Protein Domain : Imidazole glycerol phosphate synthase HisHF IPR014640

Type  Family
Description  Members of this group are eukaryotic bifunctional enzymes with glutamine amidotransferase ( ) and cyclase activities ( ) that catalyse the fifth and sixth steps of the histidine biosynthetic pathway. In eubacteria, these steps are catalysed by a complex formed by two subunits, namely the glutamine amidotransferase HisH ( ) and the cyclase HisF which are encoded in the same operon [ ].The catalytic activity has been assessed for many members, mainly by complementation assays. The Saccharomyces cerevisiae (Baker's yeast) member is able to suppress His auxotrophy of corresponding Escherichia coli hisH and hisF mutants [ ]. In plants, hisHF cDNA from Emericella nidulans (Aspergillus nidulans) and Arabidopsis thaliana (Mouse-ear cress) complemented a S. cerevisiae his7Deltastrain [ , ]. In addition, A. nidulans cDNA complemented E. coli hisHand hisFmutant strains [ ].
Short Name  IGPS_HisHF
Paste the following link
Lists
This ProteinDomain isn't in any lists. Upload a list.

0 Child Features

1 Gene Families

Trail: ProteinDomain

84 Genes

Trail: ProteinDomain

4 Ontology Annotations

Trail: ProteinDomain

0 Parent Features

13 Publications

Trail: ProteinDomain
USDA
InterMine logo
The Legume Information System (LIS) is a research project of the USDA-ARS:Corn Insects and Crop Genetics Research in Ames, IA.
LegumeMine || ArachisMine | CicerMine | GlycineMine | LensMine | LupinusMine | PhaseolusMine | VignaMine | MedicagoMine
InterMine © 2002 - 2022 Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, United Kingdom