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Category: OntologyTerm
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Type Details Score
Ontology Term
Pfam:PF00238 | Ribosomal protein L14p/L23e
Description: NULL
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Ontology Term
Pfam:PF00252 | Ribosomal protein L16p/L10e
Description: NULL
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Ontology Term
PANTHER:PTHR31344 | NUCLEAR PORE COMPLEX PROTEIN NUP205
 
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Ontology Term
PANTHER:PTHR31344:SF0 | NUCLEAR PORE COMPLEX PROTEIN NUP205
 
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Ontology Term
Pfam:PF11894 | Nuclear pore complex scaffold, nucleoporins 186/192/205
Description: This is a family of eukaryotic nucleoporins of several different sizes. All of them are long and form the scaffold of the nuclear pore complex. Nup192 in particular modulates the permeability of the central channel of the NPC central or nuclear pore complex [1].
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Ontology Term
Pfam:PF10559 | Plug domain of Sec61p
Description: The Sec61/SecY translocon mediates translocation of proteins across the membrane and integration of membrane proteins into the lipid bilayer. The structure of the translocon revealed a plug domain blocking the pore on the lumenal side.The plug is unlikely to be important for sealing the translocation pore in yeast but it plays a role in stabilising Sec61p during translocon formation. The domain runs from residues 52-74 [1].
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Ontology Term
Pfam:PF04515 | Plasma-membrane choline transporter
Description: This family represents a high-affinity plasma-membrane choline transporter in C.elegans which is thought to be rate-limiting for ACh synthesis in cholinergic nerve terminals [1].
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Ontology Term
PANTHER:PTHR24015:SF172 | SUBFAMILY NOT NAMED
 
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Ontology Term
Pfam:PF06838 | Methionine gamma-lyase
Description: This is a putative pyridoxal 5'-phosphate-dependent methionine gamma-lyase enzyme involved in methionine catabolism.
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Ontology Term
PANTHER:PTHR31272 | CYTOCHROME C-TYPE BIOGENESIS PROTEIN HI_1454-RELATED
 
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Ontology Term
Pfam:PF02683 | Cytochrome C biogenesis protein transmembrane region
Description: This family consists of the transmembrane (i.e. non-catalytic) region of Cytochrome C biogenesis proteins also known as disulphide interchange proteins. These proteins posses a protein disulphide isomerase like domain that is not found within the aligned region of this family.
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Ontology Term
PANTHER:PTHR11599:SF11 | PROTEASOME SUBUNIT ALPHA TYPE-6
 
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Ontology Term
PANTHER:PTHR24006:SF149 | BCDNA.LD22910
 
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Ontology Term
PANTHER:PTHR31966 | OS01G0783500 PROTEIN
 
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Ontology Term
PANTHER:PTHR19139:SF55 | AQUAPORIN TIP1-3
 
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Ontology Term
PANTHER:PTHR12895 | DYMECLIN
 
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Ontology Term
Pfam:PF02268 | Transcription initiation factor IIA, gamma subunit, helical domain
Description: Accurate transcription in vivo requires at least six general transcription initiation factors, in addition to RNA polymerase II. Transcription initiation factor IIA (TFIIA) is a multimeric protein which facilitates the binding of TFIID to the TATA box. The N-terminal domain of the gamma subunit is a 4 helix bundle.
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Ontology Term
PANTHER:PTHR11879:SF0 | ASPARTATE AMINOTRANSFERASE, MITOCHONDRIAL
 
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Ontology Term
Pfam:PF07420 | Protein of unknown function (DUF1509)
Description: This family consists of several uncharacterised viral proteins from the Marek's disease-like viruses. Members of this family are typically around 400 residues in length. The function of this family is unknown.
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Ontology Term
PANTHER:PTHR11240 | RIBONUCLEASE T2
 
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Ontology Term
PANTHER:PTHR31435 | PROTEIN NATD1
 
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Ontology Term
PANTHER:PTHR31435:SF1 | PROTEIN C17ORF103
 
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Ontology Term
Pfam:PF14542 | GCN5-related N-acetyl-transferase
Description: This family of GCN5-related N-acetyl-transferases bind both CoA and acetyl-CoA. They are characterised by highly conserved glycine, a cysteine residue in the acetyl-CoA binding site near the acetyl group, their small size compared with other GNATs and a lack of of an obvious substrate-binding site. It is proposed that they transfer an acetyl group from acetyl-CoA to one or more unidentified aliphatic amines via an acetyl (cysteine) enzyme intermediate. The substrate might be another macromolecule.
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Ontology Term
PANTHER:PTHR31045 | PLAC8 FAMILY PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR20836 | DIHYDRODIPICOLINATE REDUCTASE
 
