LIS - Legume Information System
Information about legume traits for crop improvement
GlycineMine
v5.1.0.3
Glycine data from LIS
v5.1.0.3
Glycine data from LIS
| Type | Domain |
| Description | The Josephin domain is an eukaryotic protein module of about 180 residues, which occurs in stand-alone form in Josephin-like proteins, and as an amino-terminal domain associated with two or three copies of the ubiquitin- interacting motif (UIM) in ataxin 3-like proteins. Josephin domain-containing proteins function as de-ubiquitination enzymes []. Although it has originally been proposed that the Josephin domain could be an all-alpha helical domain distantly related to ENTH and VHS domains involved in membrane trafficking and regulatory adaptor function [], it is now believed that it is a mainly alpha helical cysteine-protease domain predicted to be active against ubiquitin chains or related substrates [, ].The Josephin domain contains two conserved histidines and one cysteine that is required for the ubiquitin protease activity [ , ] and two ubiquitin-binding sites [].Some proteins known to contain a Josephin domain are:Animal Machado-Joseph disease protein 1 (Ataxin 3). It interacts with key regulators (CBP, p300 and PCAF) of transcription and repressestranscription.Plant Machado-Joseph disease-like protein (MJD1a-like) (Ataxin 3 homologue).Mammalian Josephin 1 and 2.Drosophila melanogaster Josephin-like protein.Arabidopsis thaliana Josephin-like protein. |
| Short Name | Josephin |
