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Categories

Category: OntologyTerm
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Type Details Score
Ontology Term
PANTHER:PTHR10178 | GAG/POL/ENV POLYPROTEIN
 
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Ontology Term
Pfam:PF00665 | Integrase core domain
Description: Integrase mediates integration of a DNA copy of the viral genome into the host chromosome. Integrase is composed of three domains. The amino-terminal domain is a zinc binding domain Pfam:PF02022. This domain is the central catalytic domain. The carboxyl terminal domain that is a non-specific DNA binding domain Pfam:PF00552. The catalytic domain acts as an endonuclease when two nucleotides are removed from the 3' ends of the blunt-ended viral DNA made by reverse transcription. This domain also catalyses the DNA strand transfer reaction of the 3' ends of the viral DNA to the 5' ends of the integration site [1].
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Ontology Term
Pfam:PF03732 | Retrotransposon gag protein
Description: Gag or Capsid-like proteins from LTR retrotransposons. There is a central motif QGXXEXXXXXFXXLXXH that is common to Retroviridae gag-proteins, but is poorly conserved [1].
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Ontology Term
PANTHER:PTHR24349:SF23 | CALCIUM/CALMODULIN-DEPENDENT PROTEIN KINASE IV
 
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Ontology Term
PANTHER:PTHR10209 | OXIDOREDUCTASE, 2OG-FE II OXYGENASE FAMILY PROTEIN
 
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Ontology Term
Pfam:PF03171 | 2OG-Fe(II) oxygenase superfamily
Description: This family contains members of the 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily [1]. This family includes the C-terminal of prolyl 4-hydroxylase alpha subunit. The holoenzyme has the activity EC:1.14.11.2 catalysing the reaction: Procollagen L-proline + 2-oxoglutarate + O2 <=> procollagen trans- 4-hydroxy-L-proline + succinate + CO2. The full enzyme consists of a alpha2 beta2 complex with the alpha subunit contributing most of the parts of the active site [3]. The family also includes lysyl hydrolases, isopenicillin synthases and AlkB.
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Ontology Term
Pfam:PF14226 | non-haem dioxygenase in morphine synthesis N-terminal
Description: This is the highly conserved N-terminal region of proteins with 2-oxoglutarate/Fe(II)-dependent dioxygenase activity.
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Ontology Term
PANTHER:PTHR12321 | CPG BINDING PROTEIN
 
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Ontology Term
Pfam:PF00628 | PHD-finger
Description: PHD folds into an interleaved type of Zn-finger chelating 2 Zn ions in a similar manner to that of the RING and FYVE domains [2]. Several PHD fingers have been identified as binding modules of methylated histone H3 [3].
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Ontology Term
Pfam:PF12165 | Alfin
Description: The Alfin family includes PHD finger protein Alfin1 and Alfin1-like proteins. Alfin1 is a histone-binding component that specifically recognises H3 tails trimethylated on 'Lys-4' (H3K4me3), which marks transcription start sites of virtually all active genes [1, 2].
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Ontology Term
PANTHER:PTHR14879 | CASPASE REGULATOR, RING FINGER DOMAIN-CONTAINING
 
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Ontology Term
PANTHER:PTHR14879:SF5 | RING-TYPE DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
Pfam:PF13920 | Zinc finger, C3HC4 type (RING finger)
Description: NULL
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Ontology Term
PANTHER:PTHR23032 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR23032:SF1 | BRO1 DOMAIN-CONTAINING PROTEIN BROX
 
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Ontology Term
Pfam:PF13472 | GDSL-like Lipase/Acylhydrolase family
Description: This family of presumed lipases and related enzymes are similar to Pfam:PF00657.
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Ontology Term
Pfam:PF04791 | LMBR1-like membrane protein
Description: Members of this family are integral membrane proteins that are around 500 residues in length. LMBR1 is not involved in preaxial polydactyly, as originally thought [1]. Vertebrate members of this family may play a role in limb development [2]. Lysosomal cobalamin transport escort protein LMBD1 is a lysosomal membrane chaperone required to export cobalamin from lysosome to the cytosol, allowing its conversion to cofactors [3,4]. A member of this family has been shown to be a lipocalin membrane receptor [5].
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Ontology Term
PANTHER:PTHR31652 | LIMR FAMILY PROTEIN DDB_G0283707-RELATED
 
