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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF01678 | Diaminopimelate epimerase
Description: Diaminopimelate epimerase contains two domains of the same alpha/beta fold, both contained in this family.
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Ontology Term
PANTHER:PTHR24058:SF0 | SERINE/THREONINE-PROTEIN KINASE DOA
 
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Ontology Term
Pfam:PF13174 | Tetratricopeptide repeat
Description: NULL
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Ontology Term
PANTHER:PTHR12181 | LIPIN
 
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Ontology Term
Pfam:PF08235 | LNS2 (Lipin/Ned1/Smp2)
Description: This domain is found in Saccharomyces cerevisiae protein SMP2, proteins with an N-terminal lipin domain (Pfam: PF04571) [1]. SMP2 (also known as PAH1) is involved in plasmid maintenance and respiration [2], and has been identified as a Mg2+-dependent phosphatidate phosphatase (EC:3.1.3.4) that contains a haloacid dehalogenase (HAD)-like domain [4]. Lipin proteins are involved in adipose tissue development and insulin resistance [3].
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Ontology Term
Pfam:PF04571 | lipin, N-terminal conserved region
Description: Mutations in the lipin gene lead to fatty liver dystrophy in mice. The protein has been shown to be phosphorylated by the TOR Ser/Thr protein kinases in response to insulin stimulation. The conserved region is found at the N-terminus of the member proteins [1,2].
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Ontology Term
PANTHER:PTHR30028 | UPF0014 INNER MEMBRANE PROTEIN YBBM-RELATED
 
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Ontology Term
PANTHER:PTHR30028:SF0 | PROTEIN ALUMINUM SENSITIVE 3
 
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Ontology Term
Pfam:PF03649 | Uncharacterised protein family (UPF0014)
Description: Characterised proteins in this family include probable iron export permease protein FetB, which is part of the ABC transporter complex FetAB, probably involved in iron export [1], and aluminium sensitive 3 protein, also part of an ABC transporter required for aluminum (Al) resistance [2]. This family also includes integral membrane proteins currently uncharacterised.
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Ontology Term
Pfam:PF10536 | Plant mobile domain
Description: This domain was identified by Babu and colleagues in a variety of transposases [1].
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Ontology Term
PANTHER:PTHR21594 | NUCLEAR PROTEIN HCC-1/THO1
 
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Ontology Term
PANTHER:PTHR21594:SF1 | SAP DOMAIN-CONTAINING RIBONUCLEOPROTEIN
 
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Ontology Term
PANTHER:PTHR11260:SF77 | GLUTATHIONE S-TRANSFERASE 1
 
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Ontology Term
PANTHER:PTHR21403 | ATP PHOSPHORIBOSYLTRANSFERASE ATP-PRTASE
 
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Ontology Term
Pfam:PF01634 | ATP phosphoribosyltransferase
Description: NULL
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Ontology Term
Pfam:PF08029 | HisG, C-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR12681 | ZINC FINGER-CONTAINING PROTEIN P48ZNF
 
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Ontology Term
PANTHER:PTHR12681:SF0 | ZINC FINGER CCCH DOMAIN-CONTAINING PROTEIN 15
 
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Ontology Term
PANTHER:PTHR19431 | 60S RIBOSOMAL PROTEIN L4
 
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Ontology Term
PANTHER:PTHR19431:SF0 | 60S RIBOSOMAL PROTEIN L4
 
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Ontology Term
Pfam:PF00573 | Ribosomal protein L4/L1 family
Description: This family includes Ribosomal L4/L1 from eukaryotes and archaebacteria and L4 from eubacteria. L4 from yeast has been shown to bind rRNA [1].
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Ontology Term
Pfam:PF14374 | 60S ribosomal protein L4 C-terminal domain
Description: This family is found at the very C-terminal of 60 ribosomal L4 proteins.
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Ontology Term
PANTHER:PTHR13305 | RIBOSOME BIOGENESIS PROTEIN NOP10
 
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Ontology Term
PANTHER:PTHR13305:SF0 | H/ACA RIBONUCLEOPROTEIN COMPLEX SUBUNIT 3
 
