Protein Domain : 26S proteasome non-ATPase regulatory subunit 5 IPR019538

Type  Family
Description  The 26S proteasome is an enzymatic complex that degrades ubiquitinated proteins in eukaryotic cells. 26S proteasome non-ATPase regulatory subunit 5 (PSMD5) is one of a number of chaperones that are involved in the assembly of the proteasome. The chaperones dissociate before 26S proteasome formation is complete [ ].TNF-alpha/NFkB inhibits 26S proteasome assembly via abnormal expression of PSMD5, establishing a link between inflammation and chronic neurodegenerativediseases with altered ubiquitin-proteasome system function [ ].
Short Name  PSMD5

0 Child Features

1 Gene Families

163 Genes

1 Ontology Annotations

0 Parent Features

14 Publications

USDA
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