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Ontology Term
Pfam:PF07111 | Alpha helical coiled-coil rod protein (HCR)
Description: This family consists of several mammalian alpha helical coiled-coil rod HCR proteins. The function of HCR is unknown but it has been implicated in psoriasis in humans and is thought to affect keratinocyte proliferation [1].
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Ontology Term
PANTHER:PTHR23042:SF25 | TRANSCRIPTION FACTOR BHLH125-RELATED
 
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Ontology Term
PANTHER:PTHR15565 | AATF PROTEIN APOPTOSIS ANTAGONIZING TRANSCRIPTION FACTOR
 
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Ontology Term
PANTHER:PTHR15565:SF0 | PROTEIN AATF
 
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Ontology Term
Pfam:PF08164 | Apoptosis-antagonizing transcription factor, C-terminal
Description: This C terminal domain is found in traube proteins [1]. This is the domain of the AATF proteins that interacts with BLOS2 or Ceap, that functions as an adaptor in processes such as protein and vesicle processing and transport, and perhaps transcription.
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Ontology Term
PANTHER:PTHR13048 | TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT 3
 
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Ontology Term
PANTHER:PTHR13048:SF0 | TRAFFICKING PROTEIN PARTICLE COMPLEX SUBUNIT
 
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Ontology Term
PANTHER:PTHR10388 | EUKARYOTIC TRANSLATION INITIATION FACTOR SUI1
 
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Ontology Term
Pfam:PF07970 | Endoplasmic reticulum vesicle transporter
Description: This family is conserved from plants and fungi to humans. Erv46 works in close conjunction with Erv41 and together they form a complex which cycles between the endoplasmic reticulum and Golgi complex. Erv46-41 interacts strongly with the endoplasmic reticulum glucosidase II. Mammalian glucosidase II comprises a catalytic alpha-subunit and a 58 kDa beta subunit, which is required for ER localisation. All proteins identified biochemically as Erv41p-Erv46p interactors are localised to the early secretory pathway and are involved in protein maturation and processing in the ER and/or sorting into COPII vesicles for transport to the Golgi [3].
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Ontology Term
Pfam:PF00766 | Electron transfer flavoprotein FAD-binding domain
Description: This domain found at the C-terminus of electron transfer flavoprotein alpha chain and binds to FAD [1]. The fold consists of a five-stranded parallel beta sheet as the core of the domain, flanked by alternating helices. A small part of this domain is donated by the beta chain [1].
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Ontology Term
Pfam:PF01012 | Electron transfer flavoprotein domain
Description: This family includes the homologous domain shared between the alpha and beta subunits of the electron transfer flavoprotein [1].
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Ontology Term
Pfam:PF06764 | Protein of unknown function (DUF1223)
Description: This family consists of several hypothetical proteins of around 250 residues in length which are found in both plants and bacteria. The function of this family is unknown. Structurally it lies in the Thioredoxin-like superfamily.
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Ontology Term
PANTHER:PTHR31064 | POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED
 
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Ontology Term
PANTHER:PTHR31064:SF1 | POTASSIUM TRANSPORT PROTEIN DDB_G0292412-RELATED
 
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Ontology Term
Pfam:PF02386 | Cation transport protein
Description: This family consists of various cation transport proteins (Trk) and V-type sodium ATP synthase subunit J or translocating ATPase J EC:3.6.1.34. These proteins are involved in active sodium up-take utilising ATP in the process. TrkH a member of the family Swiss:P76769 from E. coli is a hydrophobic membrane protein and determines the specificity and kinetics of cation transport by the TrK system in E. coli [2].
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Ontology Term
Pfam:PF14764 | AP-5 complex subunit, vesicle trafficking
Description: This family would appear to be the second of the two larger subunits of the fifth Adaptor-Protein complex, AP-5. Adaptor protein (AP) complexes facilitate the trafficking of cargo from one membrane compartment of the cell to another by recruiting other proteins to particular types of vesicles. AP-5 is involved in trafficking proteins from endosomes towards other membranous compartments [2]. There are genetic links between AP-5 and hereditary spastic paraplegia, a group of human genetic disorders characterised by progressive spasticity in the lower limbs [1].
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Ontology Term
Pfam:PF03024 | Folate receptor family
Description: This family includes the folate receptor which binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate to the interior of cells. These proteins are attached to the membrane by a GPI-anchor. The proteins contain 16 conserved cysteines that form eight disulphide bridges.
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Ontology Term
PANTHER:PTHR25040:SF110 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR10887:SF14 | PROTEIN DNA-2, ISOFORM A
 
