v5.1.0.3
Glycine data from LIS
Type | Homologous_superfamily |
Description | This superfamily represents a structural domain consisting of a TIM beta/α-barrel. These domains are found in several phospholipase C (PLC) like phosphodiesterases, including:Mammalian phospholipase C isozyme D1 [ ].Bacterial phosphatidylinositol-specific phospholipase C [ ].Glycerophosphodiester phosphodiesterases, such as GlpQ from Escherichia coli and UgpQ from Agrobacterium tumefaciens [ ].Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyse phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. PLC enzymes often play central roles in various signalling cascades [ ]. |
Short Name | PLC-like_Pdiesterase_TIM-brl |