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Category: OntologyTerm
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Type Details Score
Ontology Term
PANTHER:PTHR22931:SF9 | PYRUVATE, PHOSPHATE DIKINASE 1, CHLOROPLASTIC
 
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Ontology Term
Pfam:PF01326 | Pyruvate phosphate dikinase, AMP/ATP-binding domain
Description: This enzyme catalyses the reversible conversion of ATP to AMP, pyrophosphate and phosphoenolpyruvate (PEP). The N-terminal domain has been shown to be the AMP/ATP-binding domain [1].
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Ontology Term
Pfam:PF02896 | PEP-utilising enzyme, PEP-binding domain
Description: This entry represents a TIM barrel domain found at the C terminus of a number of PEP (phosphoenolpyruvate)-utilising proteins. In PPDK (Pyruvate phosphate dikinase) this C-terminal domain has been shown to be a PEP-binding domain [1].
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Ontology Term
PANTHER:PTHR11570 | S-ADENOSYLMETHIONINE DECARBOXYLASE
 
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Ontology Term
PANTHER:PTHR11570:SF0 | S-ADENOSYLMETHIONINE DECARBOXYLASE PROENZYME
 
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Ontology Term
Pfam:PF01536 | Adenosylmethionine decarboxylase
Description: This is a family of S-adenosylmethionine decarboxylase (SAMDC) proenzymes. In the biosynthesis of polyamines SAMDC produces decarboxylated S-adenosylmethionine, which serves as the aminopropyl moiety necessary for spermidine and spermine biosynthesis from putrescine [1]. The Pfam alignment contains both the alpha and beta chains that are cleaved to form the active enzyme.
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Ontology Term
PANTHER:PTHR23125:SF102 | F-BOX/LRR-REPEAT PROTEIN 4
 
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Ontology Term
PANTHER:PTHR23409 | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE SMALL CHAIN
 
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Ontology Term
Pfam:PF00268 | Ribonucleotide reductase, small chain
Description: NULL
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Ontology Term
PANTHER:PTHR31591 | UPF0613 PROTEIN PB24D3.06C
 
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Ontology Term
PANTHER:PTHR31591:SF1 | UPF0613 PROTEIN PB24D3.06C
 
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Ontology Term
Pfam:PF08538 | Protein of unknown function (DUF1749)
Description: This is a plant and fungal family of unknown function. This family contains many hypothetical proteins.
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Ontology Term
PANTHER:PTHR12677 | UNCHARACTERIZED
 
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Ontology Term
PANTHER:PTHR11772 | ASPARAGINE SYNTHETASE
 
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Ontology Term
PANTHER:PTHR12592 | ATP-DEPENDENT (S)-NAD(P)H-HYDRATE DEHYDRATASE FAMILY MEMBER
 
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Ontology Term
Pfam:PF01256 | Carbohydrate kinase
Description: This family is related to Pfam:PF02110 and Pfam:PF00294 implying that it also is a carbohydrate kinase. (personal obs Yeats C).
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Ontology Term
PANTHER:PTHR10953:SF6 | NEDD8-ACTIVATING ENZYME E1 CATALYTIC SUBUNIT
 
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Ontology Term
Pfam:PF08825 | E2 binding domain
Description: E1 and E2 enzymes play a central role in ubiquitin and ubiquitin-like protein transfer cascades. This is an E2 binding domain that is found on NEDD8 activating E1 enzyme. The domain resembles ubiquitin, and recruits the catalytic core of the E2 enzyme Ubc12 in a similar manner to that in which ubiquitin interacts with ubiquitin binding domains [1].
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Ontology Term
Pfam:PF10585 | Ubiquitin-activating enzyme, SCCH domain
Description: Ubiquitin-activating enzyme (E1 enzyme) activates ubiquitin by first adenylating with ATP its C-terminal glycine residue and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester and free AMP. Later the ubiquitin moiety is transferred to a cysteine residue on one of the many forms of ubiquitin-conjugating enzymes (E2) [1]. This domain carries the last of five conserved cysteines that is part of the active site of the enzyme, responsible for ubiquitin thiolester complex formation, the active site being represented by the sequence motif PICTLKNFP [2,3,4]. The catalytic cysteine domain contains the E1 active site cysteine, and is divided in two half-domains, FCCH and SCCH, for 'first' and 'second' catalytic cysteine half-domain, respectively. This is the SCCH domain in which resides the catalytic cysteine [5].
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Ontology Term
PANTHER:PTHR14269 | CDP-DIACYLGLYCEROL--GLYCEROL-3-PHOSPHATE 3-PHOSPHATIDYLTRANSFERASE-RELATED
 
