v5.1.0.3
Glycine data from LIS
Type | Domain |
Description | This is part of a possible metal-binding domain in endoribonuclease RNase L inhibitor. It is found at the N-terminal end of RNase L inhibitor proteins, adjacent to the 4Fe-4S binding domain, . Also often found adjacent to in uncharacterised proteins. The RNase L system plays a major role in the anti-viral and anti-proliferative activities of interferons [ ]. It is a component of the multifactor complex (MFC) involved in translation initiation and it is required for the processing and nuclear export of the 60S and 40S ribosomal subunits, playing a role in ribosome biogenesis [, . Inhibitory activity requires concentration-dependent association of RLI with RNase L [ ]. |
Short Name | RNaseL-inhib-like_metal-bd_dom |