Protein Domain : WHEP-TRS domain IPR000738

Type  Domain
Description  A conserved domain of 46 amino acids, called WHEP-TRS has been shown [ ] to exist in a number of higher eukaryote aminoacyl-transfer RNA synthetases. This domain is present one to six times in the several enzymes. There are three copies in mammalian multifunctional aminoacyl-tRNA synthetase in a region that separates the N-terminal glutamyl-tRNA synthetase domain from the C-terminal prolyl-tRNA synthetase domain, and six copies in the intercatalytic region of the Drosophila enzyme. The domain is found at the N-terminal extremity of the mammalian tryptophanyl-tRNA synthetase and histidyl-tRNA synthetase, and the mammalian, insect, nematode and plant glycyl-tRNA synthetases []. The structure of a human WHEP-TRS domain has been solved and consists of two helices arranged in a helix-turn-helix []. The WHEP-TRS domain may play a role in the association of tRNA-synthetases into multienzyme complexes [].
Short Name  WHEP-TRS_dom

0 Child Features

0 Gene Families

254 Genes

3 Ontology Annotations

0 Parent Features

13 Publications

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