Protein Domain : DNA (cytosine-5)-methyltransferase 1, replication foci domain IPR022702

Type  Domain
Description  This domain is part of a cytosine specific DNA methyltransferase enzyme (DNMT). It functions non-catalytically to target the protein towards replication foci. This allows the DNMT1 protein to methylate the correct residues. This domain targets DMAP1 and HDAC2 to the replication foci during the S phase of mitosis. They are thought to have some importance in conversion of critical histone lysine moieties [ ].A structure exists for the human cytosine specific DNA methyltransferase replication foci domain [ ].
Short Name  Cytosine_MeTrfase1_RFD
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0 Child Features

2 Gene Families

Trail: ProteinDomain

307 Genes

Trail: ProteinDomain

0 Ontology Annotations

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14 Publications

Trail: ProteinDomain
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