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Search results 4601 to 4700 out of 202262 for *

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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF11717 | RNA binding activity-knot of a chromodomain
Description: This is a novel knotted tudor domain which is required for binding to RNA. The know influences the loop conformation of the helical turn Ht2 - residues 61-6 3- that is located at the side opposite the knot in the tudor domain-chromodomain; stabilisation of Ht2 is essential for RNA binding [1].
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Ontology Term
Pfam:PF02845 | CUE domain
Description: CUE domains have been shown to bind ubiquitin [3-4]. It has been suggested that CUE domains are related to Pfam:PF00627 [4] and this has been confirmed by the structure of the domain [5]. CUE domains also occur in two protein of the IL-1 signal transduction pathway, tollip and TAB2 [2].
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Ontology Term
PANTHER:PTHR13693 | CLASS II AMINOTRANSFERASE/8-AMINO-7-OXONONANOATE SYNTHASE
 
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Ontology Term
PANTHER:PTHR31585 | FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC
 
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Ontology Term
PANTHER:PTHR31585:SF0 | FOLATE-BIOPTERIN TRANSPORTER 1, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF03092 | BT1 family
Description: Members of this family are transmembrane proteins. Several are Leishmania putative proteins that are thought to be pteridine transporters. One such protein Swiss:Q25272, previously termed (and is still annotated as) ORFG, was shown to encode a biopterin transport protein using null mutants [1], thus being subsequently renamed BT1. The significant similarity of ORFG/BT1 to Trypanosoma brucei ESAG10 (a putative transmembrane protein and another member of this family) was previously noted [2]. This family also contains five putative Arabidopsis thaliana proteins of unknown function. In addition, it also contains two predicted prokaryotic proteins (from the cyanobacteria Synechocystis and Synechococcus).
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Ontology Term
PANTHER:PTHR21096 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF05811 | Eukaryotic protein of unknown function (DUF842)
Description: This family consists of a number of conserved eukaryotic proteins of unknown function. The sequences carry three sets of CxxxC motifs, which might suggest a type of zinc-finger formation.
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Ontology Term
PANTHER:PTHR10130 | PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR PEX5
 
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Ontology Term
PANTHER:PTHR10130:SF0 | GH08708P
 
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Ontology Term
PANTHER:PTHR10540 | EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT F-RELATED
 
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Ontology Term
PANTHER:PTHR10540:SF8 | COP9 SIGNALOSOME COMPLEX SUBUNIT 6
 
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Ontology Term
Pfam:PF13012 | Maintenance of mitochondrial structure and function
Description: This is C-terminal to the Mov24 region of the yeast proteasomal subunit Rpn11 and seems likely to regulate the mitochondrial fission and tubulation processes, ie the outer mitochondrial membrane proteins. This function appears to be unrelated to the proteasome activity of the N-terminal region [1].
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Ontology Term
Pfam:PF01241 | Photosystem I psaG / psaK
Description: NULL
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Ontology Term
PANTHER:PTHR11208 | RNA-BINDING PROTEIN RELATED
 
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Ontology Term
PANTHER:PTHR11994 | 60S RIBOSOMAL PROTEIN L11-RELATED
 
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Ontology Term
Pfam:PF00281 | Ribosomal protein L5
Description: NULL
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Ontology Term
Pfam:PF00673 | ribosomal L5P family C-terminus
Description: This region is found associated with Pfam:PF00281.
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Ontology Term
PANTHER:PTHR10721 | MITOCHONDRIAL IMPORT INNER MEMBRANE TRANSLOCASE SUBUNIT TIM44
 
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Ontology Term
Pfam:PF04280 | Tim44-like domain
Description: Tim44 is an essential component of the machinery that mediates the translocation of nuclear-encoded proteins across the mitochondrial inner membrane [1]. Tim44 is thought to bind phospholipids of the mitochondrial inner membrane both by electrostatic interactions and by penetrating the polar head group region [1]. This family includes the C-terminal region of Tim44 that has been shown to form a stable proteolytic fragment in yeast. This region is also found in a set of smaller bacterial proteins. The molecular function of the bacterial members of this family is unknown but transport seems likely. The crystal structure of the C terminal of Tim44 has revealed a large hydrophobic pocket which might play an important role in interacting with the acyl chains of lipid molecules in the mitochondrial membrane [3].
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Ontology Term
PANTHER:PTHR13069 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR11739 | CITRATE SYNTHASE
 
