Protein Domain : ALIX V-shaped domain IPR025304

Type  Domain
Description  The binding of the LYPxL motif of late HIV p6Gag and EIAV p9Gag to this domain is necessary for viral budding. In ALIX, a component of the ESCRT pathway, this domain is central between an N-terminal Bro1 domain ( ) and a C-terminal proline-rich domain. The ALIX central domain is formed by two three-helix bundles disposed in a V shape [ , ]. Retroviruses thus used this domain to hijack the ESCRT system of the cell [].
Short Name  ALIX_V_dom
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0 Child Features

1 Gene Families

Trail: ProteinDomain

119 Genes

Trail: ProteinDomain

1 Ontology Annotations

Trail: ProteinDomain

0 Parent Features

14 Publications

Trail: ProteinDomain
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