Protein Domain : Chromatin assembly factor 1 subunit A IPR022043

Type  Family
Description  The CAF-1 or chromatin assembly factor-1 consists of three subunits, and this is the first, or A [ ]. The A domain is uniquely required for the progression of S phase in mouse cells [], independent of its ability to promote histone deposition [] but dependent on its ability to interact with HP1 - heterochromatin protein 1-rich heterochromatin domains next to centromeres that are crucial for chromosome segregation during mitosis. This HP1-CAF-1 interaction module functions as a built-in replication control for heterochromatin, which, like a control barrier, has an impact on S-phase progression in addition to DNA-based checkpoints [].
Short Name  CAF1A

0 Child Features

1 Gene Families

112 Genes

0 Ontology Annotations

0 Parent Features

13 Publications

USDA
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