Protein Domain : DDRGK domain containing protein IPR019153

Type  Family
Description  This is a family of proteins that contain a highly conserved DDRGK motif. In humans, DDRGK domain-containing protein 1 is a substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) [ ]. It is also involved in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator [].
Short Name  DDRGK_dom-contain

0 Child Features

1 Gene Families

112 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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