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Ontology Term
Pfam:PF01066 | CDP-alcohol phosphatidyltransferase
Description: All of these members have the ability to catalyse the displacement of CMP from a CDP-alcohol by a second alcohol with formation of a phosphodiester bond and concomitant breaking of a phosphoride anhydride bond.
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Ontology Term
Pfam:PF02676 | Methyltransferase TYW3
Description: The methyltransferase TYW3 (tRNA-yW- synthesising protein 3) has been identified in yeast to be involved in wybutosine (yW) biosynthesis [1]. yW is a complexly modified guanosine residue that contains a tricyclic base and is found at the 3' position adjacent the anticodon of phenylalanine tRNA. TYW3 is an N-4 methylase that methylates yW-86 to yield yW-72 in an Ado-Met-dependent manner [1].
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Ontology Term
PANTHER:PTHR11214:SF5 | HEXOSYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR23271 | HEPATOCELLULAR CARCINOMA-ASSOCIATED ANTIGEN 66
 
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Ontology Term
PANTHER:PTHR23271:SF1 | U3 SMALL NUCLEOLAR RNA-ASSOCIATED PROTEIN 6 HOMOLOG
 
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Ontology Term
Pfam:PF08640 | U3 small nucleolar RNA-associated protein 6
Description: This is a family of U3 nucleolar RNA-associated proteins which are involved in nucleolar processing of pre-18S ribosomal RNA [1].
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Ontology Term
PANTHER:PTHR13847:SF5 | AMINOMETHYLTRANSFERASE, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF14476 | Petal formation-expressed
Description: The members of this plant family from Arabidopsis thaliana appear to be proteins found in the chloroplast, expressed in the pollen tube during the petal differentiation and expansion stage. The function is not known.
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Ontology Term
Pfam:PF04885 | Stigma-specific protein, Stig1
Description: This family represents the Stig1 cysteine rich plant protein. The STIG1 gene is developmentally regulated and expressed specifically in the stigmatic secretory zone [1].
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Ontology Term
PANTHER:PTHR11946:SF7 | LEUCINE--TRNA LIGASE, MITOCHONDRIAL-RELATED
 
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Ontology Term
Pfam:PF13603 | Leucyl-tRNA synthetase, Domain 2
Description: This is a family of the conserved region of Leucine-tRNA ligase or Leucyl-tRNA synthetase, EC:6.1.1.4.
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Ontology Term
PANTHER:PTHR31126 | TYROSINE-PROTEIN PHOSPHATASE
 
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Ontology Term
PANTHER:PTHR31126:SF0 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR11216:SF31 | AT21416P
 
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Ontology Term
Pfam:PF07734 | F-box associated
Description: Most of these proteins contain Pfam:PF00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.
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Ontology Term
PANTHER:PTHR20854:SF4 | INOSITOL-1-MONOPHOSPHATASE-RELATED
 
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Ontology Term
Pfam:PF04526 | Protein of unknown function (DUF568)
Description: Family of uncharacterised plant proteins.
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Ontology Term
PANTHER:PTHR11615:SF31 | CYTOSOLIC FE-S CLUSTER ASSEMBLY FACTOR CG17683-RELATED
 
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Ontology Term
Pfam:PF02256 | Iron hydrogenase small subunit
Description: This family represents the small subunit of the Fe-only hydrogenases EC:1.18.99.1. The subunit is comprised of alternating random coil and alpha helical structures that encompasses the large subunit in a novel protein fold [1].
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Ontology Term
Pfam:PF02906 | Iron only hydrogenase large subunit, C-terminal domain
Description: NULL
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Ontology Term
Pfam:PF05421 | Protein of unknown function (DUF751)
Description: This family contains several plant, cyanobacterial and algal proteins of unknown function. The family is exclusively found in phototrophic organisms and may therefore play a role in photosynthesis (personal obs:Moxon SJ).
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Ontology Term
PANTHER:PTHR22601:SF0 | OLIGOPEPTIDE TRANSPORTER 7
 