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Ontology Term
PANTHER:PTHR31652:SF0 | LIMR FAMILY PROTEIN DDB_G0283707-RELATED
 
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Ontology Term
PANTHER:PTHR31503 | VACUOLAR CALCIUM ION TRANSPORTER
 
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Ontology Term
PANTHER:PTHR31503:SF0 | LOW AFFINITY VACUOLAR MONOVALENT CATION/H(+) ANTIPORTER
 
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Ontology Term
PANTHER:PTHR11695 | ALCOHOL DEHYDROGENASE RELATED
 
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Ontology Term
PANTHER:PTHR11695:SF269 | ALCOHOL DEHYDROGENASE CLASS-3
 
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Ontology Term
Pfam:PF00107 | Zinc-binding dehydrogenase
Description: NULL
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Ontology Term
Pfam:PF08240 | Alcohol dehydrogenase GroES-like domain
Description: This is the catalytic domain of alcohol dehydrogenases. Many of them contain an inserted zinc binding domain. This domain has a GroES-like structure [1-2].
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Ontology Term
PANTHER:PTHR12770 | RUS1 FAMILY PROTEIN C16ORF58
 
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Ontology Term
Pfam:PF04884 | Vitamin B6 photo-protection and homoeostasis
Description: In plants, this domain plays a role in auxin-transport, plant growth and development [1,2] and appears to be expressed by all cells in the plant as well as in plastids. The family has been shown to play a role in vitamin B6 photo-protection and homoeostasis in plants [3].
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Ontology Term
PANTHER:PTHR15067 | E3 UBIQUITIN-PROTEIN LIGASE RNF8
 
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Ontology Term
PANTHER:PTHR15067:SF7 | E3 UBIQUITIN-PROTEIN LIGASE DMA1-RELATED
 
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Ontology Term
PANTHER:PTHR12383 | PROTEASE FAMILY S26 MITOCHONDRIAL INNER MEMBRANE PROTEASE-RELATED
 
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Ontology Term
PANTHER:PTHR12383:SF3 | MITOCHONDRIAL INNER MEMBRANE PROTEASE SUBUNIT 2
 
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Ontology Term
Pfam:PF00717 | Peptidase S24-like
Description: NULL
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Ontology Term
PANTHER:PTHR13847 | SARCOSINE DEHYDROGENASE-RELATED
 
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Ontology Term
Pfam:PF03226 | Yippee zinc-binding/DNA-binding /Mis18, centromere assembly
Description: This family includes both Yippee-type proteins and Mis18 kinetochore proteins. Yippee are putative zinc-binding/DNA-binding proteins. Mis18 are proteins involved in the priming of centromeres for recruiting CENP-A. Mis18-alpha and beta form part of a small complex with Mis18-binding protein. Mis18-alpha is found to interact with DNA de-methylases through a Leu-rich region located at its carboxyl terminus [5]. This entry also includes the CULT domain proteins such as Cereblon [6].
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Ontology Term
PANTHER:PTHR11361 | DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER
 
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Ontology Term
PANTHER:PTHR11361:SF31 | DNA MISMATCH REPAIR PROTEIN MSH6
 
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Ontology Term
Pfam:PF00488 | MutS domain V
Description: This domain is found in proteins of the MutS family (DNA mismatch repair proteins) and is found associated with Pfam:PF01624, Pfam:PF05188, Pfam:PF05192 and Pfam:PF05190. The mutS family of proteins is named after the Salmonella typhimurium MutS protein involved in mismatch repair; other members of the family included the eukaryotic MSH 1,2,3, 4,5 and 6 proteins. These have various roles in DNA repair and recombination. Human MSH has been implicated in non-polyposis colorectal carcinoma (HNPCC) and is a mismatch binding protein [2]. The aligned region corresponds with domain V of Thermus aquaticus MutS as characterised in [4], which contains a Walker A motif, and is structurally similar to the ATPase domain of ABC transporters.
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Ontology Term
PANTHER:PTHR31949 | GASTRIC MUCIN-LIKE PROTEIN
 
