Protein Domain : DNA-directed RNA polymerase, subunit 2, hybrid-binding domain IPR007120

Type  Domain
Description  RNA polymerases ( ) catalyse the DNA dependent polymerisation of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (notincluding mitochondrial and chloroplast polymerases). This domain represents the hybrid-binding domain and the wall domain []. Thehybrid-binding domain binds the nascent RNA strand/template DNA strand in the Pol II transcription elongation complex. This domain contains the important structuralmotifs, switch 3 and the flap loop and binds an active site metal ion [ ]. This domain is also involved in binding to Rpb1 and Rpb3[ ]. Many of the bacterial members contain large insertionswithin this domain, which are known as dispensable region 2 (DRII).
Short Name  DNA-dir_RNAP_su2_dom

0 Child Features

0 Gene Families

662 Genes

3 Ontology Annotations

0 Parent Features

13 Publications

USDA
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