v5.1.0.3
Glycine data from LIS
Type | Family |
Description | GINS is a key component of eukaryotic replicative forks. It is part of the CMG (Cdc45-MCM-GINS) complex, the eukaryotic replicative helicase that unwinds double-stranded DNA at replication forks [ ]. Beside its role as a key component of the CMG complex, GINS mediates a interactions with many replication factors [, ].GINS is composed of four subunits: Sld5, Psf1, Psf2, and Psf3 [ ]. The four subunits are structurally related and are likely to derive from a single protein. They share a common fold made up of an α-helical A domain and a beta rich B domain. Sld5 and Psf1 possess the A domain at the N terminus and the B domain at the C terminus, whereas these two domains are swapped in Psf2 and Psf3 []. All subunits are essential for DNA replication.This family of proteins represents the Sld5 subunit. |
Short Name | GINS_Sld5 |