Protein Domain : Adaptor protein complex AP-2, alpha subunit IPR017104

Type  Family
Description  Adaptor protein complex AP-2 has a role in clathrin-mediated endocytosis and intracellular transport [ ]. AP-2 links clathrin to membrane lipids and transmembrane cargoes at the vesicle budding site []. It consists of two large subunits termed adaptins (alpha and beta subunits), a medium-sized one (mu), and a small one (sigma). It is thought to act in cargo selection by interaction with selection motifs encoded in the cytoplasmic tails of cargo molecules. The N-terminal domains of the adaptins, together with the mu and sigma subunits, constitute the 'head' of the adaptor, which interacts with plasma membrane lipids and cargoes. AP-2 plays a role in the recycling of synaptic vesicle membranes from the presynaptic surface [].This family represents the alpha subunit of adaptor protein complex AP-2.
Short Name  AP2_complex_asu

0 Child Features

1 Gene Families

105 Genes

4 Ontology Annotations

0 Parent Features

14 Publications

USDA
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