Protein Domain : Uroporphyrinogen decarboxylase HemE IPR006361

Type  Family
Description  This entry represents uroporphyrinogen decarboxylase (URO-D or HemE), which catalyzes the fifth step in the haem biosynthetic pathway, converting uroporphyrinogen III to coproporphyrinogen III by decarboxylating the four acetate side chains of the substrate [ ]. This step takes the pathway toward protoporphyrin IX, a common precursor of both haem and chlorophyll, rather than toward precorrin 2 and its products.This activity is essential in all organisms, and subnormal activity of URO-D leads to the most common form of porphyria in humans, porphyria cutanea tarda (PCT) as well as hepatoerythropoietic porphyria (HEP) [ ].
Short Name  Uroporphyrinogen_deCO2ase_HemE

0 Child Features

2 Gene Families

203 Genes

2 Ontology Annotations

0 Parent Features

14 Publications

USDA
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