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Ontology Term
PANTHER:PTHR10343 | 5'-AMP-ACTIVATED PROTEIN KINASE , BETA SUBUNIT
 
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Ontology Term
PANTHER:PTHR10343:SF40 | SNF1-RELATED PROTEIN KINASE REGULATORY SUBUNIT BETA-2
 
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Ontology Term
Pfam:PF04739 | 5'-AMP-activated protein kinase beta subunit, interaction domain
Description: This region is found in the beta subunit of the 5'-AMP-activated protein kinase complex, and its yeast homologues Sip1, Sip2 and Gal83, which are found in the SNF1 kinase complex [1]. This region is sufficient for interaction of this subunit with the kinase complex, but is not solely responsible for the interaction, and the interaction partner is not known [2]. The isoamylase N-terminal domain (Pfam:PF02922) is sometimes found in proteins belonging to this family.
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Ontology Term
PANTHER:PTHR18919 | ACETYL-COA C-ACYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR24031:SF23 | ATP-DEPENDENT RNA HELICASE DDX23-RELATED
 
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Ontology Term
PANTHER:PTHR16122 | MCTP-RELATED
 
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Ontology Term
PANTHER:PTHR13421 | SNRNA-ACTIVATING PROTEIN COMPLEX SUBUNIT 3
 
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Ontology Term
Pfam:PF12251 | snRNA-activating protein complex (SNAPc), subunit 3
Description: This entry represents the C-terminal part of the SNAPC3 protein found in eukaryotes. This protein is part of the snRNA-activating protein complex which activates RNA polymerases II and III. There is a cysteine-histidine cluster which contains two possible zinc finger motifs.
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Ontology Term
Pfam:PF05991 | YacP-like NYN domain
Description: This family consists of bacterial proteins related to YacP. This family is uncharacterised functionally, but it has been suggested that these proteins are nucleases due to them containing a NYN domain. NYN (for N4BP1, YacP-like Nuclease) domains were discovered by Anantharaman and Aravind [1]. Based on gene neighborhoods it was suggested that the bacterial YacP proteins interact with the Ribonuclease III and TrmH methylase in a processome complex that catalyzes the maturation of rRNA and tRNA [1].
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Ontology Term
Pfam:PF14714 | KH-domain-like of EngA bacterial GTPase enzymes, C-terminal
Description: The KH-like domain at the C-terminus of the EngA subfamily of essential bacterial GTPases has a unique domain structure position. The two adjacent GTPase domains (GD1 and GD2), two domains of family MMR_HSR1, Pfam:PF01926, pack at either side of the C-terminal domain. This C-terminal domain resembles a KH domain but is missing the distinctive RNA recognition elements. Conserved motifs of the nucleotide binding site of GD1 are integral parts of the GD1-KH domain interface, suggesting the interactions between these two domains are directly influenced by the GTP/GDP cycling of the protein. In contrast, the GD2-KH domain interface is distal to the GDP binding site of GD2. This family has not been added to the KH clan since SCOP classifies it separately due to its missing the key KH motif/fold.
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Ontology Term
Pfam:PF12169 | DNA polymerase III subunits gamma and tau domain III
Description: This domain family is found in bacteria, and is approximately 110 amino acids in length. The family is found in association with Pfam:PF00004. Domains I-III are shared between the tau and the gamma subunits, while most of the DnaB-binding Domain IV and all of the alpha-interacting Domain V are unique to tau.
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Ontology Term
PANTHER:PTHR12696 | TIP120
 
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Ontology Term
PANTHER:PTHR12696:SF0 | CULLIN-ASSOCIATED NEDD8-DISSOCIATED PROTEIN 1
 
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Ontology Term
Pfam:PF08623 | TATA-binding protein interacting (TIP20)
Description: TIP120 (also known as cullin-associated and neddylation-dissociated protein 1) is a TATA binding protein interacting protein that enhances transcription [1].
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Ontology Term
PANTHER:PTHR12664 | SURVIVAL MOTOR NEURON PROTEIN
 
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Ontology Term
PANTHER:PTHR23168 | MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1 MITOTIC ARREST DEFICIENT-LIKE PROTEIN 1
 
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Ontology Term
PANTHER:PTHR23168:SF0 | MITOTIC SPINDLE ASSEMBLY CHECKPOINT PROTEIN MAD1
 
