Ontology Term : Pfam:PF06148 COG (conserved oligomeric Golgi) complex component, COG2 EMBL-EBI

Description  The COG complex comprises eight proteins COG1-8. The COG complex plays critical roles in Golgi structure and function [1]. The proposed function of the complex is to mediate the initial physical contact between transport vesicles and their membrane targets. A comparable role in tethering vesicles has been suggested for at least six additional large multisubunit complexes, including the exocyst, a complex that mediates trafficking to the plasma membrane. COG2 structure reveals a six-helix bundle with few conserved surface features but a general resemblance to recently determined crystal structures of four different exocyst subunits. These bundles inCOG2 may act as platforms for interaction with other trafficing proteins including SNAREs (soluble N-ethylmaleimide factor attachment protein receptors) and Rabs [2].
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