Protein Domain : Cathepsin propeptide inhibitor domain (I29) IPR013201

Type  Domain
Description  This entry represents a peptidase inhibitor domain, which belongs to MEROPS peptidase inhibitor family I29. The domain is also found at the N terminus of a variety of peptidase precursors that belong to MEROPS peptidase subfamily C1A; these include cathepsin L, papain, and procaricain ( ) [ ]. It forms an α-helical domain that runs through the substrate-binding site, preventing access. Removal of this region by proteolytic cleavage results in activation of the enzyme. This domain is also found, in one or more copies, in a variety of cysteine peptidase inhibitors such as salarin [].
Short Name  Prot_inhib_I29

0 Child Features

1 Gene Families

1000 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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