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Ontology Term
Pfam:PF05557 | Mitotic checkpoint protein
Description: This family consists of several eukaryotic mitotic checkpoint (Mitotic arrest deficient or MAD) proteins. The mitotic spindle checkpoint monitors proper attachment of the bipolar spindle to the kinetochores of aligned sister chromatids and causes a cell cycle arrest in prometaphase when failures occur. Multiple components of the mitotic spindle checkpoint have been identified in yeast and higher eukaryotes. In S.cerevisiae, the existence of a Mad1-dependent complex containing Mad2, Mad3, Bub3 and Cdc20 has been demonstrated [1].
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Ontology Term
Pfam:PF04339 | Peptidogalycan biosysnthesis/recognition
Description: FemAB_like is a family of both baterial and Viridiplantae proteins with responsibility for building interpeptide bridges in peptidoglycan. Such a function is feasible for bacteria but less likely for the plant members of this family. Perhaps the plant-members are using homologous proteins to recognise bacterial peptidoglcans as part of their innate immune system [1].
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Ontology Term
PANTHER:PTHR12654 | BILE ACID BETA-GLUCOSIDASE-RELATED
 
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Ontology Term
PANTHER:PTHR12654:SF0 | NON-LYSOSOMAL GLUCOSYLCERAMIDASE
 
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Ontology Term
Pfam:PF04685 | Glycosyl-hydrolase family 116, catalytic region
Description: This represents a family of archaeal, bacterial and eukaryotic glycosyl hydrolases, that belong to superfamily GH116. The primary catabolic pathway for glucosylceramide is catalysis by the lysosomal enzyme glucocerebrosidase. In higher eukaryotes, glucosylceramide is the precursor of glycosphingolipids, a complex group of ubiquitous membrane lipids [1]. Mutations in the human protein cause motor-neurone defects in hereditary spastic paraplegia [3]. The catalytic nucleophile, identified in UniProtKB:Q97YG8_SULSO, is a glutamine-335, with the likely acid/base at Asp-442 and the aspartates at Asp-406 and Asp-458 residues also playing a role in the catalysis of glucosides and xylosides that are beta-bound to hydrophobic groups. The family is defined as GH116, which presently includes enzymes with beta-glucosidase, EC:3.2.1.21, beta-xylosidase, EC:3.2.1.37, and glucocerebrosidase EC:3.2.1.45 activity [1,2].
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Ontology Term
Pfam:PF12215 | beta-glucosidase 2, glycosyl-hydrolase family 116 N-term
Description: This domain is found in bacteria, archaea and eukaryotes. This domain is typically between 320 to 354 amino acids in length. This domain is found associated with Pfam:PF04685. It is found just after the extreme N terminus. The N-terminal is thought to be the luminal domain while the C terminal is the cytosolic domain. The catalytic domain of GBA-2 is unknown. The primary catabolic pathway for glucosylceramide is catalysis by the lysosomal enzyme glucocerebrosidase. In higher eukaryotes, glucosylceramide is the precursor of glycosphingolipids, a complex group of ubiquitous membrane lipids [1]. Mutations in the human protein cause motor-neurone defects in hereditary spastic paraplegia [2,3]. The catalytic nucleophile, identified in UniProtKB:Q97YG8_SULSO, is a glutamine-335 in the downstream family Pfam:PF04685 [4].
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Ontology Term
Pfam:PF00647 | Elongation factor 1 gamma, conserved domain
Description: NULL
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Ontology Term
Pfam:PF02798 | Glutathione S-transferase, N-terminal domain
Description: Function: conjugation of reduced glutathione to a variety of targets. Also included in the alignment, but not GSTs: S-crystallins from squid (similarity to GST previously noted); eukaryotic elongation factors 1-gamma (not known to have GST activity and similarity not previously recognised); HSP26 family of stress-related proteins including auxin-regulated proteins in plants and stringent starvation proteins in E. coli (not known to have GST activity and similarity not previously recognised). The glutathione molecule binds in a cleft between the N- and C-terminal domains - the catalytically important residues are proposed to reside in the N-terminal domain [1].
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Ontology Term
PANTHER:PTHR10668:SF30 | FAD/NAD(P)-BINDING OXIDOREDUCTASE DOMAIN-CONTAINING PROTEIN
 
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Ontology Term
PANTHER:PTHR15590 | CX9C MOTIF-CONTAINING PROTEIN 4
 