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Ontology Term
PANTHER:PTHR31549 | PROTEIN, PUTATIVE (DUF247)-RELATED-RELATED
 
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Ontology Term
PANTHER:PTHR31549:SF0 | EMB|CAB72473.1
 
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Ontology Term
Pfam:PF03140 | Plant protein of unknown function
Description: The function of the plant proteins constituting this family is unknown.
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Ontology Term
PANTHER:PTHR23081 | RNA POLYMERASE II CTD PHOSPHATASE
 
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Ontology Term
PANTHER:PTHR23081:SF0 | RNA POLYMERASE II SUBUNIT A C-TERMINAL DOMAIN PHOSPHATASE
 
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Ontology Term
Pfam:PF03031 | NLI interacting factor-like phosphatase
Description: This family contains a number of NLI interacting factor isoforms (eg. Swiss:Q9PTJ8) and also an N-terminal regions of RNA polymerase II CTC phosphatase (Swiss:Q9Y5BO) and FCP1 serine phosphatase (Swiss:Q9PT70). This region has been identified as the minimal phosphatase domain [1].
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Ontology Term
PANTHER:PTHR10357 | ALPHA-AMYLASE FAMILY MEMBER
 
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Ontology Term
Pfam:PF00686 | Starch binding domain
Description: NULL
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Ontology Term
PANTHER:PTHR12042 | LACTOSYLCERAMIDE 4-ALPHA-GALACTOSYLTRANSFERASE ALPHA- 1,4-GALACTOSYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR12042:SF4 | ALPHA4GT1-RELATED
 
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Ontology Term
Pfam:PF04572 | Alpha 1,4-glycosyltransferase conserved region
Description: The glycosphingolipids (GSL) form part of eukaryotic cell membranes. They consist of a hydrophilic carbohydrate moiety linked to a hydrophobic ceramide tail embedded within the lipid bilayer of the membrane. Lactosylceramide, Gal1,4Glc1Cer (LacCer), is the common synthetic precursor to the majority of GSL found in vertebrates. Alpha 1.4-glycosyltransferases utilise UDP donors and transfer the sugar to a beta-linked acceptor. This region appears to be confined to higher eukaryotes. No function has been yet assigned to this region [1].
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Ontology Term
PANTHER:PTHR12897 | COLON CANCER-ASSOCIATED PROTEIN MIC1
 
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Ontology Term
PANTHER:PTHR12897:SF4 | REGULATOR OF MON1-CCZ1 COMPLEX
 
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Ontology Term
Pfam:PF07035 | Colon cancer-associated protein Mic1-like
Description: This family represents the C-terminus (approximately 160 residues) of a number of proteins that resemble colon cancer-associated protein Mic1.
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Ontology Term
PANTHER:PTHR21495 | NUCLEOPORIN-RELATED
 
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Ontology Term
Pfam:PF03018 | Dirigent-like protein
Description: This family contains a number of proteins which are induced during disease response in plants. Members of this family are involved in lignification.
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Ontology Term
PANTHER:PTHR10042 | EARLY GROWTH RESPONSE PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR12949 | RNA POLYMERASE III DNA DIRECTED -RELATED
 
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Ontology Term
PANTHER:PTHR12949:SF0 | DNA-DIRECTED RNA POLYMERASE III SUBUNIT RPC3
 
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Ontology Term
Pfam:PF05645 | RNA polymerase III subunit RPC82
Description: This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa [1].
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Ontology Term
Pfam:PF08221 | RNA polymerase III subunit RPC82 helix-turn-helix domain
Description: This family consists of several DNA-directed RNA polymerase III polypeptides which are related to the Saccharomyces cerevisiae RPC82 protein. RNA polymerase C (III) promotes the transcription of tRNA and 5S RNA genes. In Saccharomyces cerevisiae, the enzyme is composed of 15 subunits, ranging from 160 to about 10 kDa [1]. This region is a probably DNA-binding helix-turn-helix.
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Ontology Term
PANTHER:PTHR24282 | CYTOCHROME P450 FAMILY MEMBER
 
