Protein Domain : Replication termination factor 2, RING-finger IPR027799

Type  Domain
Description  It is vital for effective cell-replication that replication is not stalled at any point by, for instance, damaged bases. Replication termination factor 2 (Rtf2) stabilises the replication fork stalled at the site-specific replication barrier RTS1 by preventing replication restart until completion of DNA synthesis by a converging replication fork initiated at a flanking origin. The RTS1 element terminates replication forks that are moving in the cen2-distal direction while allowing forks moving in the cen2-proximal direction to pass through the region. Rtf2 contains a C2HC2 motif related to the C3HC4 RING-finger motif, and would appear to fold up, creating a RING finger-like structure but forming only one functional Zn2+ ion-binding site [ ].
Short Name  Rtf2_RING-finger

0 Child Features

2 Gene Families

216 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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