Protein Domain : 2-oxoisovalerate dehydrogenase, E1 alpha subunit, N-terminal domain IPR022593

Type  Domain
Description  This domain is part of the N-terminal tail and β-sheet region of the bacterial 2-oxoisovalerate dehydrogenase E1 alpha subunit [ , ]. It is found N-terminal to the dehydrogenase component . There are two conserved sequence motifs: VPEP and RPG. The E1 subunit is a thiamin diphosphate (ThDP)-dependent 2-oxo acid dehydrogenase (decarboxylase) belonging to the pyruvate dehydrogenase multienzyme complex. This is the enzyme complex responsible for metabolism of pyruvate, 2-oxoglutarate, branched chain 2-oxo acids and acetoin. The E1 component is a heterotetramer of alpha2beta2. The homodimerised beta subunits are flanked by two alpha subunits in a 'vise' structure.
Short Name  Oxoisoval_DH_suAlpha_N_dom

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