Protein Domain : Glutamate--cysteine ligase, GCS2 IPR006336

Type  Family
Description  Also known as gamma-glutamylcysteine synthetase and gamma-ECS ( ). This enzyme catalyses the first and rate limiting step in de novo glutathione biosynthesis. Members of this family are found in archaea, bacteria and plants. May and Leaver [ ] discuss the possible evolutionary origins of glutamate-cysteine ligase enzymes in different organisms and suggest that it evolved independently in different eukaryotes, from an ancestral bacterial enzyme. They also state that Arabidopsis thaliana (Mouse-ear cress) gamma-glutamylcysteine synthetase is structurally unrelated to mammalian, yeast and Escherichia coli homologues. In plants, there are separate cytosolic and chloroplast forms of the enzyme.
Short Name  GCS2

3 Child Features

2 Gene Families

244 Genes

2 Ontology Annotations

0 Parent Features

14 Publications

USDA
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