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Ontology Term
PANTHER:PTHR23105:SF5 | RIBOSOMAL L1 DOMAIN-CONTAINING PROTEIN 1
 
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Ontology Term
PANTHER:PTHR10245 | ENDOTHELIAL DIFFERENTIATION-RELATED FACTOR 1 MULTIPROTEIN BRIDGING FACTOR 1
 
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Ontology Term
Pfam:PF01381 | Helix-turn-helix
Description: This large family of DNA binding helix-turn helix proteins includes Cro Swiss:P03036 and CI Swiss:P03034. Within the protein Swiss:Q5F9C2, the full protein fold incorporates a helix-turn-helix motif, but the function of this member is unlikely to be that of a DNA-binding regulator, the function of most other members, so is not necessarily characteristic of the whole family [1].
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Ontology Term
Pfam:PF08523 | Multiprotein bridging factor 1
Description: This domain is found in the multiprotein bridging factor 1 (MBF1) which forms a heterodimer with MBF2. It has been shown to make direct contact with the TATA-box binding protein (TBP) and interacts with Ftz-F1, stabilising the Ftz-F1-DNA complex [2]. It is also found in the endothelial differentiation-related factor (EDF-1). Human EDF-1 is involved in the repression of endothelial differentiation, interacts with CaM and is phosphorylated by PKC [1]. The domain is found in a wide range of eukaryotic proteins including metazoans, fungi and plants. A helix-turn-helix motif (Pfam:PF01381) is found to its C-terminus.
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Ontology Term
PANTHER:PTHR22966:SF0 | 2-AMINOETHANETHIOL DIOXYGENASE
 
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Ontology Term
PANTHER:PTHR30523:SF0 | PHOSPHOENOLPYRUVATE CARBOXYLASE 4
 
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Ontology Term
PANTHER:PTHR15439:SF0 | E3 UBIQUITIN-PROTEIN LIGASE RBBP6
 
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Ontology Term
PANTHER:PTHR10108:SF626 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR24015:SF53 | SUBFAMILY NOT NAMED
 
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Ontology Term
PANTHER:PTHR12630 | N-LINKED OLIGOSACCHARIDE PROCESSING
 
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Ontology Term
Pfam:PF12999 | Glucosidase II beta subunit-like
Description: The sequences found in this family are similar to a region found in the beta-subunit of glucosidase II (Swiss:P14314), which is also known as protein kinase C substrate 80K-H (PRKCSH). The enzyme catalyses the sequential removal of two alpha-1,3-linked glucose residues in the second step of N-linked oligosaccharide processing [1]. The beta subunit is required for the solubility and stability of the heterodimeric enzyme, and is involved in retaining the enzyme within the endoplasmic reticulum [1].
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Ontology Term
PANTHER:PTHR23115:SF14 | ELONGATION FACTOR FAMILY PROTEIN
 
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Ontology Term
PANTHER:PTHR12499 | OPTIC ATROPHY 3 PROTEIN OPA3
 
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Ontology Term
PANTHER:PTHR12499:SF0 | OPTIC ATROPHY 3 PROTEIN
 
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Ontology Term
Pfam:PF07047 | Optic atrophy 3 protein (OPA3)
Description: This family consists of several optic atrophy 3 (OPA3) proteins. OPA3 deficiency causes type III 3-methylglutaconic aciduria (MGA) in humans. This disease manifests with early bilateral optic atrophy, spasticity, extrapyramidal dysfunction, ataxia, and cognitive deficits, but normal longevity [1].
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Ontology Term
PANTHER:PTHR23405 | MAINTENANCE OF KILLER 16 MAK16 PROTEIN-RELATED
 
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Ontology Term
PANTHER:PTHR23405:SF4 | PROTEIN MAK16 HOMOLOG
 
