Protein Domain : GINS complex subunit Sld5 IPR008591

Type  Family
Description  GINS is a key component of eukaryotic replicative forks. It is part of the CMG (Cdc45-MCM-GINS) complex, the eukaryotic replicative helicase that unwinds double-stranded DNA at replication forks [ ]. Beside its role as a key component of the CMG complex, GINS mediates a interactions with many replication factors [, ].GINS is composed of four subunits: Sld5, Psf1, Psf2, and Psf3 [ ]. The four subunits are structurally related and are likely to derive from a single protein. They share a common fold made up of an α-helical A domain and a beta rich B domain. Sld5 and Psf1 possess the A domain at the N terminus and the B domain at the C terminus, whereas these two domains are swapped in Psf2 and Psf3 []. All subunits are essential for DNA replication.This family of proteins represents the Sld5 subunit.
Short Name  GINS_Sld5

0 Child Features

0 Gene Families

109 Genes

1 Ontology Annotations

0 Parent Features

13 Publications

USDA
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