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Ontology Term
PANTHER:PTHR22814:SF47 | HEAVY METAL TRANSPORT/DETOXIFICATION DOMAIN-CONTAINING PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR11649:SF32 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF10396 | GTP-binding protein TrmE N-terminus
Description: This family represents the shorter, B, chain of the homo-dimeric structure which is a guanine nucleotide-binding protein that binds and hydrolyses GTP. TrmE is homologous to the tetrahydrofolate-binding domain of N,N-dimethylglycine oxidase and indeed binds formyl-tetrahydrofolate. TrmE actively participates in the formylation reaction of uridine and regulates the ensuing hydrogenation reaction of a Schiff's base intermediate. This B chain is the N-terminal portion of the protein consisting of five beta-strands and three alpha helices and is necessary for mediating dimer formation within the protein [1].
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Ontology Term
Pfam:PF12631 | MnmE helical domain
Description: The tRNA modification GTPase MnmE consists of three domains. An N-terminal domain, a helical domain and a GTPase domain which is nested within the helical domain. This family represents the helical domain [1-2].
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Ontology Term
PANTHER:PTHR18866:SF6 | PROTEIN POD-2, ISOFORM C
 
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Ontology Term
Pfam:PF02785 | Biotin carboxylase C-terminal domain
Description: Biotin carboxylase is a component of the acetyl-CoA carboxylase multi-component enzyme which catalyses the first committed step in fatty acid synthesis in animals, plants and bacteria. Most of the active site residues reported in reference [1] are in this C-terminal domain.
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Ontology Term
Pfam:PF08326 | Acetyl-CoA carboxylase, central region
Description: The region featured in this family is found in various eukaryotic acetyl-CoA carboxylases, N-terminal to the catalytic domain (Pfam:PF01039). This enzyme (EC:6.4.1.2) is involved in the synthesis of long-chain fatty acids, as it catalyses the rate-limiting step in this process.
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Ontology Term
PANTHER:PTHR31614 | PROTEIN DOWNSTREAM OF FLC-RELATED
 
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Ontology Term
PANTHER:PTHR11931 | PHOSPHOGLYCERATE MUTASE
 
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Ontology Term
PANTHER:PTHR11931:SF0 | PHOSPHOGLYCERATE MUTASE
 
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Ontology Term
PANTHER:PTHR22847:SF100 | TRANSDUCIN/WD40 DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR17985 | SER/THR-RICH PROTEIN T10 IN DGCR REGION
 
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Ontology Term
PANTHER:PTHR17985:SF8 | TRANSPORT AND GOLGI ORGANIZATION PROTEIN 2 HOMOLOG
 
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Ontology Term
Pfam:PF05742 | Transport and Golgi organisation 2
Description: In eukaryotes this family is predicted to play a role in protein secretion and Golgi organisation [1]. In plants this family includes Swiss:A9X6Y0, which is involved in water permeability in the cuticles of fruit [2]. Swiss:P54797 has been found to be expressed during early embryogenesis in mice [3]. This protein contains a conserved NRDE motif. This gene has been characterised in Drosophila melanogaster and named as transport and Golgi organisation 2, hence the name Tango2.
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Ontology Term
PANTHER:PTHR31852:SF0 | NDR1/HIN1-LIKE PROTEIN 13
 
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Ontology Term
PANTHER:PTHR32227:SF11 | GLUCAN ENDO-1,3-BETA-D-GLUCOSIDASE
 
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Ontology Term
PANTHER:PTHR12292 | RWD DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR11937:SF21 | ACTIN-RELATED PROTEIN 6
 