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Ontology Term
Pfam:PF04135 | Nucleolar RNA-binding protein, Nop10p family
Description: Nop10p is a nucleolar protein that is specifically associated with H/ACA snoRNAs. It is essential for normal 18S rRNA production and rRNA pseudouridylation by the ribonucleoprotein particles containing H/ACA snoRNAs (H/ACA snoRNPs). Nop10p is probably necessary for the stability of these RNPs [1].
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Ontology Term
PANTHER:PTHR11064 | CCAAT-BINDING TRANSCRIPTION FACTOR-RELATED
 
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Ontology Term
PANTHER:PTHR11630:SF47 | DNA HELICASE MCM8
 
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Ontology Term
PANTHER:PTHR11652 | 30S RIBOSOMAL PROTEIN S12 FAMILY MEMBER
 
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Ontology Term
Pfam:PF00164 | Ribosomal protein S12/S23
Description: This protein is known as S12 in bacteria and archaea and S23 in eukaryotes.
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Ontology Term
PANTHER:PTHR24015:SF65 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR24031:SF33 | ATP-DEPENDENT RNA HELICASE DDX52-RELATED
 
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Ontology Term
PANTHER:PTHR22766 | RING FINGER PROTEIN 24-RELATED
 
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Ontology Term
PANTHER:PTHR23012:SF25 | RING/U-BOX DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR22996 | MAHOGUNIN
 
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Ontology Term
PANTHER:PTHR22996:SF0 | LP12254P-RELATED
 
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Ontology Term
PANTHER:PTHR12713 | VACUOLAR ATP SYNTHASE SUBUNIT G
 
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Ontology Term
Pfam:PF03179 | Vacuolar (H+)-ATPase G subunit
Description: This family represents the eukaryotic vacuolar (H+)-ATPase (V-ATPase) G subunit. V-ATPases generate an acidic environment in several intracellular compartments. Correspondingly, they are found as membrane-attached proteins in several organelles. They are also found in the plasma membranes of some specialised cells. V-ATPases consist of peripheral (V1) and membrane integral (V0) heteromultimeric complexes. The G subunit is part of the V1 subunit, but is also thought to be strongly attached to the V0 complex. It may be involved in the coupling of ATP degradation to H+ translocation.
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Ontology Term
Pfam:PF04520 | Senescence regulator
Description: This protein regulates the expression of proteins associated with leaf senescence in plants [1,2].
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Ontology Term
PANTHER:PTHR11482 | ARGININE/DIAMINOPIMELATE/ORNITHINE DECARBOXYLASE
 
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Ontology Term
PANTHER:PTHR11482:SF5 | GROUP IV DECARBOXYLASE
 
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Ontology Term
Pfam:PF00278 | Pyridoxal-dependent decarboxylase, C-terminal sheet domain
Description: These pyridoxal-dependent decarboxylases act on ornithine, lysine, arginine and related substrates.
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Ontology Term
Pfam:PF02784 | Pyridoxal-dependent decarboxylase, pyridoxal binding domain
Description: These pyridoxal-dependent decarboxylases acting on ornithine, lysine, arginine and related substrates This domain has a TIM barrel fold.
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Ontology Term
PANTHER:PTHR31223 | LOG FAMILY PROTEIN YJL055W
 
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Ontology Term
PANTHER:PTHR31223:SF0 | LOG FAMILY PROTEIN YJL055W
 
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Ontology Term
Pfam:PF03641 | Possible lysine decarboxylase
Description: The members of this family share a highly conserved motif PGGXGTXXE that is probably functionally important. This family includes proteins annotated as lysine decarboxylases, although the evidence for this is not clear.
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Ontology Term
PANTHER:PTHR10799:SF460 | CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 3-RELATED
 
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Ontology Term
PANTHER:PTHR10584:SF24 | ADENOSINE KINASE
 
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Ontology Term
PANTHER:PTHR10741 | TRANSLIN AND TRANSLIN ASSOCIATED PROTEIN X
 
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Ontology Term
PANTHER:PTHR10741:SF2 | TRANSLIN
 
