Protein Domain : Glutamyl-tRNA reductase, conserved site IPR018214

Type  Conserved_site
Description  Delta-aminolevulinic acid (ALA) is the obligatory precursor for the synthesis of all tetrapyrroles including porphyrin derivatives such as chlorophyll and heme. ALA can be synthesized via two different pathways: the Shemin (or C4) pathway which involves the single step condensation of succinyl-CoA and glycine and which is catalyzed by ALA synthase and via the C5 pathway from the five-carbon skeleton of glutamate. The C5 pathway operates in the chloroplast of plants and algae, in cyanobacteria, in some eubacteria and in archaebacteria [ ].The initial step in the C5 pathway is carried out by glutamyl-tRNA reductase (GluTR) which catalyzes the NADP-dependent conversion of glutamate- tRNA(Glu) to glutamate-1-semialdehyde (GSA) with the concomitant release of tRNA(Glu) which can then be recharged with glutamate by glutamyl-tRNA synthetase [ ].This entry represents the conserved site of glutamyl-tRNA reductase. This region seems important for the activity of the enzyme.
Short Name  GluRdtase_CS

0 Child Features

0 Gene Families

326 Genes

1 Ontology Annotations

0 Parent Features

13 Publications

USDA
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