v5.1.0.3
Glycine data from LIS
Type | Family |
Description | Archaeal and eukaryotic translation elongation factor 2 contain a unique posttranslationally modified histidine residue called diphthamide, the target of the diphtheria toxin. Diphtheria toxin inhibits eukaryotic protein synthesis by ADP-ribosylating diphthamide in EF2 [ ].Members of this family include 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1/2 (also known as Diphtheria toxin resistance protein 1/2, DPH 1/2), which are involved in the first step of diphthamide synthesis [ , ]. Archaeal DPHs are more similar to eukaryotic DPH1 than to DPH2 []. |
Short Name | DPH1/DPH2 |