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Ontology Term
Pfam:PF01997 | Translin family
Description: Members of this family include Translin Swiss:Q15631 that interacts with DNA and forms a ring around the DNA. This family also includes Swiss:Q99598, that was found to interact with translin with yeast two-hybrid screen [1].
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Ontology Term
PANTHER:PTHR30603 | RNA POLYMERASE SIGMA FACTOR RPO
 
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Ontology Term
Pfam:PF04542 | Sigma-70 region 2
Description: Region 2 of sigma-70 is the most conserved region of the entire protein. All members of this class of sigma-factor contain region 2. The high conservation is due to region 2 containing both the -10 promoter recognition helix and the primary core RNA polymerase binding determinant. The core binding helix, interacts with the clamp domain of the largest polymerase subunit, beta prime [1,2]. The aromatic residues of the recognition helix, found at the C-terminus of this domain are though to mediate strand separation, thereby allowing transcription initiation [1,2].
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Ontology Term
Pfam:PF04539 | Sigma-70 region 3
Description: Region 3 forms a discrete compact three helical domain within the sigma-factor. Region is not normally involved in the recognition of promoter DNA, but as some specific bacterial promoters containing an extended -10 promoter element, residues within region 3 play an important role. Region 3 primarily is involved in binding the core RNA polymerase in the holoenzyme [1].
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Ontology Term
Pfam:PF04545 | Sigma-70, region 4
Description: Region 4 of sigma-70 like sigma-factors are involved in binding to the -35 promoter element via a helix-turn-helix motif [1]. Due to the way Pfam works, the threshold has been set artificially high to prevent overlaps with other helix-turn-helix families. Therefore there are many false negatives.
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Ontology Term
Pfam:PF02359 | Cell division protein 48 (CDC48), N-terminal domain
Description: This domain has a double psi-beta barrel fold and includes VCP-like ATPase and N-ethylmaleimide sensitive fusion protein N-terminal domains. Both the VAT and NSF N-terminal functional domains consist of two structural domains of which this is at the N-terminus. The VAT-N domain found in AAA ATPases Pfam:PF00004 is a substrate 185-residue recognition domain [1].
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Ontology Term
PANTHER:PTHR21181 | FAMILY NOT NAMED
 
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Ontology Term
Pfam:PF10270 | Membrane magnesium transporter
Description: This entry represents a novel family of membrane magnesium transporters (MMgT) [1]. The proteins, MMgT1 and MMgT2, are localised to the Golgi complex and post-Golgi vesicles, including the early endosomes, suggesting that they may provide regulated pathways for Mg(2+) transport in the Golgi and post-Golgi organelles of epithelium-derived cells [1].
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Ontology Term
PANTHER:PTHR22814:SF13 | F13E7.9 PROTEIN-RELATED
 
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Ontology Term
Pfam:PF03129 | Anticodon binding domain
Description: This domain is found in histidyl, glycyl, threonyl and prolyl tRNA synthetases [1] it is probably the anticodon binding domain [2].
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Ontology Term
Pfam:PF13393 | Histidyl-tRNA synthetase
Description: This is a family of class II aminoacyl-tRNA synthetase-like and ATP phosphoribosyltransferase regulatory subunits.
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Ontology Term
PANTHER:PTHR11964 | S-ADENOSYLMETHIONINE SYNTHETASE
 
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Ontology Term
Pfam:PF00438 | S-adenosylmethionine synthetase, N-terminal domain
Description: The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.
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Ontology Term
Pfam:PF02772 | S-adenosylmethionine synthetase, central domain
Description: The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.
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Ontology Term
PANTHER:PTHR10438:SF126 | THIOREDOXIN
 
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Ontology Term
PANTHER:PTHR23293 | FAD SYNTHETASE-RELATED FMN ADENYLYLTRANSFERASE
 