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Ontology Term
Pfam:PF04874 | Mak16 protein C-terminal region
Description: The precise function of this eukaryotic protein family is unknown. The yeast orthologues have been implicated in cell cycle progression and biogenesis of 60S ribosomal subunits. The Schistosoma mansoni Mak16 has been shown to target protein transport to the nucleolus [1].
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Ontology Term
PANTHER:PTHR21368 | 50S RIBOSOMAL PROTEIN L9
 
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Ontology Term
Pfam:PF01281 | Ribosomal protein L9, N-terminal domain
Description: NULL
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Ontology Term
PANTHER:PTHR10943:SF1 | 26S PROTEASOME NON-ATPASE REGULATORY SUBUNIT 2
 
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Ontology Term
PANTHER:PTHR22726 | METALLOENDOPEPTIDASE OMA1
 
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Ontology Term
Pfam:PF01435 | Peptidase family M48
Description: Peptidase_M48 is the largely extracellular catalytic region of CAAX prenyl protease homologues such as Human FACE-1 protease. These are metallopeptidases, with the characteristic HExxH motif giving the two histidine-zinc-ligands and an adjacent glutamate on the next helix being the third. The whole molecule folds to form a deep groove/cleft into which the substrate can fit [1,2].
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Ontology Term
PANTHER:PTHR14030 | MITOTIC CHECKPOINT SERINE/THREONINE-PROTEIN KINASE BUB1
 
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Ontology Term
Pfam:PF08311 | Mad3/BUB1 homology region 1
Description: Proteins containing this domain are checkpoint proteins involved in cell division. This region has been shown to be essential for the binding of the binding of BUB1 and MAD3 to CDC20p [1].
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Ontology Term
PANTHER:PTHR15111 | RNA POLYMERASE II SUBUNIT 5-MEDIATING PROTEIN NNX3
 
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Ontology Term
PANTHER:PTHR15111:SF0 | UNCONVENTIONAL PREFOLDIN RPB5 INTERACTOR 1
 
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Ontology Term
PANTHER:PTHR13126 | CHAPERONE ATP11
 
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Ontology Term
PANTHER:PTHR13126:SF0 | ATP SYNTHASE MITOCHONDRIAL F1 COMPLEX ASSEMBLY FACTOR 1
 
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Ontology Term
Pfam:PF06644 | ATP11 protein
Description: This family consists of several eukaryotic ATP11 proteins. In Saccharomyces cerevisiae, expression of functional F1-ATPase requires two proteins encoded by the ATP11 and ATP12 genes [1]. Atp11p is a molecular chaperone of the mitochondrial matrix that participates in the biogenesis pathway to form F1, the catalytic unit of the ATP synthase [2].
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Ontology Term
PANTHER:PTHR21162 | P53 AND DNA DAMAGE-REGULATED PROTEIN
 
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Ontology Term
PANTHER:PTHR21162:SF0 | P53 AND DNA DAMAGE-REGULATED PROTEIN 1
 
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Ontology Term
Pfam:PF02517 | Type II CAAX prenyl endopeptidase Rce1-like
Description: This family (also known as the ABI (abortive infection) family) contains putative IMPs and has homologues in all three domains of life, including Rce1 from S. cerevisiae [1]. Rce1 is a type II CAAX prenyl protease that processes all farnesylated and geranylgeranylated CAAX proteins. It is an integral membrane endoprotease localized to the endoplasmic reticulum that mediates the cleavage of the carboxyl-terminal three amino acids from CaaX proteins. It is involved in processing the Ras family of small GTPases, the gamma-subunit of heterotrimeric GTPases, nuclear lamins, and protein kinases and phosphatases [2]. Three residues of S. cerevisiae Rce1 -E156, H194 and H248- are critical for catalysis [3]. The structure of Rce1 from the archaea Methanococcus (MmRce1) suggests that this group of proteins represents a novel IMP (intramembrane protease) family, the glutamate IMPs [4]. There is a conserved sequence motif EExxxR.
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Ontology Term
PANTHER:PTHR12736 | LANC-LIKE PROTEIN
 
