Protein Domain : Glycoside hydrolase, family 27 IPR002241

Type  Family
Description  O-Glycosyl hydrolases ( ) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [ , ]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.Glycoside hydrolase family 27 comprises enzymes with several known activities; alpha-galactosidase ( ); alpha-N-acetylgalactosaminidase ( ); isomalto-dextranase ( ). Alpha-galactosidase (melibiase) catalyses the hydrolysis of melibiose into galactose and glucose []. In man, deficiency in the enzyme results inFabry's disease (X-linked sphingolipidosis). Alpha-N-acetylgalactosaminidase catalyses the hydrolysis of terminal non-reducing N-acetyl-D-galactosamineresidues in N-acetyl-alpha-D-galactosaminides [ ]. Two conserved Asp residues may be involved in the catalytic mechanism in these enzymes. Deficiency in this enzyme results in Schindler and Kanzaki diseases.
Short Name  Glyco_hydro_27

1 Child Features

0 Gene Families

688 Genes

2 Ontology Annotations

0 Parent Features

13 Publications

USDA
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