Protein Domain : AWS domain IPR006560

Type  Domain
Description  This domain, Associated With SET (AWS), whose specific function is still unknown, is found in a group of histone-lysine N-methyltransferases and similar eukaryotic proteins, including Histone-lysine N-methyltransferase, H3 lysine-36 specific from humans (H3-K36-HMTase or Nsd1). Nsd1 is a transcriptional intermediary factor capable of both negatively or positively influencing transcription, depending on the cellular context. Mutations in this protein are associated with several human disorders such as Sotos syndrome [ , ]. This cysteine-rich domain is often found in association with the SET domain ().
Short Name  AWS_dom

0 Child Features

5 Gene Families

357 Genes

2 Ontology Annotations

0 Parent Features

14 Publications

USDA
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