Protein Domain : TBP domain superfamily IPR012295

Type  Homologous_superfamily
Description  The TATA-box binding protein (TBP) is required for the initiation of transcription by RNA polymerases I, II and III, from promoters with or without a TATA box [ , ]. The core of TBP (~180 residues) is highly conserved and contains two 77-amino acid repeats that produce a saddle-shaped structure that straddles the DNA; this region binds to the TATA box, and interacts with transcription factors and regulatory proteins []. TBP shares structural similarity with the C-terminal of beta(2)-adaptin, which is one of four subunits that comprise the clathrin adaptor. This structure can also be found in the N terminus of RNase H3. The N terminus of RNase H3 is suggested to be a substrate binding domain [ ].
Short Name  TBP_dom_sf

0 Child Features

2 Gene Families

652 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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