Protein Domain : Surfeit locus 6 IPR007019

Type  Family
Description  This entry represents the surfeit locus protein SURF6 from mammals and its homologues from plants and fungi. In mammals, SURF6 is a component of the nucleolar matrix and has a strong binding capacity for nucleic acids [ ]. SURF6 is always found in the nucleolus regardless of the phase of the cell cycle suggesting that it is a structural protein constitutively present in nucleolar substructures. A role in rRNA processing has been proposed for this protein. Saccharomyces cerevisiae member of the SURF-6 family, named Rrp14 (ribosomal RNA-processing protein 14), interacts with proteins involved in ribosomal biogenesis and cell polarity [ ]. It is required for the synthesis of both 40S and 60S ribosomal subunits and may also play some direct role in correct positioning of the mitotic spindle during mitosis [, ].
Short Name  SURF6

0 Child Features

2 Gene Families

104 Genes

0 Ontology Annotations

0 Parent Features

14 Publications

USDA
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