Protein Domain : Transcription elongation factor Eaf, N-terminal IPR019194

Type  Domain
Description  This entry represents the N-terminal domain of ELL-associated factor (Eaf) proteins, which act as transcriptional transactivators of ELL and ELL2 RNA Polymerase II (Pol II) transcriptional elongation factors [ , , , ]. Eaf proteins form a stable heterodimer complex with ELL proteins to facilitate the binding of RNA polymerase II to activate transcription elongation. ELL and EAF1 are components of Cajal bodies, which have a role in leukemogenesis []. EAF1 also has the capacity to interact with ELL1 and ELL2. The N terminus of approx 120 of EAF1 has a region of high serine, aspartic acid, and glutamic acid residues [, ].
Short Name  Tscrpt_elong_fac_Eaf_N

0 Child Features

1 Gene Families

113 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

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