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Ontology Term
Pfam:PF00994 | Probable molybdopterin binding domain
Description: This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor. The domain is presumed to bind molybdopterin. The structure of this domain is known, and it forms an alpha/beta structure. In the known structure of Gephyrin this domain mediates trimerisation [1].
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Ontology Term
Pfam:PF01507 | Phosphoadenosine phosphosulfate reductase family
Description: This domain is found in phosphoadenosine phosphosulfate (PAPS) reductase enzymes or PAPS sulfotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases [1]. The enzyme uses thioredoxin as an electron donor for the reduction of PAPS to phospho-adenosine-phosphate (PAP) [1,2]. It is also found in NodP nodulation protein P from Rhizobium which has ATP sulfurylase activity (sulfate adenylate transferase) [3].
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Ontology Term
PANTHER:PTHR24015:SF139 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF13259 | Protein of unknown function (DUF4050)
Description: This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 109 and 173 amino acids in length. There are two conserved sequence motifs: IPL and FLVD.
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Ontology Term
PANTHER:PTHR16047 | RFWD3 PROTEIN
 
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Ontology Term
PANTHER:PTHR16047:SF7 | E3 UBIQUITIN-PROTEIN LIGASE RFWD3
 
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Ontology Term
PANTHER:PTHR10257 | SERINE/THREONINE PROTEIN PHOSPHATASE 2A PP2A REGULATORY SUBUNIT B
 
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Ontology Term
Pfam:PF01603 | Protein phosphatase 2A regulatory B subunit (B56 family)
Description: Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and metabolism. The ability of this widely distributed heterotrimeric enzyme to act on a diverse array of substrates is largely controlled by the nature of its regulatory B subunit. There are multiple families of B subunits (See also Pfam:PF01240), this family is called the B56 family [1].
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Ontology Term
PANTHER:PTHR24073:SF285 | RAS-RELATED PROTEIN RAB-18
 
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Ontology Term
PANTHER:PTHR19853 | WD REPEAT CONTAINING PROTEIN 3 WDR3
 
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Ontology Term
PANTHER:PTHR19853:SF0 | WD REPEAT-CONTAINING PROTEIN 3
 
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Ontology Term
Pfam:PF04003 | Dip2/Utp12 Family
Description: This domain is found at the C-terminus of proteins containing WD40 repeats. These proteins are part of the U3 ribonucleoprotein the yeast protein is called Utp12 or DIP2 Swiss:Q12220 [1].
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Ontology Term
PANTHER:PTHR13678 | VACUOLAR PROTEIN SORTING-ASSOCIATED PROTEIN 37
 
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Ontology Term
Pfam:PF07200 | Modifier of rudimentary (Mod(r)) protein
Description: This family represents a conserved region approximately 150 residues long within a number of eukaryotic proteins that show homology with Drosophila melanogaster Modifier of rudimentary (Mod(r)) proteins. The N-terminal half of Mod(r) proteins is acidic, whereas the C-terminal half is basic [1], and both of these regions are represented in this family. Members of this family include the Vps37 subunit of the endosomal sorting complex ESCRT-I, a complex involved in recruiting transport machinery for protein sorting at the multivesicular body (MVB). The yeast ESCRT-I complex consists of three proteins (Vps23, Vps28 and Vps37). The mammalian homologue of Vps37 interacts with Tsg101 (Pfam: PF05743) through its mod(r) domain and its function is essential for lysosomal sorting of EGF receptors [2].
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Ontology Term
PANTHER:PTHR21737 | POLYGLUTAMINE BINDING PROTEIN 1/MARVEL MEMBRANE-ASSOCIATING DOMAIN CONTAINING 3
 
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Ontology Term
PANTHER:PTHR21737:SF4 | CACTIN
 
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Ontology Term
Pfam:PF09732 | Cactus-binding C-terminus of cactin protein
Description: CactinC_cactus is the C-terminal 200 residues of the cactin protein which are necessary for the association of cactin with IkappaB-cactus as one of the intracellular members of the Rel complex. The Rel (NF-kappaB) pathway is conserved in invertebrates and vertebrates. In mammals, it controls the activities of the immune and inflammatory response genes as well as viral genes, and is critical for cell growth and survival. In Drosophila, the Rel pathway functions in the innate cellular and humoral immune response, in muscle development, and in the establishment of dorsal-ventral polarity in the early embryo [1]. Most members of the family also have a Cactin_mid domain Pfam:PF10312 further upstream.
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Ontology Term
PANTHER:PTHR24015:SF131 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF02987 | Late embryogenesis abundant protein
Description: Different types of LEA proteins are expressed at different stages of late embryogenesis in higher plant seed embryos and under conditions of dehydration stress. The function of these proteins is unknown.
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Ontology Term
PANTHER:PTHR10792 | 60S RIBOSOMAL PROTEIN L24
 
