v5.1.0.3
Glycine data from LIS
Type | Family |
Description | This is a family of proteins that contain a highly conserved DDRGK motif. In humans, DDRGK domain-containing protein 1 is a substrate adapter for ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, which plays a key role in reticulophagy (also called ER-phagy) [ ]. It is also involved in cartilage development through SOX9, inhibiting the ubiquitin-mediated proteasomal degradation of this transcriptional regulator []. |
Short Name | DDRGK_dom-contain |