Protein Domain : Malate dehydrogenase, active site IPR001252

Type  Active_site
Description  Malate dehydrogenase ( ) (MDH) [ ] catalyzes the interconversionof malate to oxaloacetate utilizing the NAD/NADH cofactor system. The enzyme participates in the citric acid cycle and exists in all aerobics organisms.While prokaryotic organisms contains a single form of MDH, in eukaryotic cells there are two isozymes: one which is located in the mitochondrial matrix andthe other in the cytoplasm. Fungi and plants also harbor a glyoxysomal form which functions in the glyoxylate pathway. In plants chloroplast there is anadditional NADP-dependent form of MDH ( ) which is essential for both the universal C3 photosynthesis (Calvin) cycle and the more specialisedC4 cycle. The pattern for this enzyme includes two residues involved in the catalytic mechanism []: an aspartic acid whichis involved in a proton relay mechanism, and an arginine which binds the substrate.
Short Name  Malate_DH_AS

0 Child Features

0 Gene Families

730 Genes

2 Ontology Annotations

0 Parent Features

13 Publications

USDA
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