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Ontology Term
PANTHER:PTHR10792:SF1 | TRASH DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF01246 | Ribosomal protein L24e
Description: NULL
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Ontology Term
PANTHER:PTHR31960 | F-BOX PROTEIN PP2-A15
 
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Ontology Term
PANTHER:PTHR31371 | BNAC09G50660D PROTEIN
 
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Ontology Term
Pfam:PF05003 | Protein of unknown function (DUF668)
Description: This entry represents the C-terminal domain of PSI proteins from Arabidopsis. This domain is found associated with Pfam:PF11961. PSI1 was identified as a gene that is co-expressed with the phytosulfokine (PSK) receptor genes PSKR1 and PSKR2 in Arabidopsis thaliana. PSI proteins are plant-specific and promote growth [1].
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Ontology Term
Pfam:PF11961 | Domain of unknown function (DUF3475)
Description: This entry represents the N-terminal domain of PSI proteins from Arabidopsis. This domain is found associated with Pfam:PF05003. PSI1 was identified as a gene that is co-expressed with the phytosulfokine (PSK) receptor genes PSKR1 and PSKR2 in Arabidopsis thaliana. PSI proteins are plant-specific and promote growth [1].
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Ontology Term
PANTHER:PTHR11902 | ENOLASE
 
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Ontology Term
Pfam:PF03952 | Enolase, N-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR31802 | 32 KDA HEAT SHOCK PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR10359 | A/G-SPECIFIC ADENINE GLYCOSYLASE/ENDONUCLEASE III
 
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Ontology Term
Pfam:PF00730 | HhH-GPD superfamily base excision DNA repair protein
Description: This family contains a diverse range of structurally related DNA repair proteins. The superfamily is called the HhH-GPD family after its hallmark Helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [2]. This includes endonuclease III, EC:4.2.99.18 and MutY an A/G-specific adenine glycosylase, both have a C terminal 4Fe-4S cluster. The family also includes 8-oxoguanine DNA glycosylases such as Swiss:P53397. The methyl-CPG binding protein MBD4 Swiss:Q9Z2D7 also contains a related domain [1] that is a thymine DNA glycosylase. The family also includes DNA-3-methyladenine glycosylase II EC:3.2.2.21 and other members of the AlkA family.
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Ontology Term
Pfam:PF15628 | RRM in Demeter
Description: This is a predicted RRM-fold domain present at the C-terminus of Demeter-like glycoslyases [1]. These proteins are involved in DNA demethylation in plants where they catalyze removal of the 5mC base and subsequently cleave the backbone through lyase activity. Orthologs of Demeter are present in plants and stramenopiles. The RRM fold domain is predicted to facilitate interaction of the catalytic domain with ssDNA or regulatory RNA [1].
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Ontology Term
PANTHER:PTHR12821 | BYSTIN
 
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Ontology Term
Pfam:PF05291 | Bystin
Description: Trophinin and tastin form a cell adhesion molecule complex that potentially mediates an initial attachment of the blastocyst to uterine epithelial cells at the time of implantation. Trophinin and tastin bind to an intermediary cytoplasmic protein called bystin. Bystin may be involved in implantation and trophoblast invasion because bystin is found with trophinin and tastin in the cells at human implantation sites and also in the intermediate trophoblasts at invasion front in the placenta from early pregnancy [1]. This family also includes the yeast protein ENP1. ENP1 is an essential protein in Saccharomyces cerevisiae and is localised in the nucleus [2]. It is thought that ENP1 plays a direct role in the early steps of rRNA processing as enp1 defective yeast cannot synthesise 20S pre-rRNA and hence 18S rRNA, which leads to reduced formation of 40S ribosomal subunits [3].
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Ontology Term
PANTHER:PTHR15921 | PRE-MRNA CLEAVAGE COMPLEX II
 
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