LIS - Legume Information System
Information about legume traits for crop improvement
GlycineMine
v5.1.0.3
Glycine data from LIS
v5.1.0.3
Glycine data from LIS
| Type | Conserved_site |
| Description | Synonym(s): Inosine-5'-monophosphate dehydrogenase, Inosinic acid dehydrogenase; Synonym(s): Guanosine 5'-monophosphate oxidoreductase This entry contains two related enzymes: IMP dehydrogenase and GMP reductase. These enzymes adopt a TIM barrel structure.IMP dehydrogenase ( ) (IMPDH) catalyses the rate-limiting reaction of de novoGTP biosynthesis, the NAD-dependent reduction of IMP into XMP [ ].Inosine 5-phosphate + NAD++ H 2O = xanthosine 5-phosphate + NADH IMP dehydrogenase is associated with cell proliferation and is a possible target for cancer chemotherapy. Mammalian and bacterial IMPDHs are tetramers of identical chains. There are two IMP dehydrogenase isozymes in humans []. IMP dehydrogenase nearly always contains a long insertion that has two CBS domains within it.GMP reductase ( ) catalyses the irreversible and NADPH-dependent reductive deamination of GMP into IMP [ ].NADPH + guanosine 5-phosphate = NADP++ inosine 5-phosphate + NH 3It converts nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and maintains intracellular balance of A and G nucleotides. |
| Short Name | IMP_DH/GMP_Rdtase_CS |
