v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | The HhH-GPD superfamily gets its name from its hallmark helix-hairpin-helix and Gly/Pro rich loop followed by a conserved aspartate [ , ]. This domain is found in a diverse range of structurally related DNA repair proteins that include: endonuclease III, and DNA glycosylase MutY, an A/G-specific adenine glycosylase. Both of these enzymes have a C-terminal iron-sulphur cluster loop (FCL). The methyl-CPG binding protein (MBD4) also contain a related domain that is a thymine DNA glycosylase [ ]. The family also includes DNA-3-methyladenine glycosylase II , 8-oxoguanine DNA glycosylases and other members of the AlkA family. |
Short Name | HhH-GPD_domain |