GO Term : GO:0002542 Factor XII activation Gene Ontology

Description  Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade.
Namespace  biological_process
Obsolete  false

0 Data Sets

1 Ontology

Trail: GOTerm

0 Ontology Annotations

64 Parents

Trail: GOTerm

99 Relations

Trail: GOTerm

1 Synonyms

Trail: GOTerm
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