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Ontology Term
PANTHER:PTHR13265 | THO COMPLEX SUBUNIT 1
 
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Ontology Term
Pfam:PF11957 | THO complex subunit 1 transcription elongation factor
Description: The THO complex plays a role in coupling transcription elongation to mRNA export. It is composed of subunits THP2, HPR1, THO2 and MFT1 [1]. The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm [2,3].
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Ontology Term
Pfam:PF12756 | C2H2 type zinc-finger (2 copies)
Description: This family contains two copies of a C2H2-like zinc finger domain.
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Ontology Term
Pfam:PF12847 | Methyltransferase domain
Description: Protein in this family function as methyltransferases.
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Ontology Term
PANTHER:PTHR15893 | RIBOSOMAL PROTEIN L27
 
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Ontology Term
Pfam:PF01016 | Ribosomal L27 protein
Description: NULL
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Ontology Term
Pfam:PF13445 | RING-type zinc-finger
Description: This zinc-finger is a typical RING-type of plant ubiquitin ligases [1].
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Ontology Term
PANTHER:PTHR13586:SF0 | TRAILER HITCH, ISOFORM H
 
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Ontology Term
Pfam:PF08615 | Ribonuclease H2 non-catalytic subunit (Ylr154p-like)
Description: This entry represents the non-catalytic subunit of RNase H2, which in S. cerevisiae is Ylr154p/Rnh203p Swiss:Q12338 (. Whereas bacterial and archaeal RNases H2 are active as single polypeptides, the Saccharomyces cerevisiae homologue, Rnh2Ap, when expressed in Escherichia coli, fails to produce an active RNase H2. For RNase H2 activity three proteins are required [Rnh2Ap (Rnh201p), Ydr279p (Rnh202p) and Ylr154p (Rnh203p)]. Deletion of any one of the proteins or mutations in the catalytic site in Rnh2A leads to loss of RNase H2 activity [1]. RNase H2 ia an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. It participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication.
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Ontology Term
Pfam:PF13369 | Transglutaminase-like superfamily
Description: NULL
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Ontology Term
PANTHER:PTHR32206 | FAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR32206:SF0 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF07287 | Acyclic terpene utilisation family protein AtuA
Description: This family consists of several bacterial and plant proteins of around 400 residues in length. One member of this family has been characterised in Pseudomonas citronellolis as AtuA, a member of a gene cluster that is essential for the acyclic terpene utilisation (Atu) pathway [1].
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Ontology Term
Pfam:PF07985 | SRR1 domain
Description: SRR1 proteins are signalling proteins involved in regulating the circadian clock in Arabidopsis[1]. This presumed domain has a Rossmann-like fold and structural models suggest it may have a methyltransferase function.
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Ontology Term
Pfam:PF00191 | Annexin
Description: This family of annexins also includes giardin that has been shown to function as an annexin [1].
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Ontology Term
Pfam:PF02670 | 1-deoxy-D-xylulose 5-phosphate reductoisomerase
Description: This is a family of 1-deoxy-D-xylulose 5-phosphate reductoisomerases. This enzyme catalyses the formation of 2-C-methyl-D-erythritol 4-phosphate from 1-deoxy-D-xylulose-5-phosphate in the presence of NADPH [1]. This reaction is part of the terpenoid biosynthesis pathway.
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Ontology Term
PANTHER:PTHR22734 | U3 SMALL NUCLEOLAR RIBONUCLEOPROTEIN PROTEIN IMP4
 
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Ontology Term
Pfam:PF04427 | Brix domain
Description: NULL
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Ontology Term
Pfam:PF11883 | Domain of unknown function (DUF3403)
Description: This domain is functionally uncharacterised. This domain is found in eukaryotes. This presumed domain is about 50 amino acids in length. This domain is found associated with Pfam:PF00069, Pfam:PF08276, Pfam:PF00954, Pfam:PF01453.
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Ontology Term
PANTHER:PTHR11255 | DIACYLGLYCEROL KINASE
 
