Protein Domain : Mechanosensitive ion channel MscS, transmembrane-2 IPR011014

Type  Homologous_superfamily
Description  MscS is a mechanosensitive channel present in the membrane of bacteria, archaea and eukarya that responds both to stretching of the cell membrane and to membrane depolarisation [ , , , ]. MscS folds as a homo-heptamer with a cylindrical shape, and can be divided into transmembrane and extramembrane regions: an N-terminal periplasmic region, a transmembrane region, and a C-terminal cytoplasmic region. The MscS family of channels shows diversity in size and sequence between its members; most of the diversity occurs in the size of the transmembrane region, which ranges from three to eleven transmembrane helices, although the three C-terminal helices are conserved. This domain superfamily covers the core transmembrane region, which consists of three transmembrane helices per subunit in an oligomeric fold.
Short Name  MscS_channel_TM-2

0 Child Features

0 Gene Families

104 Genes

1 Ontology Annotations

0 Parent Features

13 Publications

USDA
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