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Ontology Term
Pfam:PF00067 | Cytochrome P450
Description: Cytochrome P450s are haem-thiolate proteins [6] involved in the oxidative degradation of various compounds. They are particularly well known for their role in the degradation of environmental toxins and mutagens. They can be divided into 4 classes, according to the method by which electrons from NAD(P)H are delivered to the catalytic site. Sequence conservation is relatively low within the family - there are only 3 absolutely conserved residues - but their general topography and structural fold are highly conserved. The conserved core is composed of a coil termed the 'meander', a four-helix bundle, helices J and K, and two sets of beta-sheets. These constitute the haem-binding loop (with an absolutely conserved cysteine that serves as the 5th ligand for the haem iron), the proton-transfer groove and the absolutely conserved EXXR motif in helix K. While prokaryotic P450s are soluble proteins, most eukaryotic P450s are associated with microsomal membranes. their general enzymatic function is to catalyse regiospecific and stereospecific oxidation of non-activated hydrocarbons at physiological temperatures [6].
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Ontology Term
PANTHER:PTHR22950 | AMINO ACID TRANSPORTER
 
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Ontology Term
Pfam:PF01490 | Transmembrane amino acid transporter protein
Description: This transmembrane region is found in many amino acid transporters including UNC-47 and MTR. UNC-47 encodes a vesicular amino butyric acid (GABA) transporter, (VGAT). UNC-47 is predicted to have 10 transmembrane domains Swiss:P34579 [1]. MTR is a N system amino acid transporter system protein involved in methyltryptophan resistance Swiss:P38680. Other members of this family include proline transporters and amino acid permeases.
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Ontology Term
PANTHER:PTHR19139 | AQUAPORIN TRANSPORTER
 
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Ontology Term
Pfam:PF00230 | Major intrinsic protein
Description: MIP (Major Intrinsic Protein) family proteins exhibit essentially two distinct types of channel properties: (1) specific water transport by the aquaporins, and (2) small neutral solutes transport, such as glycerol by the glycerol facilitators [1].
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Ontology Term
PANTHER:PTHR11439 | GAG-POL-RELATED RETROTRANSPOSON
 
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Ontology Term
Pfam:PF12710 | haloacid dehalogenase-like hydrolase
Description: NULL
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Ontology Term
Pfam:PF10551 | MULE transposase domain
Description: This domain was identified by Babu and colleagues [1].
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Ontology Term
PANTHER:PTHR12526 | GLYCOSYLTRANSFERASE
 
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Ontology Term
Pfam:PF00534 | Glycosyl transferases group 1
Description: Mutations in this domain of Swiss:P37287 lead to disease (Paroxysmal Nocturnal haemoglobinuria). Members of this family transfer activated sugars to a variety of substrates, including glycogen, Fructose-6-phosphate and lipopolysaccharides. Members of this family transfer UDP, ADP, GDP or CMP linked sugars. The eukaryotic glycogen synthases may be distant members of this family.
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Ontology Term
Pfam:PF13579 | Glycosyl transferase 4-like domain
Description: NULL
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Ontology Term
PANTHER:PTHR25040:SF70 | DUPLICATED SANT DNA-BINDING DOMAIN-CONTAINING PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR20981 | 60S RIBOSOMAL PROTEIN L21
 
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Ontology Term
Pfam:PF01157 | Ribosomal protein L21e
Description: NULL
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Ontology Term
PANTHER:PTHR11709 | MULTI-COPPER OXIDASE
 
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Ontology Term
PANTHER:PTHR11709:SF23 | LACCASE-11
 
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Ontology Term
Pfam:PF00394 | Multicopper oxidase
Description: Many of the proteins in this family contain multiple similar copies of this plastocyanin-like domain.
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Ontology Term
Pfam:PF07731 | Multicopper oxidase
Description: This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.
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Ontology Term
Pfam:PF07732 | Multicopper oxidase
Description: This entry contains many divergent copper oxidase-like domains that are not recognised by the Pfam:PF00394 model.
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Ontology Term
Pfam:PF13456 | Reverse transcriptase-like
Description: This domain is found in plants and appears to be part of a retrotransposon.
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Ontology Term
PANTHER:PTHR31659 | PROTEIN: UPF0503-LIKE PROTEIN, PUTATIVE (DUF740)-RELATED
 
