v5.1.0.3
Glycine data from LIS
Type | Family |
Description | Adaptor protein complex AP-2 has a role in clathrin-mediated endocytosis and intracellular transport [ ]. AP-2 links clathrin to membrane lipids and transmembrane cargoes at the vesicle budding site []. It consists of two large subunits termed adaptins (alpha and beta subunits), a medium-sized one (mu), and a small one (sigma). It is thought to act in cargo selection by interaction with selection motifs encoded in the cytoplasmic tails of cargo molecules. The N-terminal domains of the adaptins, together with the mu and sigma subunits, constitute the 'head' of the adaptor, which interacts with plasma membrane lipids and cargoes. AP-2 plays a role in the recycling of synaptic vesicle membranes from the presynaptic surface [].This family represents the alpha subunit of adaptor protein complex AP-2. |
Short Name | AP2_complex_asu |