Protein Domain : C-5 cytosine methyltransferase IPR001525

Type  Family
Description  C-5 cytosine-specific DNA methylases ( ) (C5 Mtase) are enzymes that specifically methylate the C-5 carbon of cytosines in DNA to produce C5-methylcytosine [ , , ]. In mammalian cells, cytosine-specific methyltransferases methylate certain CpG sequences, which are believed to modulate gene expression and cell differentiation. In bacteria, these enzymes are a component of restriction-modification systems and serve as valuable tools for the manipulation of DNA [, ]. The structure of HhaI methyltransferase (M.HhaI) has been resolved to 2.5 A []: the molecule folds into 2 domains - a larger catalytic domain containing catalytic and cofactor binding sites, and a smaller DNA recognition domain.This entry also includes tRNA (cytosine(38)-C(5))-methyltransferase ( ), also known as DNMT2 (DNA (cytosine-5)-methyltransferase-like protein 2), that specifically methylates cytosine 38 in the anticodon loop of tRNA (Asp) [ ].
Short Name  C5_MeTfrase

1 Child Features

9 Gene Families

698 Genes

1 Ontology Annotations

0 Parent Features

14 Publications

USDA
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