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Ontology Term
Pfam:PF05340 | Protein of unknown function (DUF740)
Description: This family consists of several uncharacterised plant proteins of unknown function.
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Ontology Term
PANTHER:PTHR11908 | XANTHINE DEHYDROGENASE
 
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Ontology Term
Pfam:PF02738 | Molybdopterin cofactor-binding domain
Description: NULL
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Ontology Term
Pfam:PF06127 | 2-hydroxy-palmitic acid dioxygenase Mpo1-like
Description: Budding yeast Mpo1 is a dioxygenase that catalyzes the alpha-oxidation of a 2-hydroxy fatty acid in an Fe2+-dependent manner [1]. This entry also includes Mpo1 homologues from bacteria, fungi and plants. Their function is not clear.
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Ontology Term
PANTHER:PTHR10367 | MRNA-CAPPING ENZYME
 
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Ontology Term
PANTHER:PTHR10367:SF0 | MRNA-CAPPING ENZYME
 
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Ontology Term
Pfam:PF00782 | Dual specificity phosphatase, catalytic domain
Description: Ser/Thr and Tyr protein phosphatases. The enzyme's tertiary fold is highly similar to that of tyrosine-specific phosphatases, except for a "recognition" region [2].
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Ontology Term
Pfam:PF01331 | mRNA capping enzyme, catalytic domain
Description: This family represents the ATP binding catalytic domain of the mRNA capping enzyme.
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Ontology Term
Pfam:PF03919 | mRNA capping enzyme, C-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR10556 | 3-OXO-5-ALPHA-STEROID 4-DEHYDROGENASE
 
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Ontology Term
PANTHER:PTHR10556:SF2 | STEROID 5-ALPHA-REDUCTASE DET2
 
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Ontology Term
Pfam:PF02544 | 3-oxo-5-alpha-steroid 4-dehydrogenase
Description: This family consists of 3-oxo-5-alpha-steroid 4-dehydrogenases, EC:1.3.99.5 Also known as Steroid 5-alpha-reductase, the reaction catalysed by this enzyme is: 3-oxo-5-alpha-steroid + acceptor <=> 3-oxo-delta(4)-steroid + reduced acceptor. The Steroid 5-alpha-reductase enzyme is responsible for the formation of dihydrotestosterone, this hormone promotes the differentiation of male external genitalia and the prostate during fetal development [2]. In humans mutations in this enzyme can cause a form of male pseudohermaphorditism in which the external genitalia and prostate fail to develop normally [2]. A related enzyme is also found in plants is Swiss:Q38944 (DET2) a steroid reductase from Arabidopsis. Mutations in this enzyme cause defects in light-regulated development [1].
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Ontology Term
PANTHER:PTHR22855 | ACETYL, PROPIONYL, PYRUVATE, AND GLUTACONYL CARBOXYLASE-RELATED
 
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Ontology Term
Pfam:PF03255 | Acetyl co-enzyme A carboxylase carboxyltransferase alpha subunit
Description: Acetyl co-enzyme A carboxylase carboxyltransferase is composed of an alpha and beta subunit.
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Ontology Term
PANTHER:PTHR13480 | E3 UBIQUITIN-PROTEIN LIGASE HAKAI-RELATED
 
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Ontology Term
PANTHER:PTHR13480:SF0 | E3 UBIQUITIN-PROTEIN LIGASE HAKAI
 
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Ontology Term
Pfam:PF05056 | Protein of unknown function (DUF674)
Description: This family is found in Arabidopsis thaliana and contains several uncharacterised proteins.
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Ontology Term
PANTHER:PTHR13384 | G PATCH DOMAIN-CONTAINING PROTEIN 1
 
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Ontology Term
Pfam:PF00244 | 14-3-3 protein
Description: NULL
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