v5.1.0.3
Glycine data from LIS
Type | Active_site |
Description | Malate dehydrogenase ( ) (MDH) [ ] catalyzes the interconversionof malate to oxaloacetate utilizing the NAD/NADH cofactor system. The enzyme participates in the citric acid cycle and exists in all aerobics organisms.While prokaryotic organisms contains a single form of MDH, in eukaryotic cells there are two isozymes: one which is located in the mitochondrial matrix andthe other in the cytoplasm. Fungi and plants also harbor a glyoxysomal form which functions in the glyoxylate pathway. In plants chloroplast there is anadditional NADP-dependent form of MDH ( ) which is essential for both the universal C3 photosynthesis (Calvin) cycle and the more specialisedC4 cycle. The pattern for this enzyme includes two residues involved in the catalytic mechanism []: an aspartic acid whichis involved in a proton relay mechanism, and an arginine which binds the substrate. |
Short Name | Malate_DH_AS |