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Ontology Term
Pfam:PF00609 | Diacylglycerol kinase accessory domain
Description: Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. This domain is assumed to be an accessory domain: its function is unknown.
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Ontology Term
Pfam:PF00781 | Diacylglycerol kinase catalytic domain
Description: Diacylglycerol (DAG) is a second messenger that acts as a protein kinase C activator. The catalytic domain is assumed from the finding of bacterial homologues. YegS is the Escherichia coli protein in this family whose crystal structure reveals an active site in the inter-domain cleft formed by four conserved sequence motifs, revealing a novel metal-binding site. The residues of this site are conserved across the family [5].
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Ontology Term
Pfam:PF12807 | Translation initiation factor eIF3 subunit 135
Description: Translation initiation factor eIF3 is a multi-subunit protein complex required for initiation of protein biosynthesis in eukaryotic cells. The complex promotes ribosome dissociation, the binding of the initiator methionyl-tRNA to the 40 S ribosomal subunit, and mRNA recruitment to the ribosome. The protein product from TIF31 genes in yeast is p135 which associates with the eIF3 but does not seem to be necessary for protein translation initiation [1].
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Ontology Term
Pfam:PF15044 | Mitochondrial function, CLU-N-term
Description: CLU_N is the N-terminal domain of the Clueless protein, also known as TIF31-like in other organisms. The function of this domain is not known. It family is found in association with Pfam:PF13236.
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Ontology Term
PANTHER:PTHR12683 | CDK-ACTIVATING KINASE ASSEMBLY FACTOR MAT1
 
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Ontology Term
PANTHER:PTHR12683:SF10 | OS09G0423300 PROTEIN
 
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Ontology Term
PANTHER:PTHR10102 | DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL
 
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Ontology Term
PANTHER:PTHR10102:SF0 | DNA-DIRECTED RNA POLYMERASE, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF00940 | DNA-dependent RNA polymerase
Description: This is a family of single chain RNA polymerases.
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Ontology Term
Pfam:PF14700 | DNA-directed RNA polymerase N-terminal
Description: This is the N-terminal domain of DNA-directed RNA polymerase. This domain has a role in interaction with regions of upstream promoter DNA and the nascent RNA chain, leading to the processivity of the enzyme [1]. In order to make mRNA transcripts the RNA polymerase undergoes a transition from the initiation phase (which only makes short fragments of RNA) to an elongation phase. This domain undergoes a structural change in the transition from initiation to elongation phase. The structural change results in abolition of the promoter binding site, creation of a channel accommodating the heteroduplex in the active site and formation of an exit tunnel which the RNA transcript passes through after peeling off the heteroduplex [2].
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Ontology Term
PANTHER:PTHR12914 | PARTNER OF SLD5
 
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Ontology Term
PANTHER:PTHR11710 | 40S RIBOSOMAL PROTEIN S19
 
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Ontology Term
Pfam:PF01090 | Ribosomal protein S19e
Description: NULL
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Ontology Term
PANTHER:PTHR11692 | BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH
 
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Ontology Term
PANTHER:PTHR11692:SF0 | BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN ATIC
 
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Ontology Term
Pfam:PF01808 | AICARFT/IMPCHase bienzyme
Description: This is a family of bifunctional enzymes catalysing the last two steps in de novo purine biosynthesis. The bifunctional enzyme is found in both prokaryotes and eukaryotes. The second last step is catalysed by 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase EC:2.1.2.3 (AICARFT), this enzyme catalyses the formylation of AICAR with 10-formyl-tetrahydrofolate to yield FAICAR and tetrahydrofolate [1]. This is catalysed by a pair of C-terminal deaminase fold domains in the protein [3], where the active site is formed by the dimeric interface of two monomeric units [3]. The last step is catalysed by the N-terminal IMP (Inosine monophosphate) cyclohydrolase domain EC:3.5.4.10 (IMPCHase), cyclizing FAICAR (5-formylaminoimidazole-4-carboxamide ribonucleotide) to IMP [1].
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Ontology Term
PANTHER:PTHR22603 | CHOLINE/ETHANOALAMINE KINASE
 
