Protein Domain : Nuclear cap-binding protein subunit 2 IPR027157

Type  Family
Description  Nuclear cap-binding protein subunit 2 (NCBP2, also known as CBC2 and CBP20) forms the CBC complex with the nuclear cap-binding protein subunit 1 ( ). The CBC complex binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in maturation, export and degradation of nuclear mRNAs [ , , , ]. In humans, the CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus and plays a central role in nonsense-mediated mRNA decay (NMD) []. During cell proliferation, the CBC complex is involved in microRNAs (miRNAs) biogenesis via its interaction with SRRT/ARS2, thereby being required for miRNA-mediated RNA interference [].
Short Name  NCBP2

0 Child Features

1 Gene Families

111 Genes

3 Ontology Annotations

0 Parent Features

14 Publications

USDA
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