Term
PANTHER:PTHR13009 | HEAT SHOCK PROTEIN 90 HSP90 CO-CHAPERONE AHA-1
 
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Ontology Term
PANTHER:PTHR13009:SF0 | AHSA1 PROTEIN
 
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Ontology Term
Pfam:PF08327 | Activator of Hsp90 ATPase homolog 1-like protein
Description: This family includes eukaryotic, prokaryotic and archaeal proteins that bear similarity to a C-terminal region of human activator of 90 kDa heat shock protein ATPase homolog 1 (AHSA1/p38, Swiss:O95433). This protein is known to interact with the middle domain of Hsp90, and stimulate its ATPase activity [1]. It is probably a general upregulator of Hsp90 function, particularly contributing to its efficiency in conditions of increased stress [2]. p38 is also known to interact with the cytoplasmic domain of the VSV G protein, and may thus be involved in protein transport [3]. It has also been reported as being underexpressed in Down's syndrome. This region is found repeated in two members of this family (Swiss:Q8XY04 and Swiss:Q6MH87). The structure of YndB from Bacillus subtilis showed the helix-grip fold consisting of a beta-sheet with two small and one long alpha-helix which form a hydrophobic cavity that preferentially binds lipid-like molecules. This structure confirms its similarity with the eukaryote protein Aha1 and its classification as a member of the AHSA1 family) [4].
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Ontology Term
Pfam:PF09229 | Activator of Hsp90 ATPase, N-terminal
Description: Members of this family, which are predominantly found in the protein 'Activator of Hsp90 ATPase' adopt a secondary structure consisting of an N-terminal alpha-helix leading into a four-stranded meandering antiparallel beta-sheet, followed by a C-terminal alpha-helix. The two helices are packed together, with the beta-sheet curving around them. They bind to the molecular chaperone HSP82 and stimulate its ATPase activity [1].
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Ontology Term
PANTHER:PTHR10429 | DNA-3-METHYLADENINE GLYCOSYLASE
 
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USDA
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The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
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