v5.1.0.3
Glycine data from LIS
Type | Homologous_superfamily |
Description | This domain is found in a widespread superfamily known as MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) [ ]. Included in this superfamily are:5-lipoxygenase activating protein (gene FLAP), which seems to be required for the activation of 5-lipoxygenase.Leukotriene C4 synthase ( ), which catalyses the production of LTC4 from LTA4. Microsomal glutathione S-transferase II ( ) (GST-II), which also produces LTC4 from LTA4. Prostaglandin E synthase, which catalyses the synthesis of PGE2 from PGH2 (produced by cyclooxygenase from arachidonic acid). The structure of this domain consists of four transmembrane helices [ ]. |
Short Name | MAPEG-like_dom_sf |