Protein Domain : PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily IPR017946

Type  Homologous_superfamily
Description  This superfamily represents a structural domain consisting of a TIM beta/α-barrel. These domains are found in several phospholipase C (PLC) like phosphodiesterases, including:Mammalian phospholipase C isozyme D1 [ ].Bacterial phosphatidylinositol-specific phospholipase C [ ].Glycerophosphodiester phosphodiesterases, such as GlpQ from Escherichia coli and UgpQ from Agrobacterium tumefaciens [ ].Phospholipase C (PLC) isozymes are directly activated by heterotrimeric G proteins and Ras-like GTPases to hydrolyse phosphatidylinositol 4,5-bisphosphate into the second messengers diacylglycerol and inositol 1,4,5-trisphosphate. PLC enzymes often play central roles in various signalling cascades [ ].
Short Name  PLC-like_Pdiesterase_TIM-brl

0 Child Features

4 Gene Families

1000 Genes

2 Ontology Annotations

0 Parent Features

14 Publications

USDA
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