Protein Domain : FAM175 family IPR023238

Type  Family
Description  Members of protein family FAM175 include the BRCA1-A complex subunit Abraxas 1 [ , ], BRISC complex subunit Abraxas 2 or Abro1 (Abraxas brother protein 1) [, ], and uncharacterised plant proteins.It is thought that BRCA1-A complex subunit Abraxas acts as a central scaffold protein responsible for assembling the various components of the BRCA1-A complex, and mediates recruitment of BRCA1 [ , ]. Similarly, Abro1 probably acts as a scaffold facilitating assembly of the various components of BRISC [] - the protein does not interact with BRCA1, but binds polyubiquitin []. The primary sequences of these proteins contain an MPN-like domain [].
Short Name  FAM175

3 Child Features

0 Gene Families

88 Genes

0 Ontology Annotations

0 Parent Features

12 Publications

USDA
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