v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | Glucose-6-phosphate dehydrogenase ( ) (G6PDH) is a ubiquitous protein, present in bacteria and all eukaryotic cell types [ ]. The enzyme catalyses the the first step in the pentose pathway, i.e. the conversion of glucose-6-phosphate to gluconolactone 6-phosphate in the presence of NADP, producing NADPH. The ubiquitous expression of the enzyme gives it a major role in the production of NADPH for the many NADPH-mediated reductive processes in all cells, and is critical for NADPH homeostasis and redox regulation []. Deficiency of G6PDH is a common genetic abnormality affecting millions of people worldwide. Many sequence variants, most caused by single point mutations, are known, exhibiting a wide variety of phenotypes with the distinctive one being chronic and drug- or food-induced hemolytic anemia, attributed to the inability to produce NADPH and withstand harmful oxidants in erythrocyte cells [, ].This entry represents the NAD-binding domain of glucose-6-phosphate dehydrogenase. |
Short Name | G6P_DH_NAD-bd |