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Ontology Term
PANTHER:PTHR15590:SF0 | CX9C MOTIF-CONTAINING PROTEIN 4
 
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Ontology Term
PANTHER:PTHR32183 | FAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR11200:SF24 | TYPE I INOSITOL 1,4,5-TRISPHOSPHATE 5-PHOSPHATASE 12-RELATED
 
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Ontology Term
PANTHER:PTHR12882 | SUPPRESSOR OF TY 4
 
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Ontology Term
Pfam:PF06093 | Spt4/RpoE2 zinc finger
Description: This family consists of several eukaryotic transcription elongation Spt4 proteins as well as archaebacterial RpoE2 [2]. Three transcription-elongation factors Spt4, Spt5, and Spt6 are conserved among eukaryotes and are essential for transcription via the modulation of chromatin structure. Spt4 and Spt5 are tightly associated in a complex, while the physical association of the Spt4-Spt5 complex with Spt6 is considerably weaker. It has been demonstrated that Spt4, Spt5, and Spt6 play roles in transcription elongation in both yeast and humans including a role in activation by Tat. It is known that Spt4, Spt5, and Spt6 are general transcription-elongation factors, controlling transcription both positively and negatively in important regulatory and developmental roles [1]. RpoE2 is one of 13 subunits in the archaeal RNA polymerase. These proteins contain a C4-type zinc finger, and the structure has been solved in [3]. The structure reveals that Spt4-Spt5 binding is governed by an acid-dipole interaction between Spt5 and Spt4, and the complex binds to and travels along the elongating RNA polymerase. The Spt4-Spt5 complex is likely to be an ancient, core component of the transcription elongation machinery.
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Ontology Term
PANTHER:PTHR14194 | NITROGEN METABOLIC REGULATION PROTEIN NMR-RELATED
 
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Ontology Term
Pfam:PF02272 | DHHA1 domain
Description: This domain is often found adjacent to the DHH domain Pfam:PF01368 and is called DHHA1 for DHH associated domain. This domain is diagnostic of DHH subfamily 1 members [1]. This domains is also found in alanyl tRNA synthetase e.g. Swiss:P00957, suggesting that this domain may have an RNA binding function. The domain is about 60 residues long and contains a conserved GG motif.
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Ontology Term
PANTHER:PTHR11952:SF1 | UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
 
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Ontology Term
PANTHER:PTHR12040:SF0 | HISTONE CHAPERONE ASF1
 
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Ontology Term
Pfam:PF14766 | Replication protein A interacting N-terminal
Description: This family of proteins represents the N-terminal domain of replication protein A (RPA) interacting protein. RPA interacting protein is involved in the import of RPA into the nucleus. The N-terminal domain is responsible for interaction with importin beta [1-2].
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Ontology Term
Pfam:PF07786 | Heparan-alpha-glucosaminide N-acetyltransferase, catalytic
Description: This entry includes the catalytic domain of HGSNAT (Heparan-alpha-glucosaminide N-acetyltransferase). It contains the conserved histidine in the active site (His269), thought to hold the acetyl group during the transfer across the membrane and required for its enzymatic activity. HGSNAT transfers an acetyl group from cytoplasmically derived acetyl-CoA to terminal N-glucosamine residues of heparan sulfate within the lysosomes [1].
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Ontology Term
PANTHER:PTHR13593 | UNCHARACTERIZED
 
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Ontology Term
Pfam:PF00304 | Gamma-thionin family
Description: NULL
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Ontology Term
PANTHER:PTHR11096 | RNA 3' TERMINAL PHOSPHATE CYCLASE
 
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Ontology Term
PANTHER:PTHR11096:SF0 | RNA 3'-TERMINAL PHOSPHATE CYCLASE
 
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Ontology Term
Pfam:PF01137 | RNA 3'-terminal phosphate cyclase
Description: RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].
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Ontology Term
Pfam:PF05189 | RNA 3'-terminal phosphate cyclase (RTC), insert domain
Description: RNA cyclases are a family of RNA-modifying enzymes that are conserved in all cellular organisms. They catalyse the ATP-dependent conversion of the 3'-phosphate to the 2',3'-cyclic phosphodiester at the end of RNA, in a reaction involving formation of the covalent AMP-cyclase intermediate [1]. The structure of RTC demonstrates that RTCs are comprised two domain. The larger domain contains an insert domain of approximately 100 amino acids [1].
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Ontology Term
PANTHER:PTHR13255 | ATAXIN-10
 
