Protein Domain : BRO1 domain IPR004328

Type  Domain
Description  The BRO1 domain is a protein domain of ~390 residues in length. It occurs in a number of eukaryotic proteins, such as yeast BRO1 and human PDCD6IP/Alix, which are involved in protein targeting to the vacuole or lysosome. The BRO1 domain of fungal and mammalian proteins binds with multivesicular body components (ESCRT-III proteins) such as yeast Snf7 and mammalian CHMP4b, and can function to target BRO1 domain-containing proteins to endosomes [ , , ].The BRO1 domain has a boomerang shape composed of 14 α-helices and 3 β-sheets. It contains a TPR-like substructure in the central part [ ]. The C terminus is less conserved.
Short Name  BRO1_dom

1 Child Features

6 Gene Families

587 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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