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Ontology Term
Pfam:PF01633 | Choline/ethanolamine kinase
Description: Choline kinase catalyses the committed step in the synthesis of phosphatidylcholine by the CDP-choline pathway [1]. This alignment covers the protein kinase portion of the protein. The divergence of this family makes it very difficult to create a model that specifically predicts choline/ethanolamine kinases only. However if [add Pfam ID here for Choline_kinase_C] is also present then it is definitely a member of this family.
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Ontology Term
Pfam:PF04428 | Choline kinase N terminus
Description: Found N terminal to choline/ethanolamine kinase regions (Pfam:PF01633) in some plant and fungal choline kinase enzymes (EC:2.7.1.32). This region is only found in some members of the choline kinase family, and is therefore unlikely to contribute to catalysis.
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Ontology Term
PANTHER:PTHR12899 | 39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL
 
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Ontology Term
PANTHER:PTHR12899:SF3 | 39S RIBOSOMAL PROTEIN L18, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF00861 | Ribosomal L18 of archaea, bacteria, mitoch. and chloroplast
Description: This family includes the large subunit ribosomal proteins from bacteria, archaea, the mitochondria and the chloroplast. It does not include the 60S L18 or L5 proteins from Metazoa.
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Ontology Term
PANTHER:PTHR30053 | ELONGATION FACTOR P
 
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Ontology Term
PANTHER:PTHR30053:SF1 | ELONGATION FACTOR P (EF-P) FAMILY PROTEIN
 
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Ontology Term
Pfam:PF01132 | Elongation factor P (EF-P) OB domain
Description: NULL
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Ontology Term
Pfam:PF08207 | Elongation factor P (EF-P) KOW-like domain
Description: NULL
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Ontology Term
Pfam:PF09285 | Elongation factor P, C-terminal
Description: Members of this family of nucleic acid binding domains are predominantly found in elongation factor P, where they adopt an OB-fold, with five beta-strands forming a beta-barrel in a Greek-key topology [1].
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Ontology Term
PANTHER:PTHR11722 | 60S RIBOSOMAL PROTEIN L13
 
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Ontology Term
PANTHER:PTHR11722:SF0 | 60S RIBOSOMAL PROTEIN L13
 
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Ontology Term
Pfam:PF01294 | Ribosomal protein L13e
Description: NULL
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Ontology Term
Pfam:PF00857 | Isochorismatase family
Description: This family are hydrolase enzymes.
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Ontology Term
PANTHER:PTHR21596:SF8 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF10409 | C2 domain of PTEN tumour-suppressor protein
Description: This is the C2 domain-like domain, in greek key form, of the PTEN protein, phosphatidyl-inositol triphosphate phosphatase, and it is the C-terminus. This domain may well include a CBR3 loop which means it plays a central role in membrane binding. This domain associates across an extensive interface with the N-terminal phosphatase domain DSPc (Pfam:PF00782) suggesting that the C2 domain productively positions the catalytic part of the protein onto the membrane [1].
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Ontology Term
PANTHER:PTHR11819 | SOLUTE CARRIER FAMILY 5
 
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Ontology Term
PANTHER:PTHR11819:SF15 | UREA ACTIVE TRANSPORTER
 
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Ontology Term
Pfam:PF00474 | Sodium:solute symporter family
Description: This family includes Swiss:P33413 which is not in the Prosite entry. Membership of this family is supported by a significant blast score.
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Ontology Term
PANTHER:PTHR22762:SF7 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF13802 | Galactose mutarotase-like
Description: This family is found N-terminal to glycosyl-hydrolase domains, and appears to be similar to the galactose mutarotase superfamily.
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Ontology Term
PANTHER:PTHR22952:SF49 | ABSCISIC ACID-INSENSITIVE 5-LIKE PROTEIN 2-RELATED
 
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Ontology Term
PANTHER:PTHR12233 | VACUOLAR PROTEIN SORTING 26 RELATED
 
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