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Ontology Term
Pfam:PF09759 | Spinocerebellar ataxia type 10 protein domain
Description: This is the conserved C-terminal 100 residues of Ataxin-10. Ataxin-10 belongs to the family of armadillo repeat proteins and in solution it tends to form homotrimeric complexes, which associate via a tip-to-tip association in a horseshoe-shaped contact with the concave sides of the molecules facing each other. This domain may represent the homo-association site since that is located near the C-terminus of Ataxin-10. The protein does not contain a signal sequence for secretion or any subcellular compartment confirming its cytoplasmic localisation, specifically to the olivocerebellar region [1].
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Ontology Term
Pfam:PF12349 | Sterol-sensing domain of SREBP cleavage-activation
Description: Sterol regulatory element-binding proteins (SREBPs) are membrane-bound transcription factors that promote lipid synthesis in animal cells. They are embedded in the membranes of the endoplasmic reticulum (ER) in a helical hairpin orientation and are released from the ER by a two-step proteolytic process. Proteolysis begins when the SREBPs are cleaved at Site-1, which is located at a leucine residue in the middle of the hydrophobic loop in the lumen of the ER [1]. Upon proteolytic processing SREBP can activate the expression of genes involved in cholesterol biosynthesis and uptake. SCAP stimulates cleavage of SREBPs via fusion of the their two C-termini [2]. This domain is the transmembrane region that traverses the membrane eight times and is the sterol-sensing domain of the cleavage protein [4]. WD40 domains are found towards the C-terminus.
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Ontology Term
PANTHER:PTHR12858 | RIBOSOME BIOGENESIS PROTEIN
 
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Ontology Term
PANTHER:PTHR12858:SF1 | PRE-RRNA-PROCESSING PROTEIN TSR1 HOMOLOG
 
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Ontology Term
Pfam:PF04950 | 40S ribosome biogenesis protein Tsr1 and BMS1 C-terminal
Description: RIBIOP_C is a family of eukaryotic proteins from the C-terminus of pre-rRNA-processing protein or ribosome biogenesis proteins BMS1 and TSR1. These proteins act, in the nucleolus, as a molecular switch during maturation of the 40S ribosomal subunit [1,2]. This domain, domain IV of translation elongation factor selb, adopts the same fold as translation proteins such as domain II of GTP-elongation factor Tu proteins [3].
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Ontology Term
Pfam:PF08142 | AARP2CN (NUC121) domain
Description: This domain is the central domain of AARP2. It is weakly similar to the GTP-binding domain of elongation factor TU [1].
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Ontology Term
PANTHER:PTHR23038 | THYMIC STROMAL COTRANSPORTER-RELATED
 
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Ontology Term
PANTHER:PTHR13651:SF0 | PROTEIN ABITRAM
 
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Ontology Term
Pfam:PF15365 | Proline-rich nuclear receptor coactivator motif
Description: The PNRC family, proline-rich nuclear receptor coactivator, is found in eukaryotes. Studies in S. pombe show that the proteins carrying this motif are mRNA decapping proteins. In addition, this motif is found in Saccharomyces cerevisiae two intrinsically disordered decapping enhancers Edc1 and Edc2, which show limited sequence conservation with human PNRC2. This motif in the N-terminal domain serves two purposes: it enhances the activity of the catalytic domain by recognizing part of the mRNA cap structure (i.e. activation motif) , and secondly, it directly interacts with the decapping activator Dcp1. Mutation in the (YAG) sequence led to los of activity of activate the decapping complex. Hence the activity of the family members involved in mRNA processing mechanisms depends on YAG activation motif that is 11-13 residues N-terminal of a conserved LPxP Dcp1 interaction motif [2].
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Ontology Term
PANTHER:PTHR24115:SF87 | KINESIN-LIKE PROTEIN KIF15
 
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Ontology Term
PANTHER:PTHR17920:SF3 | TRANSMEMBRANE AND COILED-COIL DOMAIN-CONTAINING PROTEIN 4
 
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Ontology Term
PANTHER:PTHR10445:SF0 | GENERAL TRANSCRIPTION FACTOR IIF SUBUNIT 2
 
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Ontology Term
Pfam:PF00396 | Granulin
Description: NULL
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USDA
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