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Ontology Term
Pfam:PF05147 | Lanthionine synthetase C-like protein
Description: Lanthionines are thioether bridges that are putatively generated by dehydration of Ser and Thr residues followed by addition of cysteine residues within the peptide. This family contains the lanthionine synthetase C-like proteins 1 and 2 which are related to the bacterial lanthionine synthetase components C (LanC). LANCL1 (P40 seven-transmembrane-domain protein) and LANCL2 (testes-specific adriamycin sensitivity protein) are thought to be peptide-modifying enzyme components in eukaryotic cells. Both proteins are produced in large quantities in the brain and testes and may have role in the immune surveillance of these organs [1]. Lanthionines are found in lantibiotics, which are peptide-derived, post-translationally modified antimicrobials produced by several bacterial strains [2]. This region contains seven internal repeats.
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Ontology Term
PANTHER:PTHR13832:SF193 | PROTEIN PHOSPHATASE 2C 1-RELATED
 
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Ontology Term
PANTHER:PTHR31633 | H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1
 
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Ontology Term
PANTHER:PTHR31633:SF1 | H/ACA RIBONUCLEOPROTEIN COMPLEX NON-CORE SUBUNIT NAF1
 
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Ontology Term
Pfam:PF04410 | Gar1/Naf1 RNA binding region
Description: Gar1 is a small nucleolar RNP that is required for pre-mRNA processing and pseudouridylation [1]. It is co-immunoprecipitated with the H/ACA families of snoRNAs. This family represents the conserved central region of Gar1. This region is necessary and sufficient for normal cell growth, and specifically binds two snoRNAs snR10 and snR30. This region is also necessary for nucleolar targeting, and it is thought that the protein is co-transported to the nucleolus as part of a nucleoprotein complex [2]. In humans, Gar1 is also component of telomerase in vivo [3]. Naf1 is an essential protein that plays a role in ribosome biogenesis, modification of spliceosomal small nuclear RNAs and telomere synthesis, and is homologous to Gar1 [4].
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Ontology Term
Pfam:PF12609 | Wound-induced protein
Description: This family of proteins is found in eukaryotes. Proteins in this family are typically between 81 and 97 amino acids in length. The proteins in the family are often annotated as wound-induced proteins however there is little accompanying literature to confirm this.
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Ontology Term
Pfam:PF11264 | Thylakoid formation protein
Description: THF1 is localised to the outer plastid membrane and the stroma. THF1 has a role in sugar signalling [1]. THF1 is also thought to have a role in chloroplast and leaf development. THF1 has been shown to play a crucial role in vesicle-mediated thylakoid membrane biogenesis [2].
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Ontology Term
PANTHER:PTHR10134 | CYTOCHROME B-C1 COMPLEX SUBUNIT RIESKE, MITOCHONDRIAL
 
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Ontology Term
PANTHER:PTHR31352:SF1 | BETA-AMYLASE 3, CHLOROPLASTIC
 
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Ontology Term
PANTHER:PTHR31225:SF0 | S-(+)-LINALOOL SYNTHASE, CHLOROPLASTIC
 
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Ontology Term
PANTHER:PTHR21530 | PHEROMONE SHUTDOWN PROTEIN
 
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Ontology Term
PANTHER:PTHR21631:SF3 | BIFUNCTIONAL GLYOXYLATE CYCLE PROTEIN
 
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Ontology Term
Pfam:PF00463 | Isocitrate lyase family
Description: NULL
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Ontology Term
PANTHER:PTHR11210 | RING BOX
 
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Ontology Term
PANTHER:PTHR11210:SF2 | E3 UBIQUITIN-PROTEIN LIGASE RBX1-RELATED
 
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Ontology Term
PANTHER:PTHR31204 | SIGMA INTRACELLULAR RECEPTOR 2
 
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Ontology Term
PANTHER:PTHR31204:SF1 | SIGMA INTRACELLULAR RECEPTOR 2
 
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Ontology Term
PANTHER:PTHR10978 | SUCCINATE DEHYDROGENASE CYTOCHROME B560 SUBUNIT
 
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Ontology Term
Pfam:PF01127 | Succinate dehydrogenase/Fumarate reductase transmembrane subunit
Description: This family includes a transmembrane protein from both the Succinate dehydrogenase and Fumarate reductase complexes.
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Ontology Term
PANTHER:PTHR10953:SF29 | NEDD8-ACTIVATING ENZYME E1 REGULATORY SUBUNIT
 
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Ontology Term
Pfam:PF00595 | PDZ domain
Description: PDZ domains are found in diverse signaling proteins.
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Ontology Term
Pfam:PF02163 | Peptidase family M50
Description: NULL
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